Squamous cell carcinoma

Common Name(s)

Squamous cell carcinoma

Squamous cell carcinoma is a type of cancer that develops in a type of flat-shaped cell that lines the skin and other organs. The most common location where squamous cell carcinoma develops is the skin, usually in areas that are frequently exposed to sunlight. Although less common, squamous cell carcinoma can also grow on the lips, in the mouth, or in the lungs. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow (metastasis).

Squamous cell carcinoma most commonly occurs in adults between the ages of 40 and 60, although it can be found in all age groups. Factors that increase the risk of developing squamous cell carcinoma include prolonged exposure to ultraviolet (UV) light and fair skin. Having an organ transplant can also increase the risk of developing squamous cell carcinoma, as medications taken after surgery can decrease the body’s ability to protect itself from damage.

The most common symptoms of squamous cell carcinoma of the skin include scaly, red skin patches and unexplained bleeding in areas affected by tumor growth. Other signs include the formation of white ulcers in the mouth and sun-exposed areas. Diagnosis is usually made with a combination of a physical exam, imaging studies, blood tests, and other laboratory studies. Diagnosis may require a doctor to take a biopsy, or sample, of the tissue to look at under a microscope in order to determine if the cells are growing in an abnormal way.

Treatment for squamous cell carcinoma depends on many factors such as how large the cancer is and if it has spread to other areas of the body. If you or a family member has been diagnosed with squamous cell carcinoma, talk to your doctor about the most current treatment options. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Squamous cell carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Squamous cell carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Squamous cell carcinoma" returned 7102 free, full-text research articles on human participants. First 3 results:

Oral leukoplakia, a precancerous lesion of squamous cell carcinoma, in patients with long-term pegylated liposomal doxorubicin treatment.
 

Author(s): Hidetaka Nomura, Kimihiko Sakamoto, Takeru Sugihara, Shuhei Okamoto, Yoichi Aoki, Terumi Tanigawa, Maki Matoda, Kohei Omatsu, Hiroyuki Kanao, Kazuyoshi Kato, Kuniko Utsugi, Yuko Sugiyama, Nobuhiro Takeshima

Journal: Medicine (Baltimore). 2018 Feb;97(7):e9932.

 

Pegylated liposomal doxorubicin (PLD) has a good safety profile, but long-term use has been associated with development of squamous cell carcinoma of the tongue and oral cavity (SCCTO) in some patients. The study objective was to estimate the prevalence of oral leukoplakia, a known ...

Last Updated: 31 Dec 1969

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Endoscopic traversability in patients with locally advanced esophageal squamous cell carcinoma: Is it a significant prognostic factor?
 

Author(s): Hae Jin Shin, Hee Seok Moon, Sun Hyung Kang, Jae Kyu Sung, Hyun Yong Jeong, Seok Hyun Kim, Byung Seok Lee, Ju Seok Kim, Gee Young Yun

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9441.

 

The purpose of this study was to evaluate the prognostic impact of endoscopic traversability in patients with locally advanced esophageal squamous cell carcinoma.This retrospective study was based on medical records from a single tertiary medical center. The records of 317 patients ...

Last Updated: 31 Dec 1969

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The comparison of acute toxicity in 2 treatment courses: Three-weekly and weekly cisplatin treatment administered with radiotherapy in patients with head and neck squamous cell carcinoma.
 

Author(s): Jacek Mackiewicz, Agnieszka Rybarczyk-Kasiuchnicz, Izabela Łasińska, Małgorzata Mazur-Roszak, Daria Świniuch, Michał Michalak, Joanna Kaźmierska, Adam Studniarek, Łukasz Krokowicz, Tomasz Bajon

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9151.

 

The most appropriate cisplatin treatment schedule delivered with radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC) is unknown. The aim of this study was to compare the acute toxicity and its impact on the course of the treatment, administered cisplatin and ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Squamous cell carcinoma" returned 391 free, full-text review articles on human participants. First 3 results:

Intracranial squamous cell carcinoma arising in a cerebellopontine angle epidermoid cyst: A case report and literature review.
 

Author(s): Tae Hoon Roh, Yong Sook Park, Yong Gou Park, Se Hoon Kim, Jong Hee Chang

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9423.

 

Most of the intracranial epidermoid cysts are benign, but malignant lesions are occasionally reported. These lesions appear as squamous cell carcinoma and carry a dismal prognosis. Here, we report a case of a primary intracranial squamous cell carcinoma arising in a cerebellopontine ...

Last Updated: 31 Dec 1969

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The value of squamous cell carcinoma antigen (SCCa) to determine the lymph nodal metastasis in cervical cancer: A meta-analysis and literature review.
 

Author(s): Ziqi Zhou, Wenbo Li, Fuquan Zhang, Ke Hu

Journal:

 

The diagnostic power of CT or MRI on the lymph node status was limited. Supplement measurements were needed to assist the diagnosis of lymph node metastasis. The SCCa was reported to be close related to lymph node status. But currently the clinical value of serum SCCa measurement ...

Last Updated: 31 Dec 1969

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The Notch signaling pathway in head and neck squamous cell carcinoma: A meta-analysis.
 

Author(s): Yu-Yue Zhao, Guang-Tao Yu, Ting Xiao, Jian Hu

Journal: Adv Clin Exp Med. 2017 Aug;26(5):881-887.

 

The Notch signaling pathway has been associated with the regulation of self-renewal capacity, cell cycle exit, and survival. However, the relationship between the Notch signaling pathway and HNSCC remains controversial.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Alpha Radiation Emitters Device for the Treatment of Squamous Cell Carcinoma (DaRT)
 

Status: Not yet recruiting

Condition Summary: Skin Squamous Cell Carcinoma

 

Last Updated: 22 Nov 2017

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Alpha Radiation Emitters Device for the Treatment of Squamous Cell Carcinoma
 

Status: Recruiting

Condition Summary: Squamous Cell Carcinoma

 

Last Updated: 20 Aug 2017

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PEmbrolizumab Combined With Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck
 

Status: Not yet recruiting

Condition Summary: Squamous Cell Carcinoma of the Head and Neck; Squamous Cell Carcinoma

 

Last Updated: 27 Jun 2016

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