Sertoli cell-only syndrome

Common Name(s)

Sertoli cell-only syndrome

Sertoli cell-only syndrome (SCO syndrome) is a condition of the testes that causes infertility in males due to having only Sertoli cells (cells that nurture immature sperm) lining the seminiferous tubules (tubes inside the testicles where sperm develop). Men typically learn they are affected between ages 20-40 when being evaluated for infertility and are found to have no sperm production (azoospermia). The diagnosis is made based on testicular biopsy findings. Other signs and symptoms are rare, but are secondary to the underlying condition causing SCO syndrome. Most cases are idiopathic (of unknown cause), but causes may include deletions in the azoospermia factor (AZF) region of the Y chromosome, or Y-chromosome microdeletions (referred to as Y chromosome infertility); Klinefelter syndrome; exposure to chemicals and toxins; history of radiation therapy; and history of severe trauma. There is not currently a known effective treatment for the condition. When no germ cells are visible in any seminiferous tubules it is considered SCO type I; if germ cells are present in a minority of tubules is it considered SCO type II.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sertoli cell-only syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Sertoli cell-only syndrome" returned 6 free, full-text research articles on human participants. First 3 results:

Sertoli Cell-Only Syndrome: Behind the Genetic Scenes.
 

Author(s): Katrien Stouffs, Alexander Gheldof, Herman Tournaye, Deborah Vandermaelen, Maryse Bonduelle, Willy Lissens, Sara Seneca

Journal: Biomed Res Int. 2016 ;2016():6191307.

 

Sertoli cell-only syndrome is defined by the complete absence of germ cells in testicular tissues and always results in male infertility. The aetiology often remains unknown. In this paper, we have investigated possible causes of Sertoli cell-only syndrome with a special focus on ...

Last Updated: 29 Feb 2016

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A PLK4 mutation causing azoospermia in a man with Sertoli cell-only syndrome.
 

Author(s): T Miyamoto, Y Bando, E Koh, A Tsujimura, Y Miyagawa, M Iijima, M Namiki, M Shiina, K Ogata, N Matsumoto, K Sengoku

Journal: Andrology. 2016 Jan;4(1):75-81.

 

About 15% of couples wishing to have children are infertile; approximately half these cases involve a male factor. Polo-like kinase 4 (PLK-4) is a member of the polo protein family and a key regulator of centriole duplication. Male mice with a point mutation in the Plk4 gene show ...

Last Updated: 19 Jan 2016

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Sperm retrieval and live birth rates in presumed Sertoli-cell-only syndrome in testis biopsy: a single centre experience.
 

Author(s): U Gul, T Turunc, B Haydardedeoglu, O Yaycioglu, B Kuzgunbay, H Ozkardes

Journal: Andrology. 2013 Jan;1(1):47-51.

 

We aimed to investigate sperm retrieval rates (SRR) by testicular sperm extraction (TESE), factors affecting SRR, and fertilization rate (FR), implantation rate (IR), clinical pregnancy rate (CPR) and live birth rate (LBR) in patients with presumed Sertoli-cell-only syndrome in testis ...

Last Updated: 21 Dec 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Sertoli cell-only syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.