Pyoderma gangrenosum

Common Name(s)

Pyoderma gangrenosum

Pyoderma gangrenosum is a rare, destructive inflammatory skin disease of which a painful nodule or pustule breaks down to form a progressively enlarging ulcer. Lesions may occur either in the absence of any apparent underlying disorder or in association with other diseases, such as ulcerative colitis, Crohn's disease, polyarthritis (an inflammation of several joints together), gammopathy, and other conditions . Pyoderma gangrenosum belongs to a group of skin diseases in which a common cellular denominator is the neutrophil. Neutrophils are a type of white blood cell or leukocyte which form an early line of defense against bacterial infections.  Each year in the United States, pyoderma gangrenosum occurs in about 1 person per 100.000 people.
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pyoderma gangrenosum" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pyoderma gangrenosum" returned 220 free, full-text research articles on human participants. First 3 results:

Two case reports of pyoderma gangrenosum and systemic lupus erythematosus: A rare but nonfortuitous association?
 

Author(s): Delphine Lebrun, Ailsa Robbins, Maxime Hentzien, Ségolène Toquet, Julie Plee, Anne Durlach, Jean-David Bouaziz, Firouzé Bani-Sadr, Amélie Servettaz

Journal: Medicine (Baltimore). 2018 Aug;97(34):e11933.

 

Pyoderma gangrenosum (PG), like other neutrophilic dermatosis, may be associated with a variety of systemic disorders including inflammatory bowel diseases, rheumatoid arthritis, and hematologic disorders. Conversely, the association between PG and systemic lupus erythematosus (SLE) ...

Last Updated: 31 Dec 1969

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PLECT or PPLECT? Granulomatous pyoderma gangrenosum in the differential diagnosis of the verrucous syndrome.
 

Author(s): Kenselyn Oppermann, Ariane Rubin Cocco, Renata Heck, Renan Rangel Bonamigo

Journal: An Bras Dermatol. ;93(4):605-607.

 

Pyoderma gangrenosum (PG) is an uncommon neutrophilic dermatosis, with variable clinical features, nonspecific histopathology and multifactorial pathogenesis, posing a challenging diagnosis for the dermatologist. Pyoderma gangrenosum is a diagnosis of exclusion and should be included ...

Last Updated: 31 Dec 1969

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Pyoderma Gangrenosum in Ulcerative Colitis.
 

Author(s): Giovanni Perricone, Marcello Vangeli

Journal: N. Engl. J. Med.. 2018 Jul;379(4):e7.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pyoderma gangrenosum" returned 23 free, full-text review articles on human participants. First 3 results:

Pyoderma Gangrenosum: An Uncommon Case Report and Review of the Literature.
 

Author(s): António Carlos Lemos, Debora Aveiro, Natália Santos, Vítor Marques, Luís Filipe Pinheiro

Journal: Wounds. 2017 Sep;29(9):E61-E69.

 

Pyoderma gangrenosum (PG) is a rare ulcerative condition that is diagnostically and therapeutically challenging, as debridement leads to ulcer deterioration (pathergy phenomenon); immunosuppression is considered the gold standard therapy.

Last Updated: 31 Dec 1969

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Oral Pyoderma Gangrenosum: Diagnosis, Treatment and Challenges: A Systematic Review.
 

Author(s): Caroline Bissonnette, Adel Kauzman, Gisele N Mainville

Journal: Head Neck Pathol. 2017 Dec;11(4):427-441.

 

Pyoderma gangrenosum (PG) is a distinctive ulcerative skin disorder of unknown etiology, associated with an underlying systemic disease in up to 70% of cases. The condition is characterized by the appearance of one or more necrotic ulcers with a ragged undermined violaceous border ...

Last Updated: 31 Dec 1969

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Wegener's granulomatosis and pyoderma gangrenosum--rare causes of facial ulcerations.
 

Author(s): Karolina Kędzierska, Krzysztof Sindrewicz, Tomasz Smektała, Magda Wiśniewska, Marek Masiuk, Ewelina Staniszewska, Katarzyna Sporniak-Tutak, Edyta Gołembiewska, Kazimierz Ciechanowski

Journal:

 

Pyoderma gangrenosum (PG) is caused by immune system dysfunction, and particularly improper functioning of neutrophils. At least half of all PG patients also suffer from autoimmunological diseases, one of which is Wegener granulomatosis (WG). The purpose of this article was to compare ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 28 Aug 2018

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Study on the Clinical Features, Comorbidities and Pathologies Associated With Pyoderma Gangrenosum
 

Status: Not yet recruiting

Condition Summary: Pyoderma Gangrenosum

 

Last Updated: 17 Aug 2018

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An Open-Label, Proof-of-Concept Study of Ixekizumab in the Treatment of Pyoderma Gangrenosum
 

Status: Recruiting

Condition Summary: Pyoderma Gangrenosum

 

Last Updated: 3 Apr 2018

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