Sphingolipidosis

Common Name(s)

Sphingolipidosis

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sphingolipidosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Sphingolipidosis" returned 4 free, full-text research articles on human participants. First 3 results:

Visualization of the heterogeneous membrane distribution of sphingomyelin associated with cytokinesis, cell polarity, and sphingolipidosis.
 

Author(s): Asami Makino, Mitsuhiro Abe, Motohide Murate, Takehiko Inaba, Neval Yilmaz, Françoise Hullin-Matsuda, Takuma Kishimoto, Nicole L Schieber, Tomohiko Taguchi, Hiroyuki Arai, Gregor Anderluh, Robert G Parton, Toshihide Kobayashi

Journal: FASEB J.. 2015 Feb;29(2):477-93.

 

Sphingomyelin (SM) is a major sphingolipid in mammalian cells and is reported to form specific lipid domains together with cholesterol. However, methods to examine the membrane distribution of SM are limited. We demonstrated in model membranes that fluorescent protein conjugates of ...

Last Updated: 4 Feb 2015

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Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells.
 

Author(s): Maria Laura Martin, Gerhard Liebisch, Stefan Lehneis, Gerd Schmitz, María Alonso-Sande, Joan Bestard-Escalas, Daniel H Lopez, José Manuel García-Verdugo, Mario Soriano-Navarro, Xavier Busquets, Pablo V Escribá, Gwendolyn Barceló-Coblijn

Journal: J. Lipid Res.. 2013 May;54(5):1457-65.

 

The mechanism of action of 2-hydroxyoleic acid (2OHOA), a potent antitumor drug, involves the rapid and specific activation of sphingomyelin synthase (SMS), leading to a 4-fold increase in SM mass in tumor cells. In the present study, we investigated the source of the ceramides required ...

Last Updated: 10 Apr 2013

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Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells.
 

Author(s): Matts D Linder, Riikka-Liisa Uronen, Maarit Hölttä-Vuori, Peter van der Sluijs, Johan Peränen, Elina Ikonen

Journal: Mol. Biol. Cell. 2007 Jan;18(1):47-56.

 

The mechanisms by which low-density lipoprotein (LDL)-cholesterol exits the endocytic circuits are not well understood. The process is defective in Niemann-Pick type C (NPC) disease in which cholesterol and sphingolipids accumulate in late endosomal compartments. This is accompanied ...

Last Updated: 28 Dec 2006

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Sphingolipidosis" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

LYSO-PROVE - Determine the Prognostic Value of Lyso-Gb1 for Monitoring the Progress of Gaucher Disease
 

Status: Recruiting

Condition Summary: Lysosomal Storage Diseases; Gaucher Disease; Sphingolipidoses

 

Last Updated: 4 May 2017

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Biomarker for Gaucher Disease
 

Status: Recruiting

Condition Summary: Lysosomal Storage Diseases; Gaucher Disease; Sphingolipidoses

 

Last Updated: 3 May 2017

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Biomarker for Metachromatic Leukodystrophy Disease
 

Status: Recruiting

Condition Summary: Leukodystrophy, Metachromatic; Hereditary Central Nervous System Demyelinating Diseases; Brain Diseases, Metabolic, Inborn; Sphingolipidoses; Lysosomal Storage Diseases, Nervous System

 

Last Updated: 3 May 2017

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