Pulmonary alveolar microlithiasis

Common Name(s)

Pulmonary alveolar microlithiasis

Pulmonary alveolar microlithiasis is a rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades, and, generally, the diagnosis is incidental to clinical investigations unrelated to the specific disorder. Cases with early onset or rapid progression are rare. A 'sandstorm-appearing' chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age, and the disease follows a long-term progressive course, resulting in a slow deterioration of lung functions. About one-third of the reported cases are said to be familial (summary by {7:Corut et al., 2006}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pulmonary alveolar microlithiasis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pulmonary alveolar microlithiasis" returned 34 free, full-text research articles on human participants. First 3 results:

Pulmonary Alveolar Microlithiasis.
 

Author(s): Kevan Mehta, Sharon Dell, Catherine Birken, Suhail Al-Saleh

Journal: Can. Respir. J.. 2016 ;2016():4938632.

 

Pulmonary alveolar microlithiasis (PAM) is a rare autosomal recessive condition that is often asymptomatic despite significant changes in chest imaging. Diagnosis is often made when patients become symptomatic in adulthood. There are still no proven treatments, but earlier diagnosis ...

Last Updated: 22 Jul 2016

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Response to Disodium Etidronate Treatment in Three Siblings with Pulmonary Alveolar Microlithiasis.
 

Author(s): Erkan Cakir, Ahmet Hakan Gedik, Ali Özdemir, Nur Buyukpınarbasili, Mehmet Bilgin, Ilker Tolga Ozgen

Journal: Respiration. 2015 ;89(6):583-6.

 

Pulmonary alveolar microlithiasis (PAM) is a rare chronic genetic lung disease in childhood with no proven therapy. It is characterized by the deposition of calcium phosphate microliths within the alveolar air spaces. The effect of disodium etidronate (DE) treatment on PAM is controversial. ...

Last Updated: 26 Jun 2015

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[Pulmonary alveolar microlithiasis: Report of one case].
 

Author(s): Cristina Fernández F, Mauricio Salinas F, José Andrés de Grazia K, Juan Carlos Díaz P

Journal: Rev Med Chil. 2014 May;142(5):656-61.

 

Pulmonary alveolar microlithiasis is an extremely rare disease characterized by intra-alveolar accumulation of calcified spherical particles (called microliths), due to a mutation of the gene encoding a membrane transport protein of the alveolar surface. Most patients are asymptomatic ...

Last Updated: 27 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pulmonary alveolar microlithiasis" returned 8 free, full-text review articles on human participants. First 3 results:

Pulmonary Alveolar Microlithiasis.
 

Author(s): Atsushi Saito, Francis X McCormack

Journal: Clin. Chest Med.. 2016 09;37(3):441-8.

 

Pulmonary alveolar microlithiasis (PAM) is a genetic lung disorder that is characterized by the accumulation of calcium phosphate deposits in the alveolar spaces of the lung. Mutations in the type II sodium phosphate cotransporter, NPT2b, have been reported in patients with PAM. PAM ...

Last Updated: 12 Aug 2016

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Pulmonary Alveolar Microlithiasis - Clinico-Radiological dissociation - A case report with Radiological review.
 

Author(s): Sanjay Mhalasakant Khaladkar, Sushen Kumar Kondapavuluri, Anubhav Kamal, Raghav Kalra, Rajesh Kuber

Journal:

 

Pulmonary alveolar microlithiasis (PAM) is a rare chronic lung disease characterized by deposition of intra alveolar calcium and phosphate in bilateral lung parenchyma with predominance in lower and mid zones. Etiology and pathogenesis is not fully understood. However, mutation in ...

Last Updated: 20 May 2016

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Pulmonary alveolar microlithiasis: review of the 1022 cases reported worldwide.
 

Author(s): Giuseppe Castellana, Giorgio Castellana, Mattia Gentile, Roberto Castellana, Onofrio Resta

Journal: Eur Respir Rev. 2015 Dec;24(138):607-20.

 

Pulmonary alveolar microlithiasis (PAM) is a rare disease characterised by the widespread intra-alveolar accumulation of minute calculi called microliths. It is caused by mutation of the SLC34A2 gene encoding the type IIb sodium phosphate cotransporter in alveolar type II cells. The ...

Last Updated: 1 Dec 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.