Richter syndrome

Common Name(s)

Richter syndrome

Richter syndrome is a rare condition in which chronic lymphocytic leukemia (CLL) changes into a fast-growing type of lymphoma. Symptoms of Richter syndrome can include fever, loss of weight and muscle mass, abdominal pain, and enlargement of the lymph nodes, liver, and spleen. Laboratory results may show anemia and low platelet counts (which can lead to easy bleeding and bruising).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Richter syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Richter syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Richter syndrome" returned 24 free, full-text research articles on human participants. First 3 results:

Classical Hodgkin lymphoma arising in a patient with chronic lymphocytic leukemia (Richter syndrome).
 

Author(s): Andrés E Quesada, Sergej Konoplev

Journal: Blood. 2017 11;130(19):2151.

 

Last Updated: 31 Dec 1969

Go To URL
Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cells by a novel NF-κB inhibitor.
 

Author(s): Tiziana Vaisitti, Federica Gaudino, Samedy Ouk, Maria Moscvin, Nicoletta Vitale, Sara Serra, Francesca Arruga, Johannes L Zakrzewski, Hsiou-Chi Liou, John N Allan, Richard R Furman, Silvia Deaglio

Journal: Haematologica. 2017 11;102(11):1878-1889.

 

IT-901 is a novel and selective NF-κB inhibitor with promising activity in pre-clinical models. Here we show that treatment of chronic lymphocytic leukemia cells (CLL) with IT-901 effectively interrupts NF-κB transcriptional activity. CLL cells exposed to the drug display elevated ...

Last Updated: 31 Dec 1969

Go To URL
Richter Syndrome With Extensive Isolated Pleural Extranodal Involvement: The Importance of PET/CT Imaging.
 

Author(s): Luis Gorospe Sarasúa, Ana Jaureguízar-Oriol, Carlos Almonacid-Sánchez, María Eugenia Rioja-Martín

Journal: Arch. Bronconeumol.. 2017 Nov;53(11):644-646.

 

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Richter syndrome" returned 2 free, full-text review articles on human participants. First 3 results:

Hematopoietic Cell Transplantation for Richter Syndrome.
 

Author(s): Jessica El-Asmar, Mohamed A Kharfan-Dabaja

Journal: Biol. Blood Marrow Transplant.. 2016 11;22(11):1938-1944.

 

Treatment combining chemotherapy with immunotherapy as well as novel targeted therapies have shown limited efficacy in Richter syndrome. Overall response rates after chemoimmunotherapy range from 43% to 67%, but remissions are generally short-lived. In chronic lymphocytic leukemia ...

Last Updated: 31 Dec 1969

Go To URL
Richter syndrome: biology, incidence, and therapeutic strategies.
 

Author(s): Apostolia-Maria Tsimberidou, Michael J Keating

Journal: Cancer. 2005 Jan;103(2):216-28.

 

Richter's transformation denotes the development of high-grade non-Hodgkin lymphoma, prolymphocytic leukemia, Hodgkin disease, or acute leukemia in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma. A search of published articles in Medline (PubMed) and abstracts ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 19 Mar 2018

Go to URL
Genomic and Proteomic Study of Richter Syndrome (CGPSR)
 

Status: Recruiting

Condition Summary: Richter Syndrome

 

Last Updated: 28 Aug 2018

Go to URL

Last Updated: 28 Aug 2017

Go to URL