Pustular psoriasis, generalized

Common Name(s)

Pustular psoriasis, generalized

Generalized pustular psoriasis (GPP) is a life-threatening disease characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein ({123260}) (summary by {6:Marrakchi et al., 2011}). GPP often presents in patients with existing or prior psoriasis vulgaris (PV; see {177900}); however, GPP can develop without a history of PV ({9:Sugiura et al., 2013}). Palmoplantar pustulosis and acrodermatitis continua of Hallopeau represent acral forms of pustular psoriasis that have historically been grouped with GPP (summary by {8:Setta-Kaffetzi et al., 2013}). GPP in association with sterile multifocal osteomyelitis and periostitis ({612852}) is caused by mutation in the IL1RN gene ({147679}). {2:Capon (2013)} noted that the percentage of GPP patients reported to be negative for mutation in IL36RN ranges from 51 to 84%, indicative of genetic heterogeneity in the generalized pustular form of psoriasis. For a discussion of genetic heterogeneity of psoriasis, see PSORS1 ({177900}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pustular psoriasis, generalized" for support, advocacy or research.

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Scientific Literature

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Clinical Trial Information This information is provided by ClinicalTrials.gov

An Efficacy and Safety of Guselkumab in Participants With Palmoplantar Pustulosis
 

Status: Recruiting

Condition Summary: Palmoplantar Pustulosis

 

Last Updated: 16 May 2017

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BI655130 Single Dose in Generalized Pustular Psoriasis
 

Status: Recruiting

Condition Summary: Psoriasis

 

Last Updated: 18 Sep 2017

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Initial Dosing of BI 655130 in Palmoplantar Pustulosis Patients
 

Status: Recruiting

Condition Summary: Psoriasis

 

Last Updated: 18 Sep 2017

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