Psoriasis

Common Name(s)

Psoriasis

Psoriasis is a chronic (long-lasting) skin condition that causes cells to grow too quickly and results in red, scaly, and occasionally itchy patches on the skin. In normal skin, cells flake off from the surface and are replaced by new cells every four weeks. In people with psoriasis, new cells form and quickly move to the surface of the skin, forming thick patches (plaques) that typically appear on the elbows, knees, scalp, lower back, hands, or feet. These patches are usually dry and itchy. If scraped or picked, they can also bleed. In some cases of psoriasis, the areas where bones meet (joints) may also become swollen and stiff, which is called psoriatic arthritis. Psoriasis can be mild, causing small areas of rash, or severe, causing large areas of raised, red and loose plaques. Symptoms of psoriasis tend to come and go. Risk factors that can lead to the return of symptoms (flare-ups) include a dry climate, infections, stress, dry skin and certain medications.

The exact cause of psoriasis is unknown. However, it is thought to be an autoimmune disease, which means something causes the body’s immune system to attack itself, mistaking healthy cells for something foreign (from outside the body). It is believed that both genetic and environmental factors play a role in psoriasis. In order to diagnose psoriasis, your doctor will gather a medical history and perform a physical exam that focuses on the skin. Your doctor may also remove and examine a small piece of the affected skin (skin biopsy). There is no cure for psoriasis. However, there are many treatment options that may help control the symptoms. These include creams that can be applied to the surface of the skin (topical), oral medications, moisturizers, and light therapy. If you or your child have been diagnosed with psoriasis, talk with your doctor to decide which treatment option is best for you.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

Last Updated: 26 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

http://www.psoriasis.org/

Last Updated: 26 Jul 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
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General Resources

For scientists and medical professionals

Information about how to apply for National Psoriasis Foundation research grants and fellowships, our medical journal and other science-related materials for medical professionals.

Updated 15 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Psoriasis" returned 2666 free, full-text research articles on human participants. First 3 results:

IκBζ is a key transcriptional regulator of IL-36-driven psoriasis-related gene expression in keratinocytes.
 

Author(s): Anne Müller, André Hennig, Sebastian Lorscheid, Paula Grondona, Klaus Schulze-Osthoff, Stephan Hailfinger, Daniela Kramer

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2018 10;115(40):10088-10093.

 

Proinflammatory cytokine signaling in keratinocytes plays a crucial role in the pathogenesis of psoriasis, a skin disease characterized by hyperproliferation and abnormal differentiation of keratinocytes and infiltration of inflammatory cells. Although IL-17A and TNFα are effective ...

Last Updated: 31 Dec 1969

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Serum uric acid levels and hyperuricemia in patients with psoriasis: a hospital-based cross-sectional study.
 

Author(s): Xin-Yu Gui, Hong-Zhong Jin, Zhen-Jie Wang, Teng-Da Xu

Journal: An Bras Dermatol. ;93(5):761-763.

 

A hospital-based cross-sectional study was performed, including 117 psoriatic patients and 117 controls matched for age, gender, and body mass index. Psoriatic patients had higher levels of serum uric acid (6.25 ± 1.62 vs 5.71 ± 1.35 mg/dl; P=0.019) and significantly greater prevalence ...

Last Updated: 31 Dec 1969

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Metabolic syndrome and psoriasis: a study in 97 patients.
 

Author(s): Lana Bassi Ferdinando, Paula Kaori Fukumoto, Sarah Sanches, Lincoln Helder Zambaldi Fabricio, Thelma L Skare

Journal: Rev Assoc Med Bras (1992). 2018 Apr;64(4):368-373.

 

Psoriasis is associated with higher prevalence of metabolic syndrome (MS). The prevalence of MS varies according to the studied population as it suffers influence of genetics, aging, sedentary behaviour and diet.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Psoriasis" returned 464 free, full-text review articles on human participants. First 3 results:

Saliva as a Future Field in Psoriasis Research.
 

Author(s): Farah Asa'ad, Marco Fiore, Aniello Alfieri, Paolo Daniele Maria Pigatto, Chiara Franchi, Emilio Berti, Carlo Maiorana, Giovanni Damiani

Journal:

 

Psoriasis is a skin inflammatory disease characterized by an increased body of comorbidities, including parodontopathy. Despite the visibility of skin lesions, prognostic biomarkers, related to disease monitoring and therapeutic effectiveness, are still missing. Although several markers ...

Last Updated: 31 Dec 1969

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Prevalence and Possible Role of Species in Patients with Psoriasis: A Systematic Review and Meta-Analysis.
 

Author(s): Aldona Pietrzak, Ewelina Grywalska, Mateusz Socha, Jacek Roliński, Kinga Franciszkiewicz-Pietrzak, Lidia Rudnicka, Marcin Rudzki, Dorota Krasowska

Journal:

 

Although fungal colonization is implicated in the pathogenesis of psoriasis, its prevalence remains unclear. The aim of this systematic review and meta-analysis was to provide an overview on the prevalence of species in patients with psoriasis. We searched databases (MEDLINE, EMBASE, ...

Last Updated: 31 Dec 1969

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The Use and Safety of TNF Inhibitors during Pregnancy in Women with Psoriasis: A Review.
 

Author(s): Cæcilie Bachdal Johansen, Espen Jimenez-Solem, Ann Haerskjold, Freja Lærke Sand, Simon Francis Thomsen

Journal:

 

Psoriasis is a chronic immune-mediated inflammatory disease affecting women of childbearing potential. Biologic agents, notably Tumor Necrosis Factor inhibitors (TNFi), are the only current non-contraindicated systemic treatment option during pregnancy. TNFi comprised of complete ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 18 Oct 2018

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Last Updated: 5 Oct 2018

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The Effect of Riboflavin on Moderate to Severe Plaque Type Psoriasis
 

Status: Recruiting

Condition Summary: Psoriasis

 

Last Updated: 12 Jun 2018

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