Retinitis Pigmentosa 15

Common Name(s)

Retinitis Pigmentosa 15

X-linked retinitis pigmentosa (XLRP) is a severe form of inherited retinal degeneration that primarily affects the rod photoreceptors ({15:Demirci et al., 2002}). It typically causes an early-onset night blindness and loss of peripheral vision, often causing patients to become legally blind by the age of 30 to 40 years. In RP3, affected males have a severe phenotype, and carrier females show a wide spectrum of clinical features ranging from completely asymptomatic to severe RP ({22:Jin et al., 2007}). Mutation in the RPGR gene is believed to account for approximately 70% of XLRP ({38:Vervoort et al., 2000}). For a discussion of genetic heterogeneity of retinitis pigmentosa, see {268000}.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Retinitis Pigmentosa 15" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Retinitis Pigmentosa 15" returned 1 free, full-text research articles on human participants. First 3 results:

X-linked dominant cone-rod degeneration: linkage mapping of a new locus for retinitis pigmentosa (RP 15) to Xp22.13-p22.11.
 

Author(s): R E McGuire, L S Sullivan, S H Blanton, M W Church, J R Heckenlively, S P Daiger

Journal: Am. J. Hum. Genet.. 1995 Jul;57(1):87-94.

 

Retinitis pigmentosa is the name given to a heterogeneous group of hereditary retinal degenerations characterized by progressive visual field loss, pigmentary changes of the retina, abnormal electroretinograms, and, frequently, night blindness. In this study, we investigated a family ...

Last Updated: 15 Aug 1995

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Reviews from the PubMed Database

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The terms "Retinitis Pigmentosa 15" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 16 Nov 2017

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Gene Therapy for X-linked Retinitis Pigmentosa (XLRP) Retinitis Pigmentosa GTPase Regulator (RPGR)
 

Status: Recruiting

Condition Summary: X-Linked Retinitis Pigmentosa

 

Last Updated: 7 Sep 2017

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A Clinical Trial of Retinal Gene Therapy for X-linked Retinitis Pigmentosa
 

Status: Recruiting

Condition Summary: X-Linked Retinitis Pigmentosa

 

Last Updated: 13 Apr 2017

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