Protein S deficiency

Common Name(s)

Protein S deficiency

Protein S deficiency is a disorder that causes abnormal blood clotting. When someone bleeds, the blood begins a complicated series of rapid chemical reactions involving proteins called blood coagulation factors to stop the bleeding.  Other proteins in the blood, such as protein S, usually regulate these chemical reactions to prevent excessive clotting. When protein S is missing (deficient), clotting may not be regulated normally and affected individuals have an increased risk of forming a blood clot called a thrombosis.  People at risk to have protein S deficiency are those with an individual or family history of multiple blood clots in the veins.  Treatment may include taking medication known as blood thinners to decrease the chance of developing a blood clot.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Protein S deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Protein S deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Protein S deficiency" returned 124 free, full-text research articles on human participants. First 3 results:

Warfarin-induced skin necrosis in a patient with protein S deficiency.
 

Author(s): Ruana Fraga, Lucia Martins Diniz, Elton Almeida Lucas, Paulo Sergio Emerich

Journal: An Bras Dermatol. ;93(4):612-613.

 

Last Updated: 31 Dec 1969

Go To URL
Recurrent pulmonary embolism associated with deep venous thrombosis diagnosed as protein s deficiency owing to a novel mutation in PROS1: A case report.
 

Author(s): Xiaojie Huang, Fangfang Xu, Carmel Rebecca Assa, Laigen Shen, Bing Chen, Zhenjie Liu

Journal: Medicine (Baltimore). 2018 May;97(19):e0714.

 

Protein S (PS) deficiency that can be inherited or acquired is an independent risk factor for venous thromboembolism (VTE).

Last Updated: 31 Dec 1969

Go To URL
Venous thromboembolism associated with protein S deficiency due to Arg451* mutation in PROS1 gene: a case report and a literature review.
 

Author(s): Ewa Wypasek, Marek Karpinski, Martine Alhenc-Gelas, Anetta Undas

Journal: J. Genet.. 2017 Dec;96(6):1047-1051.

 

Protein S (PS) is a vitaminK-dependent glycoproteinwhich plays an important role in the regulation of blood coagulation. PS deficiency has been found in 1.5-7% of thrombophilic patients. Here, we report the first Polish case with PS deficiency caused by the p.Arg451* in the PROS1 ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Protein S deficiency" returned 4 free, full-text review articles on human participants. First 3 results:

Lupus protein-losing enteropathy patient with protein C and protein S deficiency-induced thrombosis: A case report with review of the literature.
 

Author(s): Ratchaya Lertnawapan, Dussadee Sakonlaya

Journal: Acta Reumatol Port. ;42(3):265-268.

 

A case report of SLE with PLE in an Asian female; presented with edema, pleural effusion, ascites and profound hypoalbuminemia. She also had severe protein C and protein S depletion from GI loss which caused extensive thrombosis. Her disease was refractory to the treatment with ...

Last Updated: 31 Dec 1969

Go To URL
Acquired pial and dural arteriovenous fistulae following superior sagittal sinus thrombosis in patients with protein S deficiency: a report of two cases.
 

Author(s): Shunji Matsubara, Koichi Satoh, Junichiro Satomi, Toshio Shigekiyo, Tomoya Kinouchi, Hajimu Miyake, Shinji Nagahiro

Journal: Neurol. Med. Chir. (Tokyo). 2014 ;54(3):245-52.

 

Two patients with protein S deficiency with acquired multiple pial and dural arteriovenous fistulae (AVFs) following superior sagittal sinus (SSS) thrombosis are reported. Case 1 is a 38-year-old male with protein S deficiency who developed generalized seizure due to SSS thrombosis. ...

Last Updated: 31 Dec 1969

Go To URL
[Two cases of pulmonary thromboembolism associated with protein C and protein S deficiency and literature review].
 

Author(s): Fang Liu, Lanyan Zhu, Ping Chen, Zhihui Shi, Shaokun Liu

Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Sep;38(9):971-6.

 

To explore the clinical manifestations, diagnosis and treatment of pulmonary thromboembolism associated with protein C (PC)/protein S (PS) deficiency. Two male patients 29 and 26 years old diagnosed with PC deficiency and/or PS deficiency were retrospectively analyzed and related ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov