Spondyloarthritis

Common Name(s)

Spondyloarthritis, Spondyloarthropathy

Spondyloarthritis (or spondyloarthropathy) is a group of inflammatory diseases that cause arthritis in the sites where tendons and ligaments attach to bones (entheses). There are six forms of spondyloarthritis. The most common is ankylosing spondylitis, which mainly affects the spine. Other diseases in the spondyloarthritis family include axial spondyloarthritis (which affects mainly the spine and pelvic joints), peripheral spondyloarthritis (which affects mostly the arms and legs), reactive arthritis (Reiter’s syndrome), psoriatic arthritis, and enteropathic arthritis/spondylitis associated with inflammatory bowel diseases.

Signs and symptoms of spondyloarthritis varies depending on the disease. However, symptoms typically present with redness and swelling (inflammation) that causes pain and stiffness, usually in the spine. Some forms can affect the hands, feet, arms and legs. Another symptom includes destruction of bone that causes spine abnormalities (deformity). Additional complications of spondyloarthritis may include eye inflammation, compression fractures and heart problems. Symptoms usually begin around late adolescence or early adulthood. The exact cause of the spondyloarthritis group of diseases is unknown. They are believed to be due to a combination of genetic and environmental factors. Individuals with the HLA-B27 form of the HLA-B gene are at greater risk of developing ankylosing spondylitis, the most common type of spondyloarthritis.

To diagnose spondyloarthritis, your doctor will gather a medical history and perform a physical exam. In addition, they may collect images of the affected areas. There is no cure for spondyloarthritis, but treatment can include medications to decrease pain. If you or your child has been diagnosed with spondyloarthritis, talk with your doctor to discuss the current treatment options. Support groups can provide additional information and connect you with others.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Spondyloarthritis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Spondyloarthritis" returned 325 free, full-text research articles on human participants. First 3 results:

Axial Spondyloarthritis In Patients With Chronic Backache Using Assessment Of Spondyloarthritis International Society Criteria For Axial Spondyloarthritis.
 

Author(s): Tabe Rasool, Tahira Perveen Umer, Lubna Nazir, Shafique Rehman Arain, Kausar Phulpoto, Warda Afzal

Journal: J Ayub Med Coll Abbottabad. ;30(2):253-257.

 

Low back pain (LBP) is considered as one of the most frequent health problems which is responsible for forming a huge worldwide burden. This study was conducted with the aim to determine the frequency of axial-Spondyloarthropathy (axSpA) in patients presenting with chronic backache ...

Last Updated: 31 Dec 1969

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Influence of and Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population.
 

Author(s): Marco A Rocha Loures, Luciana C Macedo, Denise M Reis, Camila F Oliveira, Jean L Meneguetti, Gabriela F Martines, Janisleya S F Neves, Eliana de Souza, Ana M Sell, Jeane E L Visentainer

Journal:

 

Spondyloarthritis (SpA) represents a heterogeneous group of immune-mediated inflammatory diseases that have overlapping clinical features, genetic predisposition, and pathogenic mechanisms. Hence, we investigated, through a case-control study, whether single-nucleotide polymorphisms ...

Last Updated: 31 Dec 1969

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Clinical features of children with enthesitis-related juvenile idiopathic arthritis / juvenile spondyloarthritis followed in a French tertiary care pediatric rheumatology centre.
 

Author(s): Maxime Goirand, Sylvain Breton, Frédéric Chevallier, Ngoc-Phoi Duong, Florence Uettwiller, Isabelle Melki, Richard Mouy, Carine Wouters, Brigitte Bader-Meunier, Chantal Job-Deslandre, Pierre Quartier

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Childhood-onset spondyloarthropathies usually start with enthesitis and peripheral arthritis. However, axial disease may develop afterward. Patients are most often classified, following revised (Edmonton 2011) ILAR criteria, as enthesitis-related arthritis, psoriatic arthritis, or ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Spondyloarthritis" returned 76 free, full-text review articles on human participants. First 3 results:

Nature versus nurture in the spectrum of rheumatic diseases: Classification of spondyloarthritis as autoimmune or autoinflammatory.
 

Author(s): Elena Generali, Tanima Bose, Carlo Selmi, J Willem Voncken, Jan G M C Damoiseaux

Journal: Autoimmun Rev. 2018 Sep;17(9):935-941.

 

Spondyloarthritides (SpA) include inflammatory joint diseases with various clinical phenotypes that may also include the axial skeleton and/or entheses. SpA include psoriatic arthritis, reactive arthritis, enteropathic arthritis and ankylosing spondylitis; the latter is frequently ...

Last Updated: 31 Dec 1969

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One year in review 2017: spondyloarthritis.
 

Author(s): Riccardo Terenzi, Sara Monti, Giulia Tesei, Linda Carli

Journal: Clin. Exp. Rheumatol.. ;36(1):1-14.

 

The term spondyloarthritis (SpA) represents a condition characterised by a broad spectrum of clinical manifestations, laboratory abnormalities and imaging features; in particular, SpA is an inflammatory condition in which both peripheral and axial joints might be affected. The majority ...

Last Updated: 31 Dec 1969

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The use of the tyrosine kinase inhibitor Nilotinib in Spondyloarthritis: does targeting inflammatory pathways with a treatment lead to vascular toxicity?
 

Author(s): Loukman Omarjee, Vincent Jaquinandi, Guillaume Mahe

Journal:

 

Spondylarthritis (SpA) is an inflammatory rheumatic disease associated with increased incidence of major adverse cardiovascular events (MACEs). Recently, Paramarta et al. proposed the use of the tyrosine kinase inhibitor Nilotinib in Spondyloarthritis to target certain inflammatory ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 20 Apr 2018

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Last Updated: 1 Aug 2018

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Last Updated: 3 Jul 2018

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