Sirenomelia

Common Name(s)

Sirenomelia

Sirenomelia is a birth defect in which affected infants are born with a single lower extremity or with two legs that are fused together. The symptoms and physical findings associated with the condition vary greatly among affected individuals and may include malformations of the spine and skeletal system (commonly with vertebrae either absent or defective); absent or underdeveloped internal and external sex organs, rectum, kidneys and/or bladder; closed rectal opening (imperforate anus); and other abnormalities of the lower gastrointestinal tract. The exact cause is unknown, but it is believed to result from irregularities in early development of the blood circulating system within the embryo. Surgery has been successful in separating joined legs. Other treatment is symptomatic and supportive.
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sirenomelia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Sirenomelia" returned 22 free, full-text research articles on human participants. First 3 results:

Prenatal diagnosis of sirenomelia with anencephaly and craniorachischisis totalis: A case report study.
 

Author(s): Charalampos Theofanakis, Marianna Theodora, Michail Sindos, George Daskalakis

Journal: Medicine (Baltimore). 2017 Dec;96(50):e9020.

 

Sirenomelia and anencephaly are well-defined congenital malformations that usually occur independently.

Last Updated: 31 Dec 1969

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Sirenomelia or mermaid syndrome.
 

Author(s): Rahul Saxena, Archana Puri

Journal: Indian J. Med. Res.. 2015 Apr;141(4):495.

 

Last Updated: 31 Dec 1969

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Sirenomelia type VI (sympus apus) in one of dizygotic twins at Chiang Mai University Hospital.
 

Author(s): Kwannapas Nokeaingtong, Sirirat Kaewchai, Pannee Visrutaratna, Varangthip Khuwuthyakorn

Journal:

 

Those born with sirenomelia, a rare congenital anomaly, have features resembling a mermaid. Characteristics of sirenomelia are a single lower limb, sacral and pelvic bone defects, and anorectal and urogenital malformations. There is an increased incidence of sirenomelia in males and ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Sirenomelia" returned 6 free, full-text review articles on human participants. First 3 results:

[Sirenomelia (Mermaid syndrome): description of the first Congolese cases and review of the literature].
 

Author(s): Toni Kasole Lubala, Olivier Mukuku, Augustin Mulangu Mutombo

Journal:

 

Last Updated: 31 Dec 1969

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Sirenomelia: an epidemiologic study in a large dataset from the International Clearinghouse of Birth Defects Surveillance and Research, and literature review.
 

Author(s): Iêda M Orioli, Emmanuelle Amar, Jazmin Arteaga-Vazquez, Marian K Bakker, Sebastiano Bianca, Lorenzo D Botto, Maurizio Clementi, Adolfo Correa, Melinda Csaky-Szunyogh, Emanuele Leoncini, Zhu Li, Jorge S López-Camelo, R Brian Lowry, Lisa Marengo, María-Luisa Martínez-Frías, Pierpaolo Mastroiacovo, Margery Morgan, Anna Pierini, Annukka Ritvanen, Gioacchino Scarano, Elena Szabova, Eduardo E Castilla

Journal: Am J Med Genet C Semin Med Genet. 2011 Nov;157C(4):358-73.

 

Sirenomelia is a very rare limb anomaly in which the normally paired lower limbs are replaced by a single midline limb. This study describes the prevalence, associated malformations, and maternal characteristics among cases with sirenomelia. Data originated from 19 birth defect surveillance ...

Last Updated: 31 Dec 1969

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A clinical and experimental overview of sirenomelia: insight into the mechanisms of congenital limb malformations.
 

Author(s): Carlos Garrido-Allepuz, Endika Haro, Domingo González-Lamuño, María Luisa Martínez-Frías, Federica Bertocchini, Maria A Ros

Journal: Dis Model Mech. 2011 May;4(3):289-99.

 

Sirenomelia, also known as sirenomelia sequence, is a severe malformation of the lower body characterized by fusion of the legs and a variable combination of visceral abnormalities. The causes of this malformation remain unknown, although the discovery that it can have a genetic basis ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sup-Icu RENal (SIREN)
 

Status: Recruiting

Condition Summary: Critical Illness; Acute Kidney Injury; End-stage Renal Disease; Renal Replacement Therapy; Proton Pump Inhibitor

 

Last Updated: 9 Mar 2018

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