Sjogren's Syndrome

Common Name(s)

Sjogren's Syndrome

Sjogren's syndrome is an autoimmune disease which most commonly causes dry eyes and mouth. Our immune system protects us against infections from viruses and bacteria. Sometimes a person’s immune system attacks the person’s own tissues and organs by mistake. In this case, the immune system attacks the glands which produce moisture, especially those which produce tears and saliva. In addition to dry eyes and mouth, other symptoms may include dry skin, skin rashes, chronic dry cough, thyroid problems, joint and muscle pain, vaginal dryness and numbness and tingling in the arms and legs. The syndrome may also make the person feel very tired. Other complications may include vision and dental problems as well as more serious damage to the liver, kidneys or lungs. A small percentage of people with Sjogren’s develop lymphoma. Overall all symptoms may stay the same or worsen with time and may range from mild to debilitating (unable to do daily tasks). About half the time, a person with Sjogren’s syndrome will also have another autoimmune disease such as arthritis, lupus or scleroderma. Sjogren's syndrome may occur at any age, but is more common in women and people above the age of 40 years old. The cause of Sjorgren’s syndrome is unknown but may be a combination of genetics and bacterial or viral infection. Diagnosis is usually made through a physical exam, special test of the eyes and mouth and blood tests. Treatments for this condition depend on the symptoms present. Dry mouth and eyes may be treated with medications. Medication is also available to help lessen the joint and muscle pain, suppress the immune system and decrease inflammation or swelling. Early diagnosis and treatment may help prevent the more serious complications. Talk with your doctor if you or a family member has been diagnosed with Sjogren’s syndrome to decide on the best treatment. Support groups are also a good source of support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sjogren's Syndrome" for support, advocacy or research.

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Ben's Friends

Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.

Last Updated: 11 Jul 2016

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

Last Updated: 18 Apr 2010

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Sjögren's Syndrome Foundation, Inc.

The Foundation's mission is to: •Educate patients and their families about Sjögren's. •Increase public and professional awareness of Sjögren's. •Encourage research into new treatments and a cure.

Last Updated: 30 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sjogren's Syndrome" for support, advocacy or research.

Logo
Ben's Friends

Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.

http://www.bensfriends.org

Last Updated: 11 Jul 2016

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

View Details
International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

http://www.sclero.org/

Last Updated: 18 Apr 2010

View Details
Sjögren's Syndrome Foundation, Inc.

The Foundation's mission is to: •Educate patients and their families about Sjögren's. •Increase public and professional awareness of Sjögren's. •Encourage research into new treatments and a cure.

http://www.sjogrens.org

Last Updated: 30 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Sjogren's Syndrome" returned 1321 free, full-text research articles on human participants. First 3 results:

Prevalence of inflammatory back pain and radiologic sacroiliitis is increased in patients with primary Sjögren's syndrome.
 

Author(s): Rafet Eren, Meryem Can, Fatma Alibaz-Öner, Sibel Yilmaz-Oner, Baris Yilmazer, Ayse Cefle, Haner Direskeneli, Pamir Atagündüz

Journal:

 

The prevalence of Sjögren's syndrome (SS) in patients with the diagnosis of SpA has been reported to be higher than normal population. Yet, the vice-versa is unclear. In this study, we aimed to investigate the prevalence of IBP, radiologic sacroiliitis and SpA in patients with primary SS.

Last Updated: 31 Dec 1969

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Customary practices in the monitoring of dry eye disease in Sjogren's syndrome.
 

Author(s): Mira Acs, Barbara Caffery, Melissa Barnett, Charles Edmonds, Larisa Johnson-Tong, Richard Maharaj, Bart Pemberton, Dominik Papinski, Jennifer Harthan, Sruthi Srinivasan

Journal: J Optom. ;11(4):232-241.

 

Diagnostic testing for dry eye disease (DED) in Sjogren's syndrome (SS) is well described. Little is published about monitoring this systemic autoimmune DED. We analyzed the SS related DED tests used in North American optometric practices and compared academic settings to private practice settings.

Last Updated: 31 Dec 1969

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Expression of Gq Is Decreased in Lymphocytes from Primary Sjögren's Syndrome Patients and Related to Increased IL-17A Expression.
 

Author(s): Yuechi Sun, Ying Wang, Shiju Chen, Guihua Fan, Junhui Zhang, Fan Dai, Hongyan Qian, Yuan Liu, Guixiu Shi

Journal:

 

Primary Sjögren's syndrome (pSS) is a rheumatic disease characterized by the destruction of salivary and lacrimal glands, and its pathogenesis mechanism remains unclear. Gq is the -subunit of the heterotrimeric Gq protein. Researches demonstrated that Gq was involved in the pathogenesis ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Sjogren's Syndrome" returned 146 free, full-text review articles on human participants. First 3 results:

MicroRNA in Sjögren's Syndrome: Their Potential Roles in Pathogenesis and Diagnosis.
 

Author(s): M Reale, C D'Angelo, E Costantini, M Laus, A Moretti, A Croce

Journal:

 

Sjögren's syndrome (SS) or sicca syndrome was described by Swedish ophthalmologist Sjögren in the year 1933 for the first time. The etiology of the SS is multifunctional and includes a combination of genetic predisposition and environmental as well as epigenetic factors. It is an ...

Last Updated: 31 Dec 1969

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Sjogren's syndrome complicating pancytopenia, cerebral hemorrhage, and damage in nervous system: A case report and literature review.
 

Author(s): Wenqing Yu, Wei Qu, Zhiyong Wang, Chunhong Xin, Rui Jing, Yinghui Shang, Huilin Zou, Hua Wang, Sizhou Feng

Journal: Medicine (Baltimore). 2017 Dec;96(50):e8542.

 

Sjogren's syndrome(SS) is a chronic autoimmune disease, which damages exocrine glands especially salivary and lacrimal glands, with xerostomia and xerophthalmia as common symptoms.

Last Updated: 31 Dec 1969

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Dental implants in Sjögren's syndrome patients: A systematic review.
 

Author(s): Daniel Almeida, Katia Vianna, Patrícia Arriaga, Vittorio Moraschini

Journal:

 

The Sjögren's syndrome (SS) is a chronic autoimmune disease that affects salivation and consequently the health of oral tissues. The aim of this systematic review was to investigate the implant survival rate, marginal bone loss (MBL) and biological complications of dental implants in SS patients.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Implantology and Sjögren's Syndrome
 

Status: Recruiting

Condition Summary: Sjogren's Syndrome

 

Last Updated: 9 May 2017

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Study of Iguratimod in Sjögren's Syndrome
 

Status: Recruiting

Condition Summary: Sjogren's Syndrome

 

Last Updated: 15 Jan 2017

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A Study of INCB050465 in Primary Sjögren's Syndrome
 

Status: Recruiting

Condition Summary: Primary Sjögren's Syndrome

 

Last Updated: 16 Oct 2018

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