Stevens-Johnson syndrome

Common Name(s)

Stevens-Johnson syndrome, Stevens Johnson Syndrome

Stevens-Johnson Syndrome (SJS), also called erythema multiforme major, is a limited form of toxic epidermal necrolysis. This disorder affects the skin, mucous membranes and eyes. Stevens-Johnson syndrome occurs twice as often in men as women, and most cases appear in children and young adults under 30, although it can develop in people at any age.  It is an emergency medical condition that usually requires hospitalization. Treatment focuses on eliminating the underlying cause, controlling symptoms and minimizing complications.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Stevens-Johnson syndrome" for support, advocacy or research.

Stevens Johnson Syndrome Foundation

The SJS Foundation was founded to be a resource to SJS victims and their families. Our mission is provide support services, and compile and distribute valuable information about SJS to the public and medical professionals regarding treatments and therapies that prove beneficial to SJS sufferers. We work to promote public awareness about the signs of SJS so that a quick diagnosis can be made and the offending drug stopped as soon as possible.

Last Updated: 28 Apr 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Stevens-Johnson syndrome" for support, advocacy or research.

Stevens Johnson Syndrome Foundation

The SJS Foundation was founded to be a resource to SJS victims and their families. Our mission is provide support services, and compile and distribute valuable information about SJS to the public and medical professionals regarding treatments and therapies that prove beneficial to SJS sufferers. We work to promote public awareness about the signs of SJS so that a quick diagnosis can be made and the offending drug stopped as soon as possible.

http://www.sjsupport.org

Last Updated: 28 Apr 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Stevens-Johnson syndrome" returned 216 free, full-text research articles on human participants. First 3 results:

The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China.
 

Author(s): Shang-Chen Yang, Sindy Hu, Sheng-Zheng Zhang, Jin-Wen Huang, Jing Zhang, Chao Ji, Bo Cheng

Journal:

 

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case ...

Last Updated: 31 Dec 1969

Go To URL
Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals.
 

Author(s): Luana Bernardes Arantes, Carmélia Santiago Reis, Alice Garbi Novaes, Marta Rodrigues de Carvalho, Leila Bernarda Donato Göttems, Maria Rita Carvalho Garbi Novaes

Journal: An Bras Dermatol. ;92(5):661-667.

 

Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions.

Last Updated: 31 Dec 1969

Go To URL
Association of the HLA-B alleles with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in the Javanese and Sundanese population of Indonesia: the important role of the HLA-B75 serotype.
 

Author(s): Rika Yuliwulandari, Erna Kristin, Kinasih Prayuni, Qomariyah Sachrowardi, Franciscus D Suyatna, Sri Linuwih Menaldi, Nuanjun Wichukchinda, Surakameth Mahasirimongkol, Larisa H Cavallari

Journal: Pharmacogenomics. 2017 Dec;18(18):1643-1648.

 

Carbamazepine (CBZ) is a common cause of life-threatening cutaneous adverse drug reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Previous studies have reported a strong association between the HLA genotype and CBZ-induced SJS/TEN. We investigated ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Stevens-Johnson syndrome" returned 23 free, full-text review articles on human participants. First 3 results:

The use of cyclosporine for Stevens-Johnson syndrome-toxic epidermal necrolysis spectrum at the University of Louisville: A case series and literature review.
 

Author(s): Clayton D Conner, Emily McKenzie, Cindy E Owen, Jeffrey P Callen

Journal:

 

Cyclosporine therapy for Stevens-Johnson syndrome-toxic epidermal necrolysis (SJSTEN) was first reported in the literature by Renfro et al. in 1989. Herein we report an additional 4 cases of SJS-TEN treated with cyclosporine.

Last Updated: 31 Dec 1969

Go To URL
Incidence and Triggers of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in a Large Cancer Patient Cohort.
 

Author(s): Nancy K Gillis, J Kevin Hicks, Gillian C Bell, Ashley J Daly, Peter A Kanetsky, Howard L McLeod

Journal: J. Invest. Dermatol.. 2017 09;137(9):2021-2023.

 

Last Updated: 31 Dec 1969

Go To URL
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Concise Review with a Comprehensive Summary of Therapeutic Interventions Emphasizing Supportive Measures.
 

Author(s): Jeremy A Schneider, Philip R Cohen

Journal: Adv Ther. 2017 06;34(6):1235-1244.

 

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two of the most severe dermatologic conditions occurring in the inpatient setting. There is a lack of consensus regarding appropriate management of SJS and TEN.

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Cyclosporine and Etanercept in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
 

Status: Not yet recruiting

Condition Summary: Stevens-Johnson Syndrome; Toxic Epidermal Necrolyses

 

Last Updated: 28 Mar 2017

Go to URL
Outcomes in Stevens Johnsons Syndrome and Toxic Epidermal Necrolysis
 

Status: Not yet recruiting

Condition Summary: Stevens-Johnson Syndrome; Toxic Epidermal Necrolysis; Drug Reaction

 

Last Updated: 2 Jul 2018

Go to URL
G-CSF in the Treatment of Toxic Epidermal Necrolysis
 

Status: Recruiting

Condition Summary: Stevens - Johnson Syndrome

 

Last Updated: 28 Oct 2016

Go to URL