Serotonin syndrome

Common Name(s)

Serotonin syndrome

Serotonin syndrome is a condition in which there is too much serotonin present in the body. Serotonin is a natural chemical that helps regulate mood, attention, emotions, and causes muscle contraction in the intestines. The body normally absorbs serotonin and stores it until it is needed, at which point it is released into the blood.

Decreased levels of serotonin are found in many patients with depression and anxiety, and these patients are often treated with medications that increase the amount of serotonin in the blood. Thus, a common cause of serotonin syndrome is from taking large doses of antidepressants or taking multiple different antidepressants at the same time. Serotonin syndrome may also be caused by other medications, herbal supplements, or illegal drugs that work by increasing serotonin levels in the blood. Individuals at the highest risk of developing serotonin syndrome include those who are taking new medications or new doses of their medications.

Symptoms of serotonin syndrome typically occur within hours of taking a drug. Individuals often experience an increased heart rate, restlessness, and confusion. The individual may experience heavy sweating, muscle twitching or rigidity, dilation of the pupils, shivering, headaches, and diarrhea. Symptoms often last for 1 to 3 days before they resolve. More severe cases of serotonin syndrome may involve high fever, irregular heartbeats, seizures, and loss of consciousness.

If you believe that you or someone around you may be experiencing serotonin syndrome, it is important to seek medical attention. Doctors will check drug levels, look for signs of infection, and monitor vital signs. Treatment depends on the severity and type of symptoms. While some individuals will not require treatment, others may require hospitalization. If you or your child is experiencing serotonin syndrome, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Serotonin syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Serotonin syndrome" returned 144 free, full-text research articles on human participants. First 3 results:

Dietary Supplement-Drug Interaction-Induced Serotonin Syndrome Progressing to Acute Compartment Syndrome.
 

Author(s): Yesha A Patel, Nino Marzella

Journal:

 

BACKGROUND Dietary supplements have been associated with an increase in emergency intervention as a result of unexpected adverse events. Limited resources and information on significant drug-drug interactions with dietary supplements and prescription medications have contributed to ...

Last Updated: 31 Dec 1969

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In Reply: Serotonin syndrome.
 

Author(s): Vishal Vashistha, Robert Z Wang, Sukhdeep Kaur, Gregory Rutecki

Journal: Cleve Clin J Med. 2017 05;84(5):342-343.

 

Last Updated: 31 Dec 1969

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To the Editor: Serotonin syndrome.
 

Author(s): Cielo Z Rose

Journal: Cleve Clin J Med. 2017 05;84(5):342.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Serotonin syndrome" returned 29 free, full-text review articles on human participants. First 3 results:

Regulation of the serotonin transporter in the pathogenesis of irritable bowel syndrome.
 

Author(s): Duo-Chen Jin, Hai-Long Cao, Meng-Que Xu, Si-Nan Wang, Yu-Ming Wang, Fang Yan, Bang-Mao Wang

Journal: World J. Gastroenterol.. 2016 Sep;22(36):8137-48.

 

Serotonin (5-HT) and the serotonin transporter (SERT) have earned a tremendous amount of attention regarding the pathogenesis of irritable bowel syndrome (IBS). Considering that enteric 5-HT is responsible for the secretion, motility and perception of the bowel, the involvement of ...

Last Updated: 31 Dec 1969

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Serotonin Syndrome Induced by Combined Use of Mirtazapine and Olanzapine Complicated with Rhabdomyolysis, Acute Renal Failure, and Acute Pulmonary Edema-A Case Report.
 

Author(s): Chi-Shun Wu, Show-Hwa Tong, Cheung-Ter Ong, Sheng-Feng Sung

Journal: Acta Neurol Taiwan. 2015 Dec;24(4):117-21.

 

Serotonin syndrome is a potentially life-threatening complication of serotonergic agents. Although mirtazapine is a relatively safe antidepressant and has a comparatively low incidence of side effects, it still could induce serotonin syndrome.

Last Updated: 31 Dec 1969

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Effectiveness of Selective Serotonin Reuptake Inhibitors for Irritable Bowel Syndrome.
 

Author(s): Thad Wilkins, Edward Agabin, Lindsay Blake

Journal: Am Fam Physician. 2015 Nov;92(9):Online.

 

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Real-world Evidence Study EvaLuating PAtient-Reported Outcomes With XERMELO
 

Status: Recruiting

Condition Summary: Carcinoid Syndrome

 

Last Updated: 18 Jul 2017

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Last Updated: 4 Dec 2017

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Cabozantinib S-malate in Treating Patients With Neuroendocrine Tumors Previously Treated With Everolimus That Are Locally Advanced, Metastatic, or Cannot Be Removed by Surgery
 

Status: Not yet recruiting

Condition Summary: Atypical Carcinoid Tumor; Carcinoid Tumor; Digestive System Neuroendocrine Neoplasm; Enterochromaffin Cell Serotonin-Producing Pancreatic Neuroendocrine Tumor; Functional Pancreatic Neuroendocrine Tumor; Intermediate Grade Lung Neuroendocrine Neoplasm; Low Grade Lung Neuroendocrine Neoplasm; Lung Atypical Carcinoid Tumor; Lung Carcinoid Tumor; Metastatic Digestive System Neuroendocrine Tumor G1; Neuroendocrine Neoplasm; Non-Functional Pancreatic Neuroendocrine Tumor; Pancreatic Neuroendocrine Tumor; Stage IIIA Digestive System Neuroendocrine Tumor AJCC v7; Stage IIIB Digestive System Neuroendocrine Tumor AJCC v7; Stage IV Digestive System Neuroendocrine Tumor AJCC v7

 

Last Updated: 15 Dec 2017

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