Stiff person syndrome

Common Name(s)

Stiff person syndrome

Stiff person syndrome (SPS) is a rare neurological disorder with features of an autoimmune disease. Symptoms may include muscle stiffness in the trunk and limbs, and heightened sensitivity to noise, touch, and emotional distress, which can set off muscle spasms. Affected people may also have abnormal postures, such as being hunched over. SPS affects twice as many women as men. It is frequently associated with other autoimmune diseases such as diabetes, thyroiditis, vitiligo, and pernicious anemia. The exact causes of SPS is not known. Treatment may involve high-dose diazepam, anti-convulsants, or intravenous immunoglobulin (IVIG).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Stiff person syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Stiff person syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Stiff person syndrome" returned 40 free, full-text research articles on human participants. First 3 results:

Presynaptic neuromuscular transmission defect in the stiff person syndrome.
 

Author(s): Y L Lo, Y E Tan

Journal:

 

The stiff person syndrome (SPS) is a rare disorder characterized by muscular rigidity and stiffness.

Last Updated: 1 Dec 2016

Go To URL
Stiff person syndrome in South Asia.
 

Author(s): Thashi Chang, Bethan Lang, Angela Vincent

Journal:

 

Stiff person syndrome is a highly disabling, progressive autoimmune disorder of the central nervous system characterized by muscle rigidity and spasms. Stiff person syndrome is rare, but is believed to be under diagnosed with only 14 cases been reported among a 1.7 billion population ...

Last Updated: 19 Oct 2016

Go To URL
Anesthesia in a patient with Stiff Person Syndrome.
 

Author(s): Ozgur Yagan, Kadir Özyilmaz, Ahmet Özmaden, Özgür Sayin, Volkan Hanci

Journal: Braz J Anesthesiol. ;66(5):543-5.

 

Stiff Person Syndrome (SPS), typified by rigidity in muscles of the torso and extremities and painful episodic spasms, is a rare autoimmune-based neurological disease. Here we present the successful endotracheal intubation and application of TIVA without muscle relaxants on an SPS ...

Last Updated: 4 Sep 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Stiff person syndrome" returned 2 free, full-text review articles on human participants. First 3 results:

Autoimmune stiff person syndrome and related myelopathies: understanding of electrophysiological and immunological processes.
 

Author(s): Goran Rakocevic, Mary Kay Floeter

Journal: Muscle Nerve. 2012 May;45(5):623-34.

 

Stiff person syndrome (SPS) is a disabling autoimmune central nervous system disorder characterized by progressive muscle rigidity and gait impairment with superimposed painful spasms that involve axial and limb musculature, triggered by heightened sensitivity to external stimuli. ...

Last Updated: 13 Apr 2012

Go To URL
Stiff-person syndrome associated with cerebellar ataxia and high glutamic acid decarboxylase antibody titer.
 

Author(s): S Kono, H Miyajima, M Sugimoto, Y Suzuki, Y Takahashi, A Hishida

Journal: Intern. Med.. 2001 Sep;40(9):968-71.

 

Glutamic acid decarboxylase (GAD) is the main target of humoral autoimmunity in patients with insulin-dependent diabetes mellitus (IDDM) and stiff-person syndrome. We reviewed the case of a 46-year-old woman who had cerebellar ataxia before getting stiff-person syndrome and IDDM with ...

Last Updated: 2 Oct 2001

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Stem Cell Transplantation for Stiff Person Syndrome (SPS)
 

Status: Recruiting

Condition Summary: Stiff Person Syndrome

 

Last Updated: 17 Jul 2017

Go to URL