Serotonin syndrome

Common Name(s)

Serotonin syndrome

Serotonin syndrome is a condition in which there is too much serotonin present in the body. Serotonin is a natural chemical that helps regulate mood, attention, emotions, and causes muscle contraction in the intestines. The body normally absorbs serotonin and stores it until it is needed, at which point it is released into the blood.

Decreased levels of serotonin are found in many patients with depression and anxiety, and these patients are often treated with medications that increase the amount of serotonin in the blood. Thus, a common cause of serotonin syndrome is from taking large doses of antidepressants or taking multiple different antidepressants at the same time. Serotonin syndrome may also be caused by other medications, herbal supplements, or illegal drugs that work by increasing serotonin levels in the blood. Individuals at the highest risk of developing serotonin syndrome include those who are taking new medications or new doses of their medications.

Symptoms of serotonin syndrome typically occur within hours of taking a drug. Individuals often experience an increased heart rate, restlessness, and confusion. The individual may experience heavy sweating, muscle twitching or rigidity, dilation of the pupils, shivering, headaches, and diarrhea. Symptoms often last for 1 to 3 days before they resolve. More severe cases of serotonin syndrome may involve high fever, irregular heartbeats, seizures, and loss of consciousness.

If you believe that you or someone around you may be experiencing serotonin syndrome, it is important to seek medical attention. Doctors will check drug levels, look for signs of infection, and monitor vital signs. Treatment depends on the severity and type of symptoms. While some individuals will not require treatment, others may require hospitalization. If you or your child is experiencing serotonin syndrome, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Serotonin syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Serotonin syndrome" returned 153 free, full-text research articles on human participants. First 3 results:

Serotonin Syndrome Complicating Treatment of Ifosfamide Neurotoxicity With Methylene Blue.
 

Author(s): Matthew Snyder, Suhas Gangadhara, Andrew S Brohl, Steven Ludlow, Sowmya Nanjappa

Journal: Cancer Control. ;24(5):1073274817729070.

 

Methylene blue is a widely used treatment for ifosfamide neurotoxicity. We present a case of severe encephalopathy complicating ifosfamide-based therapy for recurrent retroperitoneal leiomyosarcoma. After treatment with methylene blue, the patient experienced clinical decompensation ...

Last Updated: 31 Dec 1969

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Malignant Syndrome and Serotonin Syndrome in a General Hospital Setting: Clinical Features, Frequency and Prognosis.
 

Author(s): Akiyuki Hiraga, Satoshi Kuwabara

Journal: Intern. Med.. 2017 Nov;56(21):2865-2869.

 

Objective The differences in the frequency and clinical features of malignant syndrome (MS) and serotonin syndrome (SS) in same population have only rarely been reported. To report the frequency and clinical features of MS and SS in a general hospital setting. Methods The clinical ...

Last Updated: 31 Dec 1969

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Dietary Supplement-Drug Interaction-Induced Serotonin Syndrome Progressing to Acute Compartment Syndrome.
 

Author(s): Yesha A Patel, Nino Marzella

Journal:

 

BACKGROUND Dietary supplements have been associated with an increase in emergency intervention as a result of unexpected adverse events. Limited resources and information on significant drug-drug interactions with dietary supplements and prescription medications have contributed to ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Serotonin syndrome" returned 31 free, full-text review articles on human participants. First 3 results:

Serotonin syndrome due to co-administration of linezolid and methadone.
 

Author(s): Antonio Mastroianni, Gianfranco Ravaglia

Journal: Infez Med. 2017 Sep;25(3):263-266.

 

Serotonin syndrome (SS), a potentially life-threatening adverse drug reaction caused by excessive serotonergic agonism in central and peripheral nervous system serotonergic receptors, may be caused by a single drug or a combination of drugs with serotonergic activity. The syndrome ...

Last Updated: 31 Dec 1969

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Serotonin syndrome: Preventing, recognizing, and treating it.
 

Author(s): Robert Z Wang, Vishal Vashistha, Sukhdeep Kaur, Nathan W Houchens

Journal: Cleve Clin J Med. 2016 Nov;83(11):810-817.

 

As the use of serotonergic agents to treat depression has increased, so too has the incidence of serotonin syndrome. We identify the common agents implicated in serotonin syndrome and the clinical tools to diagnose, manage, and prevent serotonergic toxicity.

Last Updated: 31 Dec 1969

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Regulation of the serotonin transporter in the pathogenesis of irritable bowel syndrome.
 

Author(s): Duo-Chen Jin, Hai-Long Cao, Meng-Que Xu, Si-Nan Wang, Yu-Ming Wang, Fang Yan, Bang-Mao Wang

Journal: World J. Gastroenterol.. 2016 Sep;22(36):8137-48.

 

Serotonin (5-HT) and the serotonin transporter (SERT) have earned a tremendous amount of attention regarding the pathogenesis of irritable bowel syndrome (IBS). Considering that enteric 5-HT is responsible for the secretion, motility and perception of the bowel, the involvement of ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Real-world Evidence Study EvaLuating PAtient-Reported Outcomes With XERMELO
 

Status: Recruiting

Condition Summary: Carcinoid Syndrome

 

Last Updated: 18 Jul 2017

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AMT-PET in Monitoring Telotristat Etiprate Treatment in Participants With Metastatic Well Differentiated Neuroendocrine Neoplasm
 

Status: Not yet recruiting

Condition Summary: Carcinoid Syndrome; Metastatic Nonfunctional Well Differentiated Neuroendocrine Neoplasm

 

Last Updated: 10 Apr 2018

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Cabozantinib S-malate in Treating Patients With Neuroendocrine Tumors Previously Treated With Everolimus That Are Locally Advanced, Metastatic, or Cannot Be Removed by Surgery
 

Status: Not yet recruiting

Condition Summary: Atypical Carcinoid Tumor; Carcinoid Tumor; Digestive System Neuroendocrine Neoplasm; Enterochromaffin Cell Serotonin-Producing Pancreatic Neuroendocrine Tumor; Functional Pancreatic Neuroendocrine Tumor; Intermediate Grade Lung Neuroendocrine Neoplasm; Low Grade Lung Neuroendocrine Neoplasm; Lung Atypical Carcinoid Tumor; Lung Carcinoid Tumor; Metastatic Digestive System Neuroendocrine Tumor G1; Neuroendocrine Neoplasm; Nonfunctional Pancreatic Neuroendocrine Tumor; Pancreatic Neuroendocrine Tumor; Stage IIIA Digestive System Neuroendocrine Tumor AJCC v7; Stage IIIB Digestive System Neuroendocrine Tumor AJCC v7; Stage IV Digestive System Neuroendocrine Tumor AJCC v7

 

Last Updated: 4 Jul 2018

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