Sudden arrhythmic death syndrome

Common Name(s)

Sudden arrhythmic death syndrome, Sudden adult death syndrome, Sudden death syndrome, SADS

Sudden arrhythmic death syndrome (SADS) is a genetic condition that causes sudden death in young, otherwise healthy, people. It is caused by a change (mutation) in a person’s gene or DNA. This mutation creates an abnormality in the heart which changes the way the heart beats (heart arrhythmia). The heart will speed up/slow down to the point where it can no longer pump blood. Often the heart will go back to its normal rhythm, but sometimes it will stop completely causing death. There are six different types of SADS.

A ‘SADS death’ is always sudden and often without prior warning. Warning signs of SADS include fainting or seizure during exercise or excitement, consistent or unusual chest pain or shortness of breath during exercise especially swimming, sudden fainting or seizure preceded by a sensation of a racing heart, or waking from sleep suddenly with dizziness or vision disturbance. SADS occurs more often in people aged 5 – 35. About 4000 people under the age of 35 die each year of unexpected heart arrhythmias in the United States.

Since there are usually no symptoms of SADS, diagnosis may be made after death by ruling out other possible causes. However if there is a family history of unexplained death in people younger than age 35, your primary care doctor may advise you to see a cardiologist. A cardiologist will run tests to see if an abnormal heart rhythm can be detected with an EKG (ECG or electrocardiogram) at rest and possibly during exercise. You may be asked to wear a heart monitor so your heart rhythm can be detected for a longer period of time. Unfortunately even then not all those affected will have a change of rhythm during the monitoring period. If you or a family member has a family history of SADS or been diagnosed with SADS, talk with your cardiologist about the most current diagnosis and treatment options. Support groups are also a good source of information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sudden arrhythmic death syndrome" for support, advocacy or research.

SADS (Sudden Arrhythmia Death Syndromes) Foundation

Our mission is to save the lives of young people who are genetically predisposed to sudden death due to cardiac arrhythmia and to provide education and support to families and the medical community.

Last Updated: 23 Apr 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sudden arrhythmic death syndrome" for support, advocacy or research.

SADS (Sudden Arrhythmia Death Syndromes) Foundation

Our mission is to save the lives of young people who are genetically predisposed to sudden death due to cardiac arrhythmia and to provide education and support to families and the medical community.

http://www.StopSADS.org

Last Updated: 23 Apr 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Sudden arrhythmic death syndrome" returned 8 free, full-text research articles on human participants. First 3 results:

Utility of Post-Mortem Genetic Testing in Cases of Sudden Arrhythmic Death Syndrome.
 

Author(s): Najim Lahrouchi, Hariharan Raju, Elisabeth M Lodder, Efstathios Papatheodorou, James S Ware, Michael Papadakis, Rafik Tadros, Della Cole, Jonathan R Skinner, Jackie Crawford, Donald R Love, Chee J Pua, Bee Y Soh, Jaydutt D Bhalshankar, Risha Govind, Jacob Tfelt-Hansen, Bo G Winkel, Christian van der Werf, Yanushi D Wijeyeratne, Greg Mellor, Jan Till, Marta C Cohen, Maria Tome-Esteban, Sanjay Sharma, Arthur A M Wilde, Stuart A Cook, Connie R Bezzina, Mary N Sheppard, Elijah R Behr

Journal: J. Am. Coll. Cardiol.. 2017 May;69(17):2134-2145.

 

Sudden arrhythmic death syndrome (SADS) describes a sudden death with negative autopsy and toxicological analysis. Cardiac genetic disease is a likely etiology.

Last Updated: 28 Apr 2017

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The Prevalence and Significance of the Early Repolarization Pattern in Sudden Arrhythmic Death Syndrome Families.
 

Author(s): Greg Mellor, Christopher P Nelson, Claire Robb, Hariharan Raju, Yanushi Wijeyeratne, Christian Hengstenberg, Wibke Reinhard, Michael Papadakis, Sanjay Sharma, Nilesh J Samani, Elijah R Behr

Journal: Circ Arrhythm Electrophysiol. 2016 Jun;9(6):.

 

The early repolarization (ER) pattern is associated with sudden death and has been shown to be heritable. Its significance when identified in families affected by sudden arrhythmic death syndrome (SADS) remains unclear.

Last Updated: 3 Jun 2016

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Clinical characteristics and circumstances of death in the sudden arrhythmic death syndrome.
 

Author(s): Greg Mellor, Hariharan Raju, Sofia V de Noronha, Michael Papadakis, Sanjay Sharma, Elijah R Behr, Mary N Sheppard

Journal: Circ Arrhythm Electrophysiol. 2014 Dec;7(6):1078-83.

 

Sudden cardiac death (SCD) is a devastating event in the young. Referral to a specialist cardiac pathologist is recommended. Age, sex, and circumstances of death may reflect underlying diagnoses. We aim to describe the demographics of victims and circumstances surrounding sudden cardiac ...

Last Updated: 17 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Sudden arrhythmic death syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.