Stevens-Johnson syndrome

Common Name(s)

Stevens-Johnson syndrome, Stevens Johnson Syndrome

Stevens-Johnson Syndrome (SJS), also called erythema multiforme major, is a limited form of toxic epidermal necrolysis. This disorder affects the skin, mucous membranes and eyes. Stevens-Johnson syndrome occurs twice as often in men as women, and most cases appear in children and young adults under 30, although it can develop in people at any age.  It is an emergency medical condition that usually requires hospitalization. Treatment focuses on eliminating the underlying cause, controlling symptoms and minimizing complications.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Stevens-Johnson syndrome" for support, advocacy or research.

Stevens Johnson Syndrome Foundation

The SJS Foundation was founded to be a resource to SJS victims and their families. Our mission is provide support services, and compile and distribute valuable information about SJS to the public and medical professionals regarding treatments and therapies that prove beneficial to SJS sufferers. We work to promote public awareness about the signs of SJS so that a quick diagnosis can be made and the offending drug stopped as soon as possible.

Last Updated: 28 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Stevens-Johnson syndrome" for support, advocacy or research.

Stevens Johnson Syndrome Foundation

The SJS Foundation was founded to be a resource to SJS victims and their families. Our mission is provide support services, and compile and distribute valuable information about SJS to the public and medical professionals regarding treatments and therapies that prove beneficial to SJS sufferers. We work to promote public awareness about the signs of SJS so that a quick diagnosis can be made and the offending drug stopped as soon as possible.

http://www.sjsupport.org

Last Updated: 28 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Stevens-Johnson syndrome" returned 199 free, full-text research articles on human participants. First 3 results:

Stevens-Johnson Syndrome After Influenza Vaccine Injection.
 

Author(s): T Oda, Y Sawada, E Okada, T Yamaguchi, S Ohmori, S Haruyama, M Yoshioka, M Nakamura

Journal: J Investig Allergol Clin Immunol. ;27(4):274-275.

 

Last Updated: 21 Jul 2017

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Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Induced by Fexofenadine.
 

Author(s): S L Teo, A Santosa, P L Bigliardi

Journal: J Investig Allergol Clin Immunol. 2017 Jun;27(3):191-193.

 

Last Updated: 1 Jun 2017

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Comparison of the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year retrospective study.
 

Author(s): Loraine L W Chow, Kendrick C Shih, Johnny C Y Chan, Jimmy S M Lai, Alex L K Ng

Journal:

 

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening conditions that initially affect the skin and mucous membranes. The aim of this study was to compare the acute ocular manifestations between SJS and TEN.

Last Updated: 13 May 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Stevens-Johnson syndrome" returned 18 free, full-text review articles on human participants. First 3 results:

Guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis: An Indian perspective.
 

Author(s): Lalit Kumar Gupta, Abhay Mani Martin, Nidheesh Agarwal, Paschal D'Souza, Sudip Das, Rajesh Kumar, Sushil Pande, Nilay Kanti Das, Muthuvel Kumaresan, Piyush Kumar, Anubhav Garg, Saurabh Singh

Journal: Indian J Dermatol Venereol Leprol. ;82(6):603-625.

 

Stevens-Johnson syndrome and toxic epidermal necrolysis are severe, life-threatening mucocutaneous adverse drug reactions with a high morbidity and mortality that require immediate medical care. The various immunomodulatory treatments include systemic corticosteroids, cyclosporine, ...

Last Updated: 7 Oct 2016

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Stevens-Johnson syndrome and toxic epidermal necrolysis: a review.
 

Author(s): Anthony Wong, Andrey Augusto Malvestiti, Mariana de Figueiredo Silva Hafner

Journal: Rev Assoc Med Bras (1992). ;62(5):468-73.

 

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are uncommon, acute and potentially life-threatening adverse cutaneous drug reactions. These pathologies are considered a hypersensitivity reaction and can be triggered by drugs, infections and malignancies. The drugs ...

Last Updated: 23 Sep 2016

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[News in severe clinical adverse drug reactions: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)].
 

Author(s): Sylvia Aide Martínez-Cabriales, Minerva Gómez-Flores, Jorge Ocampo-Candiani

Journal: Gac Med Mex. ;151(6):777-87.

 

Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening conditions associated with significant morbidity and mortality. They are considered to be part of a spectrum of cutaneous drug reactions, differing only by their extent of skin detachment due to keratinocyte ...

Last Updated: 20 Nov 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Cyclosporine and Etanercept in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
 

Status: Not yet recruiting

Condition Summary: Stevens-Johnson Syndrome; Toxic Epidermal Necrolyses

 

Last Updated: 28 Mar 2017

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HLA-B*5801 Screening to Prevent Allopurinol-induced Severe Cutaneous Adverse Reaction
 

Status: Recruiting

Condition Summary: Stevens-Johnson Syndrome; Kidney Failure, Chronic

 

Last Updated: 7 Feb 2017

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Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet Transplantation
 

Status: Available

Condition Summary: Limbal Stem Cell Deficiency; Stevens-johnson Syndrome; Ocular Cicatricial Pemphigoid; Chemical Burn

 

Last Updated: 18 Apr 2016

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