Pseudobulbar affect

Common Name(s)

Pseudobulbar affect

Pseudobulbar affect (PBA) is a medical condition characterized by sudden and uncontrollable episodes of crying, laughing or other emotional displays. An episode of PBA can occur at any time, even in inappropriate social situations. PBA is common in stroke survivors or people with other neurologic conditions such as dementia, multiple sclerosis, Lou Gehrig’s disease (ALS) or traumatic brain injury. It is thought to affect more than 1 million people in the U.S. PBA is often mistaken for depression, causing it to be underdiagnosed, undertreated and sometimes treated inappropriately. Medications such as the combination of dextromethorphan and quinidine have been effective in treating this condition.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pseudobulbar affect" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pseudobulbar affect" returned 6 free, full-text research articles on human participants. First 3 results:

PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury.
 

Author(s): Flora M Hammond, David N Alexander, Andrew J Cutler, Stephen D'Amico, Rachelle S Doody, William Sauve, Richard D Zorowitz, Charles S Davis, Paul Shin, Fred Ledon, Charles Yonan, Andrea E Formella, Joao Siffert

Journal:

 

Phase 3 trials supporting dextromethorphan/quinidine (DM/Q) use as a treatment for pseudobulbar affect (PBA) were conducted in patients with amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS). The PRISM II study provides additional DM/Q experience with PBA secondary to ...

Last Updated: 31 Dec 1969

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Identification of pseudobulbar affect symptoms in Veterans with possible traumatic brain injury.
 

Author(s): Jennifer R Fonda, Phillip R Hunt, Regina E McGlinchey, James L Rudolph, William P Milberg, Matthew W Reynolds, Charles Yonan

Journal: J Rehabil Res Dev. 2015 ;52(7):839-49.

 

Pseudobulbar affect (PBA), a neurological syndrome characterized primarily by involuntary episodes of laughing and crying, can develop secondary to neurological conditions including traumatic brain injury (TBI). Veterans of the wars in Afghanistan and Iraq have an unprecedented risk ...

Last Updated: 31 Dec 1969

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Prevalence of pseudobulbar affect symptoms and clinical correlates in nursing home residents.
 

Author(s): Kevin Foley, R Tamara Konetzka, Anthony Bunin, Charles Yonan

Journal: Int J Geriatr Psychiatry. 2016 07;31(7):694-701.

 

Pseudobulbar affect (PBA) is a neurological disorder of emotional expression, characterized by uncontrollable episodes of crying or laughing in patients with certain neurological disorders affecting the brain. The purposes of this study were to estimate the prevalence of PBA in US ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pseudobulbar affect" returned 2 free, full-text review articles on human participants. First 3 results:

Enhancing Approaches to the Identification and Management of Pseudobulbar Affect.
 

Author(s): David W Crumpacker

Journal: J Clin Psychiatry. 2016 Sep;77(9):e1155.

 

Pseudobulbar affect (PBA) is a socially debilitating condition that primarily affects people with neurologic diseases, such as Alzheimer's disease or multiple sclerosis. This condition is characterized by uncontrolled, exaggerated expressions of laughing or crying-often when the situation ...

Last Updated: 31 Dec 1969

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Dextromethorphan/quinidine sulfate for pseudobulbar affect.
 

Author(s): Howard Rosen

Journal: Drugs Today. 2008 Sep;44(9):661-8.

 

A new agent containing a combination of dextromethorphan (DM) and quinidine (Q) is currently under development for the treatment of pseudobulbar affect (PBA). PBA is a disorder of emotional regulation, characterized by uncontrollable outbursts of laughing and/or crying that are disproportionate ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.