Spermatogenesis arrest

Common Name(s)

Spermatogenesis arrest

Azoospermia, a condition in which there are no sperm present in the ejaculate, has historically been divided into 2 broad categories, obstructive (e.g., {277180}) and nonobstructive. Among the genetically based, inherited nonobstructive causes are defects of spermatogenesis, which may interrupt the development of the sperm at various stages, either before (e.g., {415000}) or during meiosis. SPGF4 is a form of azoospermia due to perturbations of meiosis. For a discussion of phenotypic and genetic heterogeneity of spermatogenic failure, see SPGF1 ({258150}). Recurrent Pregnancy Loss Miscarriage, the commonest complication of pregnancy, is the spontaneous loss of a pregnancy before the fetus has reached viability. The term therefore includes all pregnancy losses from the time of conception until 24 weeks' gestation. Recurrent miscarriage, defined as 3 or more consecutive pregnancy losses, affects about 1% of couples; when defined as 2 or more losses, the scale of the problem increases to 5% of all couples trying to conceive (summary by {6:Rai and Regan, 2006}). Pregnancy losses have traditionally been designated 'spontaneous abortions' if they occur before 20 weeks' gestation and 'stillbirths' if they occur after 20 weeks. Subtypes of spontaneous abortions can be further distinguished on the basis of embryonic development and include anembryonic loss in the first 5 weeks after conception (so-called 'blighted ovum'), embryonic loss from 6 to 9 weeks' gestation, and fetal loss from 10 weeks' gestation through the remainder of the pregnancy. These distinctions are important because the causes of pregnancy loss vary over gestational ages, with anembryonic losses being more likely to be associated with chromosomal abnormalities, for example. Possible etiologies for recurrent pregnancy loss include uterine anatomic abnormalities, cytogenetic abnormalities in the parents or fetus, single gene disorders, thrombophilic conditions, and immunologic or endocrine factors as well as environmental or infectious agents (summary by {8:Warren and Silver, 2008}). For a discussion of genetic heterogeneity of recurrent pregnancy loss, see RPRGL1 ({614389}).
 

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Condition Specific Organizations

Following organizations serve the condition "Spermatogenesis arrest" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spermatogenesis arrest" returned 1 free, full-text research articles on human participants. First 3 results:

Oral clonidine advances spermatogenesis in oligozoospermic patients with spermatogenetic maturation arrest.
 

Author(s): Hiroshi Terada, Kimio Fujita, Atsushi Otsuka, Hitoshi Shinbo, Soichi Mugiya, Seiichiro Ozono

Journal: Int. J. Urol.. 2005 Sep;12(9):815-20.

 

Growth hormone (GH) plays an important role in the pubertal development of males and females, and influences the male reproductive function after puberty. The purpose of this study was to investigate the cause of GH deficiency in infertile men with spermatogenetic maturation arrest ...

Last Updated: 5 Oct 2005

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The terms "Spermatogenesis arrest" returned 0 free, full-text review articles on human participants.

 
 
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