Prinzmetal's variant angina

Common Name(s)

Prinzmetal's variant angina

Prinzmetal’s variant angina is severe chest pain (angina) that occurs while a person is resting or sleeping. This condition is caused by a spasm in the coronary artery (which supplies blood to the heart muscle). The spasm temporarily narrows the artery cutting off the heart’s blood supply. About two-thirds of individuals with Prinzmetal’s angina also have plaque buildup (atherosclerosis) in their coronary arteries, but atherosclerosis is not thought to be the cause. Only about 2% of cases of angina are Prinzmetal but it happens more often in younger adults than other angina types.

Symptoms of an attack include nausea, fatigue, shortness of breath, sweating, and dizziness. Usually, there is also some pain in the chest, arms, neck, jaw, shoulders, or back. The pain is described as a pressure or squeezing feeling. Others describe it as though a large weight has been placed on their chest, or like indigestion. Individuals of Japanese descent seem to have a higher risk for the disease than others. The spasms may be brought on by cold weather, stress, certain medications, smoking or cocaine use. Spasms tend to come in cycles and then may disappear for a while only to return again.

Diagnosis can be challenging because it is often only diagnosed after other heart diseases have been ruled out. An electrocardiogram (EKG) can make a positive diagnosis, but only if the person is being monitored when the attack happens. Medication to control the spasms is the most common treatment. The condition is chronic (lifelong), but with treatment the outlook for a healthy life is good. Research is ongoing, so talk to your doctor about the most current treatment options. Support groups are also a good source of information and can help connect you with others affected by Prinzmetal’s variant angina.

Source: Advocacy organizations associated with the condition.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Prinzmetal's variant angina" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Prinzmetal's variant angina" returned 16 free, full-text research articles on human participants. First 3 results:

Recurrent myocardial infarction secondary to Prinzmetal's variant angina.
 

Author(s): Dale Murdoch, Priyanka Dhillon, Selvanayagam Niranjan

Journal: Singapore Med J. 2015 May;56(5):e74-7.

 

Prinzmetal's variant angina describes chest pain secondary to reversible coronary artery vasospasm in the context of both diseased and non-diseased coronary arteries. Symptoms typically occur when the patient is at rest and are associated with transient ST-segment elevation. Acute ...

Last Updated: 31 Dec 1969

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[Prinzmetal's variant angina. Rare disease caused by coronary artery spasms].
 

Author(s): Carl Granath, Martin Roll

Journal: Lakartidningen. 2014 09;111(37):1514-6.

 

Last Updated: 31 Dec 1969

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Prinzmetal's variant angina associated with severe heart rhythm disturbances and syncope: a therapeutic dilemma.
 

Author(s): Anna Ledakowicz-Polak, Paweł Ptaszyński, Łukasz Polak, Marzenna Zielińska

Journal: Cardiol J. 2009 ;16(3):269-72.

 

Prinzmetal's angina is a distinct syndrome characterized by episodes of chest pain and transient ST-segment elevation caused by coronary vasospasm. This variant form of angina is sometimes associated with complete atrioventricular block and ventricular arrhythmias. We report here ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Prinzmetal's variant angina" returned 2 free, full-text review articles on human participants. First 3 results:

Prinzmetal's variant angina.
 

Author(s): J T S Soares-Costa, Teresa J J B Soares-Costa

Journal: Rev Port Cardiol. 2004 Oct;23(10):1337-56.

 

Last Updated: 31 Dec 1969

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Prinzmetal's variant angina.
 

Author(s): S Mayer, L D Hillis

Journal: Clin Cardiol. 1998 Apr;21(4):243-6.

 

Although the prevalence of variant angina pectoris is unknown, it appears to be substantially less common than typical, exertional angina and unstable angina at rest. The patient with variant angina typically complains of a pressure-like, squeezing retrosternal chest discomfort of ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

ANti-Oxidant in Variant Angina (ANOVA) Trial
 

Status: Recruiting

Condition Summary: Variant Angina

 

Last Updated: 20 Jul 2017

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Multidetector Coronary CT In Vasospastic Angina
 

Status: Recruiting

Condition Summary: Vasospastic Angina

 

Last Updated: 30 Jan 2018

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The Effect of Sarpogrelate and High Dose Statin on the Reduction of Coronary Spasm
 

Status: Recruiting

Condition Summary: Variant Angina

 

Last Updated: 7 Feb 2018

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