Syndactyly

Common Name(s)

Syndactyly

Syndactyly describes when two or more fingers or toes (digits) fused or joined together at birth (congenital). The fused digits look like they are webbed. Simple syndactyly occurs when the digits are only fused with skin and complex syndactyly occurs when the bones in the digits are fused. Complete syndactyly occurs when the digits are fused all the way to the tip and incomplete occurs when only a part of the digits are fused. While a baby is developing during a pregnancy, the fingers and toes start off as fused together. Around the 16th week of development, these fused digits begin to separate. However, in some babies, the separation does not happen, causing the fingers or toes to remain fused.

Syndactyly occurs in 1 out of every 2,5000 births. This condition generally affects Caucasians more so than African or Asian individuals and typically affects boys more often than girls. About half of the time the condition will affect both hands. Syndactyly can be seen as the only abnormality a baby has at birth (isolated syndactyly) or it can be seen as part of many abnormalities, known as a genetic condition or syndrome. The only treatment for syndactyly is surgery. If your child has syndactyly, speak with your doctor about the most current treatment options. Support groups can provide additional information and connect you with other families affected by syndactyly.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Syndactyly" for support, advocacy or research.

National Foundation for Syndactyly

The National Foundation for Syndactyly Research, Support, and Education is a charitable, tax-exempt, 501(c)(3) organization organized to fund research, support, and education. The foundation serves as a resource to connect families touched by Syndactyly and other related hand abnormalities with other families, facilities for treatment, and board certified hand physicians who specialize in Syndactyly treatment. We provide research grants to investigate the causes and best practices in treatment as funding permits. - See more at: http://nfsus.org

Last Updated: 8 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Syndactyly" for support, advocacy or research.

National Foundation for Syndactyly

The National Foundation for Syndactyly Research, Support, and Education is a charitable, tax-exempt, 501(c)(3) organization organized to fund research, support, and education. The foundation serves as a resource to connect families touched by Syndactyly and other related hand abnormalities with other families, facilities for treatment, and board certified hand physicians who specialize in Syndactyly treatment. We provide research grants to investigate the causes and best practices in treatment as funding permits. - See more at: http://nfsus.org

http://nfsus.org

Last Updated: 8 Jul 2015

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General Support Organizations

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General Resources

Facility and Physician Support

NFS provides informational brochures to Children's' Hospitals, Physicians, and Therapy Centers to help afflicted families connect to NFS Family Support Services.

Updated 7 Jul 2015

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Family Support

NFS serves as a resource to families afflicted by Syndactyly or any related congenial hand or feet birth defects.

Updated 7 Jul 2015

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Research Grants

NFS provides research grants as funds are available. Grants are submitted by July annually and if approved, are awarded each September. Grant are only available for qualified research initiatives and are not available for administrative support.

Updated 7 Jul 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Syndactyly" returned 51 free, full-text research articles on human participants. First 3 results:

The use of a dorsal double-wing flap without skin grafts for congenital syndactyly treatment: A STROBE compliant study.
 

Author(s): Yanzhao Dong, Yisheng Wang

Journal: Medicine (Baltimore). 2017 Jul;96(30):e7639.

 

Numerous techniques have been developed that use various flaps to treat syndactyly. Skin grafts have often been used to cover remaining surgical defects. The long-term aim of surgery is to find new methods of separating the digits without using skin grafts. This paper describes a ...

Last Updated: 26 Jul 2017

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Congenital cutis marmorata telangiectatica and syndactyly in a preterm: case report.
 

Author(s): Ozkan Ilhan, Esra A Ozer, Senem A Ozdemir, Sinem Akbay, Seyma Memur, Berat Kanar, Melek Akar, Sumer Sutcuoglu, Mustafa M Tatli

Journal: Arch Argent Pediatr. 2016 Apr;114(2):e111-3.

 

Cutis marmorata telangiectatica congenita (CMTC) is a rare, commonly benign, congenital, localized or generalized vascular anomaly of unknown aetiology. It is characterized by persistent cutis marmorata, telangiectasia and phlebectasia. Extracutaneous findings may be associated with ...

Last Updated: 15 Apr 2016

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Syndactyly in a novel Fras1(rdf) mutant results from interruption of signals for interdigital apoptosis.
 

Author(s): Elizabeth A Hines, Jamie M Verheyden, Amber J Lashua, Sarah C Larson, Kelsey Branchfield, Eric T Domyan, Juan Gao, Julie F Harvey, John C Herriges, Linghan Hu, David J Mcculley, Kurt Throckmorton, Shigetoshi Yokoyama, Akihiro Ikeda, Guoliang Xu, Xin Sun

Journal: Dev. Dyn.. 2016 Apr;245(4):497-507.

 

Fras1 encodes an extracellular matrix protein that is critical for the establishment of the epidermal basement membrane during gestation. In humans, mutations in FRAS1 cause Fraser Syndrome (FS), a pleiotropic condition with many clinical presentations such as limb, eye, kidney, and ...

Last Updated: 22 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Syndactyly" returned 6 free, full-text review articles on human participants. First 3 results:

Iloprost administration in acrodermatitis of Hallopeau complicated by acquired toes syndactyly: a case report and review of the literature.
 

Author(s): F Segreto, D Tosi, G F Marangi, A L Pendolino, S Santoro, P Gigliofiorito, P Persichetti

Journal: Eur Rev Med Pharmacol Sci. 2015 Aug;19(16):2945-8.

 

Acrodermatitis Continua of Hallopeau (ACH) is a variant of pustular psoriasis often very difficult to treat. Secondary syndactyly, also called "pseudosyndactyly", is rare and can be a complication of burns, dystrophic epidermolysis bullosa or trauma. If left untreated, joint complications ...

Last Updated: 15 Sep 2015

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Treatment of congenital syndactyly of the fingers.
 

Author(s): Hebe Désirée Kvernmo, Jan-Ragnar Haugstvedt

Journal: Tidsskr. Nor. Laegeforen.. 2013 Aug;133(15):1591-5.

 

Syndactyly or webbed fingers is one of the most common congenital malformations of the upper extremities, but it comprises few new cases annually. The purpose of treatment is to enhance hand function.

Last Updated: 23 Aug 2013

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Syndactyly: phenotypes, genetics and current classification.
 

Author(s): Sajid Malik

Journal: Eur. J. Hum. Genet.. 2012 Aug;20(8):817-24.

 

Syndactyly is one of the most common hereditary limb malformations depicting the fusion of certain fingers and/or toes. It may occur as an isolated entity or a component of more than 300 syndromic anomalies. Syndactylies exhibit great inter- and intra-familial clinical variability. ...

Last Updated: 19 Jul 2012

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 11 Aug 2017

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