Refractory asthma

Common Name(s)

Refractory asthma, Non-reversible asthma

Refractory (non-reversible) asthma is a severe form of asthma, which is a chronic inflammatory disease that causes the airways to swell, become narrow, and produce extra mucus. Symptoms include wheezing, coughing, shortness of breath and chest tightness. An asthma attack is an episode of severe asthma related symptoms that can be triggered by exercise, an environmental irritant, or an allergy. Some cases of asthma are mild and can be easily controlled with medication. However, people with refractory asthma have chronic asthma symptoms and frequent asthma attacks that do not respond to typical asthma medications. Individuals with refractory asthma require aggressive therapy, including steroid treatment. If you or your child has been diagnosed with refractory asthma, talk with your doctor to discuss the best treatment plan.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Refractory asthma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Refractory asthma" returned 35 free, full-text research articles on human participants. First 3 results:

LINX®, a novel treatment for patients with refractory asthma complicated by gastroesophageal reflux disease: a case report.
 

Author(s): Narin Sriratanaviriyakul, Celeste Kivler, Tamas J Vidovszky, Ken Y Yoneda, Nicholas J Kenyon, Susan Murin, Samuel Louie

Journal:

 

Gastroesophageal reflux disease is one of the most common comorbidities in patients with asthma. Gastroesophageal reflux disease can be linked to difficult-to-control asthma. Current management includes gastric acid suppression therapy and surgical antireflux procedures. The LINX® ...

Last Updated: 25 May 2016

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A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA).
 

Author(s): David Hodgson, John Anderson, Catherine Reynolds, Garry Meakin, Helen Bailey, Ian Pavord, Dominick Shaw, Tim Harrison

Journal: Thorax. 2015 Jun;70(6):559-65.

 

Some patients with refractory asthma have evidence of uncontrolled eosinophilic inflammation in the distal airways. While traditional formulations of inhaled steroids settle predominantly in the large airways, newer formulations with an extra-fine particle size have a more peripheral ...

Last Updated: 15 May 2015

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Low interleukin (IL)-18 levels in sputum supernatants of patients with severe refractory asthma.
 

Author(s): Nikoletta Rovina, Efrossini Dima, Petros Bakakos, Eleni Tseliou, Konstantina Kontogianni, Spyros Papiris, Antonia Koutsoukou, Nikolaos G Koulouris, Stelios Loukides

Journal: Respir Med. 2015 May;109(5):580-7.

 

Severe refractory asthma (SRA) is characterized by persistent asthma symptoms, amplified airway inflammation despite treatment with high dose inhaled steroids and increased airway bacterial colonization. Interleukin (IL)-18 is a pleiotropic pro-inflammatory cytokine that modulates ...

Last Updated: 9 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Refractory asthma" returned 4 free, full-text review articles on human participants. First 3 results:

Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK).
 

Author(s): Liam G Heaney, Ratko Djukanovic, Ashley Woodcock, Samantha Walker, John G Matthews, Ian D Pavord, Peter Bradding, Robert Niven, Chris E Brightling, Rekha Chaudhuri, Joseph R Arron, David F Choy, Douglas Cowan, Adel Mansur, Andrew Menzies-Gow, Ian Adcock, Kian F Chung, Chris Corrigan, Peter Coyle, Timothy Harrison, Sebastian Johnston, Peter Howarth, James Lordan, Ian Sabroe, Jeannette Bigler, Dirk Smith, Matthew Catley, Richard May, Lisa Pierre, Chris Stevenson, Glenn Crater, Frank Keane, Richard W Costello, Val Hudson, David Supple, Tim Hardman

Journal: Thorax. 2016 Feb;71(2):187-9.

 

The UK Refractory Asthma Stratification Programme (RASP-UK) will explore novel biomarker stratification strategies in severe asthma to improve clinical management and accelerate development of new therapies. Prior asthma mechanistic studies have not stratified on inflammatory phenotype ...

Last Updated: 15 Jan 2016

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Refractory asthma: mechanisms, targets, and therapy.
 

Author(s): J L Trevor, J S Deshane

Journal: Allergy. 2014 Jul;69(7):817-27.

 

Asthma is a common medical condition affecting 300 million people worldwide. Airway inflammation, smooth muscle bronchoconstriction leading to airflow obstruction, and mucous hypersecretion are clinical hallmarks of asthma. The NHLBI Expert Panel Report 3 recommends inhaled corticosteroids ...

Last Updated: 6 Jun 2014

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Severe refractory asthma: an update.
 

Author(s): Reinier R L Wener, Elisabeth H Bel

Journal: Eur Respir Rev. 2013 Sep;22(129):227-35.

 

Asthma is a heterogeneous disease in which adequate asthma control cannot be achieved in a substantial proportion despite currently available treatment possibilities. This subgroup has been defined as "severe refractory" asthma. Over the past years considerable progress has been made ...

Last Updated: 2 Sep 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Refractory Asthma Stratification Programme (RASP) Bronchoscopy Study
 

Status: Not yet recruiting

Condition Summary: Persistent Asthma

 

Last Updated: 2 Sep 2016

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Last Updated: 22 Sep 2016

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