Protein C Deficiency

Common Name(s)

Protein C Deficiency

Protein C deficiency is a disorder of blood clotting. People with this condition have an increased risk of developing abnormal blood clots. Protein C is found in the bloodstream and blocks the activity of (inactivates) certain proteins that promote blood clotting. Those with protein C deficiency do not have enough functional protein C to inactivate clotting proteins, which results in an increased risk of developing abnormal blood clots. Other factors can raise the risk of abnormal blood clots in people with mild protein C deficiency. These factors include increasing age, surgery, immobility, or pregnancy. The combination of protein C deficiency and other inherited disorders of blood clotting can also influence the risk. However, most people with mild protein C deficiency never develop abnormal blood clots. Protein C deficiency can be inherited or acquired. Inherited forms are caused by mutations in the PROC gene and inherited in an autosomal dominant fashion.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Protein C Deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Protein C Deficiency" returned 144 free, full-text research articles on human participants. First 3 results:

Acute Anorectal Thrombophlebitis Caused by a Protein C Deficiency.
 

Author(s): Yuji Eso, Satoshi Yoshiji, Yuto Nakakubo, Minoru Matsuura, Hiroshi Seno

Journal: Intern. Med.. 2018 Jan;57(2):209-212.

 

A 46-year-old man visited the emergency department of our hospital with a 3-day history of anal pain, hemorrhaging, and a slight fever. He had previously been diagnosed with protein C deficiency and was prescribed dabigatran, a direct oral anticoagulant. Contrast-enhanced computed ...

Last Updated: 31 Dec 1969

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Early cirrhosis in a young female with protein C deficiency: An extremely unusual case report with review.
 

Author(s): Nalini Bansal, Chhagan Bihari

Journal: Indian J Pathol Microbiol. ;59(3):413-6.

 

Protein C deficiency is a well recognized risk factor for development of venous thromboembolism but has never been reported to be associated with development of liver cirrhosis .We report a case of a 26 years old female who presented with multiple thrombosis involving superior mesenteric ...

Last Updated: 31 Dec 1969

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Shwachman-Bodian-Diamond syndrome (SBDS) protein deficiency impairs translation re-initiation from C/EBPα and C/EBPβ mRNAs.
 

Author(s): Kyungmin In, Mohamad A Zaini, Christine Müller, Alan J Warren, Marieke von Lindern, Cornelis F Calkhoven

Journal: Nucleic Acids Res.. 2016 05;44(9):4134-46.

 

Mutations in the Shwachman-Bodian-Diamond Syndrome (SBDS) gene cause Shwachman-Diamond Syndrome (SDS), a rare congenital disease characterized by bone marrow failure with neutropenia, exocrine pancreatic dysfunction and skeletal abnormalities. The SBDS protein is important for ribosome ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Protein C Deficiency" returned 6 free, full-text review articles on human participants. First 3 results:

Lupus protein-losing enteropathy patient with protein C and protein S deficiency-induced thrombosis: A case report with review of the literature.
 

Author(s): Ratchaya Lertnawapan, Dussadee Sakonlaya

Journal: Acta Reumatol Port. ;42(3):265-268.

 

A case report of SLE with PLE in an Asian female; presented with edema, pleural effusion, ascites and profound hypoalbuminemia. She also had severe protein C and protein S depletion from GI loss which caused extensive thrombosis. Her disease was refractory to the treatment with ...

Last Updated: 31 Dec 1969

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Protein C deficiency related obscure gastrointestinal bleeding treated by enteroscopy and anticoagulant therapy.
 

Author(s): Wei-Fan Hsu, Yuk-Ming Tsang, Chung-Jen Teng, Chen-Shuan Chung

Journal: World J. Gastroenterol.. 2015 Jan;21(3):1024-7.

 

Obscure gastrointestinal bleeding is an uncommonly encountered and difficult-to-treat clinical problem in gastroenterology, but advancements in endoscopic and radiologic imaging modalities allow for greater accuracy in diagnosing obscure gastrointestinal bleeding. Ectopic varices ...

Last Updated: 31 Dec 1969

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[Two cases of pulmonary thromboembolism associated with protein C and protein S deficiency and literature review].
 

Author(s): Fang Liu, Lanyan Zhu, Ping Chen, Zhihui Shi, Shaokun Liu

Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Sep;38(9):971-6.

 

To explore the clinical manifestations, diagnosis and treatment of pulmonary thromboembolism associated with protein C (PC)/protein S (PS) deficiency. Two male patients 29 and 26 years old diagnosed with PC deficiency and/or PS deficiency were retrospectively analyzed and related ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.