Selective IgA deficiency

Common Name(s)

Selective IgA deficiency

Selective IgA deficiency refers to the complete or severe deficiency of IgA. This deficiency makes one more prone to infections, allergies, diarrhea, and autoimmune diseases. It is the most common type of primary immunodeficiency and is caused by a lack of mature B-lymphocytes. Why the B-lymphocytes fail to mature and produce IgA is not clear. Familial occurrence has been reported in the medical literature, some cases were suggestive of autosomal dominant inheritance, others of autosomal recessive inheritance.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Selective IgA deficiency" for support, advocacy or research.

Immune Deficiency Foundation

The Immune Deficiency Foundation is the national patient organization dedicated to improving the diagnosis, treatment and quality of life of persons with primary immunodeficiency diseases through advocacy, education and research.

Last Updated: 27 Aug 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Selective IgA deficiency" for support, advocacy or research.

Immune Deficiency Foundation

The Immune Deficiency Foundation is the national patient organization dedicated to improving the diagnosis, treatment and quality of life of persons with primary immunodeficiency diseases through advocacy, education and research.

http://www.primaryimmune.org

Last Updated: 27 Aug 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Selective IgA deficiency" returned 68 free, full-text research articles on human participants. First 3 results:

Population-Based Screening for Selective Immunoglobulin A (IgA) Deficiency in Lithuanian Children Using a Rapid Antibody-Based Fingertip Test.
 

Author(s): Vaidotas Urbonas, Jolita Sadauskaite, Rimante Cerkauskiene, Arvydas Kaminskas, Markku Mäki, Kalle Kurppa

Journal:

 

BACKGROUND Selective immunoglobulin A (IgA) deficiency is the most common inherited immunodeficiency disorder worldwide. An early diagnosis is advocated because of the increased risk of infections, autoimmune diseases, and allergic reactions. We investigated the usefulness of a rapid ...

Last Updated: 6 Dec 2016

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Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency.
 

Author(s): Paola G Bronson, Diana Chang, Tushar Bhangale, Michael F Seldin, Ward Ortmann, Ricardo C Ferreira, Elena Urcelay, Luis Fernández Pereira, Javier Martin, Alessandro Plebani, Vassilios Lougaris, Vanda Friman, Tomáš Freiberger, Jiri Litzman, Vojtech Thon, Qiang Pan-Hammarström, Lennart Hammarström, Robert R Graham, Timothy W Behrens

Journal: Nat. Genet.. 2016 Nov;48(11):1425-1429.

 

Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Europeans. Our genome-wide association study (GWAS) meta-analysis of 1,635 patients with IgAD and 4,852 controls identified four new significant (P < 5 × 10(-8)) loci and association with ...

Last Updated: 10 Oct 2016

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Burden of Skin Disease in Selective IgA Deficiency and Common Variable Immunodeficiency.
 

Author(s): G Gualdi, V Lougaris, M Baronio, M Vitali, G Tampella, D Moratto, P Tanghetti, P Monari, P Calzavara-Pinton, A Plebani

Journal: J Investig Allergol Clin Immunol. 2015 ;25(5):369-71.

 

Last Updated: 5 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Selective IgA deficiency" returned 3 free, full-text review articles on human participants. First 3 results:

Selective IgA deficiency in autoimmune diseases.
 

Author(s): Ning Wang, Nan Shen, Timothy J Vyse, Vidya Anand, Iva Gunnarson, Gunnar Sturfelt, Solbritt Rantapää-Dahlqvist, Kerstin Elvin, Lennart Truedsson, Bengt A Andersson, Charlotte Dahle, Eva Ortqvist, Peter K Gregersen, Timothy W Behrens, Lennart Hammarström

Journal: Mol. Med.. 2011 ;17(11-12):1383-96.

 

Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. It has previously been suggested to be associated with a variety of concomitant autoimmune diseases. In this review, we present data on the prevalence of IgAD in patients with Graves ...

Last Updated: 9 Apr 2012

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Selective IgA deficiency.
 

Author(s): Leman Yel

Journal: J. Clin. Immunol.. 2010 Jan;30(1):10-6.

 

Immunoglobulin A (IgA) deficiency is the most common primary immunodeficiency defined as decreased serum level of IgA in the presence of normal levels of other immunoglobulin isotypes. Most individuals with IgA deficiency are asymptomatic and identified coincidentally. However, some ...

Last Updated: 15 Feb 2010

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Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID).
 

Author(s): L Hammarström, I Vorechovsky, D Webster

Journal: Clin. Exp. Immunol.. 2000 May;120(2):225-31.

 

Last Updated: 27 Jun 2000

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.