Splenomegaly

Common Name(s)

Splenomegaly

Splenomegaly is a condition in which an individual’s spleen is larger than normal. The spleen is an organ located in the left upper abdomen that filters red blood cells and helps protect the body against certain types of infections. An enlarged spleen is generally caused by infection, blood diseases, liver disease, or cancer. People at the highest risk of experiencing splenomegaly are those who have an active infection, have a metabolic disorder affecting the spleen or liver, or are exposed to malaria. The spleen of an affected individual may be felt by palpation during a physical examination. After splenomegaly is diagnosed, medical imaging and blood tests are often performed to help determine the cause and direct any treatment.

Individuals affected by splenomegaly may experience abdominal pain on the upper left side of the abdomen, hiccups, and difficulty eating large meals. Other symptoms include fatigue, more frequent bleeding, and repeated infections. Individuals with splenomegaly will often also have anemia, or a low number of circulating red blood cells. When the spleen is enlarged, healthy red blood cells are filtered in addition to old red blood cells. This decreases the number of healthy red blood cells in the bloodstream. If the spleen becomes too large, parts of the spleen may not receive enough blood supply and can be damaged. Complications of splenomegaly include severe infection or a ruptured spleen, which can be fatal.

For individuals with an enlarged spleen, physical activity should be avoided to prevent trauma that could lead to rupture. Treatment of splenomegaly will vary based on the cause. Antibiotics are used to treat any ongoing infections or to help prevent additional infections. In severe cases, part or all of the spleen may be surgically removed (splenectomy). If you or your child has been diagnosed with splenomegaly, talk to your doctor about the most appropriate treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Splenomegaly" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Splenomegaly" returned 213 free, full-text research articles on human participants. First 3 results:

A case of massive splenomegaly due to chronic myeloproliferative neoplasm.
 

Author(s): Zachary G Jacobs, Bongani Kaimila, Peter M Wasswa, Thuy Bui

Journal: Malawi Med J. 2018 03;30(1):46-48.

 

Last Updated: 31 Dec 1969

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Ruxolitinib for the treatment of inadequately controlled polycythemia vera without splenomegaly: 80-week follow-up from the RESPONSE-2 trial.
 

Author(s): Martin Griesshammer, Guray Saydam, Francesca Palandri, Giulia Benevolo, Miklos Egyed, Jeannie Callum, Timothy Devos, Serdar Sivgin, Paola Guglielmelli, Caroline Bensasson, Mahmudul Khan, Julian Perez Ronco, Francesco Passamonti

Journal: Ann. Hematol.. 2018 Sep;97(9):1591-1600.

 

RESPONSE-2 is a phase 3 study comparing the efficacy and safety of ruxolitinib with the best available therapy (BAT) in hydroxyurea-resistant/hydroxyurea-intolerant polycythemia vera (PV) patients without palpable splenomegaly. This analysis evaluated the durability of the efficacy ...

Last Updated: 31 Dec 1969

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Fever of unknown origin and splenomegaly: A case report of blood culture negative endocarditis.
 

Author(s): Maria Livia Burzo, Mariangela Antonelli, Giovanni Pecorini, Angela M R Favuzzi, Raffaele Landolfi, Andrea Flex

Journal: Medicine (Baltimore). 2017 Dec;96(50):e9197.

 

Fever of unknown origin (FUO) can be determined by different conditions among which infectious diseases represent the main cause.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Splenomegaly" returned 11 free, full-text review articles on human participants. First 3 results:

Understanding Splenomegaly in Myelofibrosis: Association with Molecular Pathogenesis.
 

Author(s): Moo-Kon Song, Byeong-Bae Park, Ji-Eun Uhm

Journal:

 

Myelofibrosis (MF) is a clinical manifestation of chronic BCR-ABL1-negative chronic myeloproliferative neoplasms. Splenomegaly is one of the major clinical manifestations of MF and is directly linked to splenic extramedullary hematopoiesis (EMH). EMH is associated with abnormal trafficking ...

Last Updated: 31 Dec 1969

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Turf wars: exploring splenomegaly in sickle cell disease in malaria-endemic regions.
 

Author(s): Venée N Tubman, Julie Makani

Journal: Br. J. Haematol.. 2017 06;177(6):938-946.

 

Sickle cell disease (SCD) is a group of recessively inherited disorders of erythrocyte function that presents an ongoing threat to reducing childhood and adult morbidity and mortality around the world. While decades of research have led to improved survival for SCD patients in wealthy ...

Last Updated: 31 Dec 1969

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The hyper-reactive malarial splenomegaly: a systematic review of the literature.
 

Author(s): Stefania Leoni, Dora Buonfrate, Andrea Angheben, Federico Gobbi, Zeno Bisoffi

Journal:

 

The hyper-reactive malarial splenomegaly syndrome (HMS) is a leading cause of massive splenomegaly in malaria-endemic countries. HMS is caused by a chronic antigenic stimulation derived from the malaria parasite. Classic Fakunle's major criteria for case definition are: persistent ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

CINC424A2X01B Rollover Protocol
 

Status: Recruiting

Condition Summary: Splenomegaly

 

Last Updated: 2 Feb 2018

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The Use of Point-of-Care Ultrasound in the Diagnosis of Acute Infectious Mononucleosis in the Emergency Department
 

Status: Recruiting

Condition Summary: Infectious Mononucleosis; Splenomegaly

 

Last Updated: 2 Mar 2018

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Single-Arm Study of the Efficacy and Safety of Oral Rigosertib in Patients With Myelofibrosis (MF) and Anemia
 

Status: Recruiting

Condition Summary: Leukemia; Myelofibrosis; Anemia; Splenomegaly

 

Last Updated: 2 Nov 2018

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