Single Ventricle Defects

Common Name(s)

Single Ventricle Defects

Single ventricle defects are birth defects that affect one of the heart’s ventricle chambers. The heart consists of four chambers, and the ventricle chambers are the lower chambers through which blood flows out of the heart. The affected chamber might be smaller, underdeveloped, or missing a valve. One out of 5 every 100,000 newborns are affected by this condition, and males and females are affected equally. Symptoms include: blue coloring of the skin, lips, and nails, rapid or labored breathing, rapid heart rate, and cold or clammy skin. They can be diagnosed using various medical tests such as: chest x-rays, electrocardiograms (EKG), cardiac ultrasounds, cardiac catheterization, or cardiac MRIs. Single ventricle defects are some of the most complex heart defects, and almost always require surgery to repair.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Single Ventricle Defects" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Single Ventricle Defects" returned 5 free, full-text research articles on human participants. First 3 results:

Pharmacokinetics of intravenous sildenafil in children with palliated single ventricle heart defects: effect of elevated hepatic pressures.
 

Author(s): Kevin D Hill, Mario R Sampson, Jennifer S Li, Robert D Tunks, Scott R Schulman, Michael Cohen-Wolkowiez

Journal: Cardiol Young. 2016 Feb;26(2):354-62.

 

Aims Sildenafil is frequently prescribed to children with single ventricle heart defects. These children have unique hepatic physiology with elevated hepatic pressures, which may alter drug pharmacokinetics. We sought to determine the impact of hepatic pressure on sildenafil pharmacokinetics ...

Last Updated: 31 Dec 1969

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Perinatal outcome after prenatal diagnosis of single-ventricle cardiac defects.
 

Author(s): R S Beroukhim, K Gauvreau, O J Benavidez, C W Baird, T LaFranchi, W Tworetzky

Journal: Ultrasound Obstet Gynecol. 2015 Jun;45(6):657-63.

 

To investigate the perinatal outcome of cases with a prenatal diagnosis of single-ventricle cardiac defects, single ventricle being defined as a dominant right ventricle (RV) or left ventricle (LV), in which biventricular circulation was not possible.

Last Updated: 31 Dec 1969

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Two-ventricle repair for complex congenital heart defects palliated towards single-ventricle repair.
 

Author(s): Brijesh P Kottayil, Gopalraj S Sunil, Mahesh Kappanayil, Sweta Harish Mohanty, Edwin Francis, Balu Vaidyanathan, Rakhi Balachandran, Suresh G Nair, Raman Krishna Kumar

Journal: Interact Cardiovasc Thorac Surg. 2014 Mar;18(3):266-71.

 

Complex congenital heart defects that present earlier in life are sometimes channelled towards single-ventricle repair, because of anatomical or logistic challenges involved in two-ventricle correction. Given the long-term functional and survival advantage, we have been consciously ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Single Ventricle Defects" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 13 Dec 2016

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A Extension Study of Udenafil in Adolescents
 

Status: Recruiting

Condition Summary: Functional Single Ventricle Heart Disease

 

Last Updated: 12 Mar 2018

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Exclusive Human Milk Feeding in Infants With Single Ventricle Physiology
 

Status: Recruiting

Condition Summary: Congenital Heart Defect

 

Last Updated: 25 Oct 2017

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