Salmonella infection

Common Name(s)

Salmonella infection

Salmonella infection is a relatively common bacterial infection that typically affects the intestinal tract. Some people with salmonella infection have no symptoms while others may have diarrhea, fever, and abdominal cramps. Other symptoms include nausea, vomiting, headaches, and blood in the stool. If a person has symptoms from a salmonella infection, they typically start between 8 and 72 hours and last between 4 and 7 days. A salmonella infection is usually not life threatening, but it can be dangerous for individuals with weakened immune systems, including children, the elderly, and pregnant women. Some people with a salmonella infection can get severe diarrhea that may need urgent medical treatment. In some cases, the salmonella infection may spread beyond the intestinal tract and into the blood stream (bacteremia), which can cause life-threatening issues.

A salmonella infection is typically caused by eating food that is contaminated by fecal matter. Foods that are often contaminated include raw meat, raw poultry, raw seafood, and raw eggs, as well as contaminated fruits and vegetables. It is important for people to wash their hands before preparing food, as they may contaminate the food if they have salmonella on their hands. Risk factors include international travel and owning a bird or reptile. A salmonella infection is usually suspected based on your symptoms. Your doctor may use stool or blood testing to confirm the diagnosis. Treatments for salmonella infection include medications that stop the diarrhea (anti-diarrheal medication) and medications to treat the bacterial infection (antibiotics), but most cases get better on their own. If a person has severe diarrhea, they may need to be rehydrated by replacing fluids and electrolytes with a needle in the arm (IV). If you have been diagnosed with salmonella, talk with your doctor to discuss your treatment options.

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Condition Specific Organizations

Following organizations serve the condition "Salmonella infection" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Salmonella infection" returned 348 free, full-text research articles on human participants. First 3 results:

Salmonella Typhi Colonization Provokes Extensive Transcriptional Changes Aimed at Evading Host Mucosal Immune Defense During Early Infection of Human Intestinal Tissue.
 

Author(s): K P Nickerson, S Senger, Y Zhang, R Lima, S Patel, L Ingano, W A Flavahan, D K V Kumar, C M Fraser, C S Faherty, M B Sztein, M Fiorentino, A Fasano

Journal: EBioMedicine. 2018 May;31():92-109.

 

Commensal microorganisms influence a variety of host functions in the gut, including immune response, glucose homeostasis, metabolic pathways and oxidative stress, among others. This study describes how Salmonella Typhi, the pathogen responsible for typhoid fever, uses similar strategies ...

Last Updated: 31 Dec 1969

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Increased colon cancer risk after severe Salmonella infection.
 

Author(s): Lapo Mughini-Gras, Michael Schaapveld, Jolanda Kramers, Sofie Mooij, E Andra Neefjes-Borst, Wilfrid van Pelt, Jacques Neefjes

Journal:

 

Colon cancer constitutes one of the most frequent malignancies. Previous studies showed that Salmonella manipulates host cell signaling pathways and that Salmonella Typhimurium infection facilitates colon cancer development in genetically predisposed mice. This epidemiological study ...

Last Updated: 31 Dec 1969

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Efficacy and immunogenicity of a Vi-tetanus toxoid conjugate vaccine in the prevention of typhoid fever using a controlled human infection model of Salmonella Typhi: a randomised controlled, phase 2b trial.
 

Author(s): Celina Jin, Malick M Gibani, Maria Moore, Helene B Juel, Elizabeth Jones, James Meiring, Victoria Harris, Jonathan Gardner, Anna Nebykova, Simon A Kerridge, Jennifer Hill, Helena Thomaides-Brears, Christoph J Blohmke, Ly-Mee Yu, Brian Angus, Andrew J Pollard

Journal: Lancet. 2017 Dec;390(10111):2472-2480.

 

Salmonella enterica serovar Typhi (S Typhi) is responsible for an estimated 20 million infections and 200 000 deaths each year in resource poor regions of the world. Capsular Vi-polysaccharide-protein conjugate vaccines (Vi-conjugate vaccines) are immunogenic and can be used from ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Salmonella infection" returned 24 free, full-text review articles on human participants. First 3 results:

Methods to Illuminate the Role of Effector Proteins during Infection: A Review.
 

Author(s): Alexandra M Young, Amy E Palmer

Journal:

 

Intracellular bacterial pathogens like use secretion systems, such as the Type III Secretion System, to deliver virulence factors into host cells in order to invade and colonize these cells. virulence factors include a suite of effector proteins that remodel the host cell to facilitate ...

Last Updated: 31 Dec 1969

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The Role of Sphingolipids on Innate Immunity to Intestinal Salmonella Infection.
 

Author(s): Fu-Chen Huang

Journal:

 

spp. remains a major public health problem for the whole world. To reduce the use of antimicrobial agents and drug-resistant , a better strategy is to explore alternative therapy rather than to discover another antibiotic. Sphingolipid- and cholesterol-enriched lipid microdomains ...

Last Updated: 31 Dec 1969

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Vaccination against Salmonella Infection: the Mucosal Way.
 

Author(s): Rémi Gayet, Gilles Bioley, Nicolas Rochereau, Stéphane Paul, Blaise Corthésy

Journal:

 

subspecies includes several serovars infecting both humans and other animals and leading to typhoid fever or gastroenteritis. The high prevalence of associated morbidity and mortality, together with an increased emergence of multidrug-resistant strains, is a current global health ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Interaction Between Non-typhoid Salmonella, Host Microbiota, and Immune System During Acute Infection and Remission
 

Status: Recruiting

Condition Summary: Salmonella Infection Non-Typhoid

 

Last Updated: 2 Jul 2018

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Last Updated: 2 Aug 2018

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