Progressive multifocal leukoencephalopathy

Common Name(s)

Progressive multifocal leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML) is a neurological disorder that damages the myelin that covers and protects nerves in the white matter of the brain. It is caused by the JC virus (JCV). By age 10, most people have been infected with this virus, but it rarely causes symptoms unless the immune system becomes severely weakened.  The disease occurs, rarely, in organ transplant patients; people undergoing chronic corticosteroid or immunosuppressive therapy; and individuals with cancer, such as HodgkinÕs disease, lymphoma, and sarcoidosis.  PML is most common among individuals with acquired immune deficiency syndrome (AIDS).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive multifocal leukoencephalopathy" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Progressive multifocal leukoencephalopathy" returned 215 free, full-text research articles on human participants. First 3 results:

Progressive multifocal leukoencephalopathy associated with thymoma with immunodeficiency: a case report and literature review.
 

Author(s): Tatsuya Ueno, Nobuyuki Sato, Tomoya Kon, Rie Haga, Jin-Ichi Nunomura, Kazuo Nakamichi, Masayuki Saijo, Masahiko Tomiyama

Journal:

 

The development of progressive multifocal leukoencephalopathy (PML) is associated with severe cellular immunosuppression. Good's syndrome (GS) is a rare immunodeficiency syndrome related to thymoma, with the development of humoral as well as cellular immunosuppression; however, there ...

Last Updated: 31 Dec 1969

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Prevention and therapy of JC polyomavirus-mediated progressive multifocal leukoencephalopathy - a realistic possibility?
 

Author(s): Ivan Jelcic, Benoit Combaluzier, Ilijas Jelcic, Mireia Sospedra, Jan Grimm, Roland Martin

Journal:

 

Progressive multifocal leukoencephalopathy (PML) is a serious opportunistic infection of the brain caused by the JC polyomavirus (JCPyV). PML occurs when immune control of persistent infection with JCPyV fails, the virus mutates and changes its cellular tropism, enters the brain and ...

Last Updated: 31 Dec 1969

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Posterior fossa progressive multifocal leukoencephalopathy: first presentation of an unknown autoimmune disease.
 

Author(s): Paulette Scholten, Peter Kralt, Bram Jacobs

Journal:

 

We present a case of a 57-year-old man who presented with progressive cerebellar dysarthria and cerebellar ataxia. Additional investigations confirmed the diagnosis of progressive multifocal leukoencephalopathy (PML) in the posterior fossa. This is a demyelinating disease of the central ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Progressive multifocal leukoencephalopathy" returned 42 free, full-text review articles on human participants. First 3 results:

Progressive multifocal leukoencephalopathy.
 

Author(s): Karl Bjørnar Alstadhaug, Kjell-Morten Myhr, Christine Hanssen Rinaldo

Journal:

 

Progressive multifocal leukoencephalopathy is a rare, opportunistic infection of the central nervous system caused by the John Cunningham virus (JCV). There is no effective antiviral treatment available, and restoring immunocompetence is essential for survival. If this occurs too ...

Last Updated: 31 Dec 1969

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Progressive Multifocal Leukoencephalopathy and Monoclonal Antibodies: A Review.
 

Author(s): Chandrashekar Bohra, Lubomir Sokol, Samir Dalia

Journal: Cancer Control. ;24(4):1073274817729901.

 

Progressive multifocal leukoencephalopathy (PML) is a viral infection predominantly seen in patients with HIV infection. However, with the increased use of monoclonal antibodies (MAB) for various lymphoproliferative disorders, we are now seeing this infection in non-HIV patients on ...

Last Updated: 31 Dec 1969

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Progressive Multifocal Leukoencephalopathy in Primary Immune Deficiencies: Stat1 Gain of Function and Review of the Literature.
 

Author(s): Christa S Zerbe, Beatriz E Marciano, Rohit K Katial, Carah B Santos, Nick Adamo, Amy P Hsu, Mary E Hanks, Dirk N Darnell, Martha M Quezado, Cathleen Frein, Lisa A Barnhart, Victoria L Anderson, Gulbu Uzel, Alexandra F Freeman, Andrea Lisco, Avindra Nath, Eugene O Major, Elizabeth P Sampaio, Steven M Holland

Journal: Clin. Infect. Dis.. 2016 Apr;62(8):986-94.

 

Progressive multifocal leukoencephalopathy (PML) is a rare, severe, otherwise fatal viral infection of the white matter of the brain caused by the polyomavirus JC virus, which typically occurs only in immunocompromised patients. One patient with dominant gain-of-function (GOF) mutation ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)
 

Status: Recruiting

Condition Summary: Progressive Multifocal Leukoencephalopathy

 

Last Updated: 8 Aug 2018

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Difference in Efficacy of Natalizumab Versus Fingolimod for the Treatment of Multiple Sclerosis
 

Status: Recruiting

Condition Summary: Multiple Sclerosis

 

Last Updated: 21 Feb 2017

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