Synovial sarcoma

Common Name(s)

Synovial sarcoma

Synovial sarcoma is rare and aggressive soft tissue sarcoma that appears as deep, painless, slowly growing masses. Most frequently the tumor affects the legs, especially the knees, and the arms. Less frequently, this disease develops in the trunk, head and neck region, or the abdomen. Although synovial sarcoma does not have a clearly defined cause, genetic factors are believed to influence the development of this disease. Cells in these tumors are usually characterized by the presence of a translocation involving chromosomes X and 18. This translocation is specific to synovial sarcoma and is often used to diagnose this cancer. Although this condition generally affects adults, about 30% of reported cases occur in children and adolescents.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Synovial sarcoma" for support, advocacy or research.

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Ben's Friends

Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.

Last Updated: 11 Jul 2016

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Synovial sarcoma" for support, advocacy or research.

Logo
Ben's Friends

Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.

http://www.bensfriends.org

Last Updated: 11 Jul 2016

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

View Details
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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Synovial sarcoma" returned 319 free, full-text research articles on human participants. First 3 results:

Transforming growth factor-β1 signaling promotes epithelial-mesenchymal transition-like phenomena, cell motility, and cell invasion in synovial sarcoma cells.
 

Author(s): Yan Qi, Ning Wang, Yonglai He, Jun Zhang, Hong Zou, Wenjie Zhang, Wenyi Gu, Yalan Huang, Xiaojuan Lian, Jianming Hu, Jin Zhao, Xiaobin Cui, Lijuan Pang, Feng Li

Journal:

 

The epithelial-to-mesenchymal transition (EMT) and the reverse process (the mesenchymal-to-epithelial transition [MET]) have been shown to be associated with tumor cell invasion and metastasis in different carcinomas. The EMT and MET have recently been shown to play a key role in ...

Last Updated: 22 Aug 2017

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[Primary pharynx synovial sarcoma: a case report].
 

Author(s): Cui Qingying, Zhang Youmei, Fu Shuai, Zhang Changbin, Li Ming

Journal: Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Apr;35(2):221-222.

 

A case of primary pharynx synovial sarcoma was reported in this paper. A 15-year-old male patient experienced painless pharyngeal swelling that gradually proliferated for 1 month. Special examination showed an 8 cm × 4 cm × 3 cm tumor located in the left pharynx and the supratonsillar ...

Last Updated: 6 Jul 2017

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Influence of neoadjuvant chemotherapy on prognosis of patients with synovial sarcoma.
 

Author(s): Yanan Wu, Wenzhi Bi, Gang Han, Jinpeng Jia, Meng Xu

Journal:

 

This study aimed to explore the clinical efficacy of neoadjuvant chemotherapy combined with surgery in primary synovial sarcoma of the limbs and trunk through retrospective analysis of patients with primary synovial sarcoma of the limbs and trunk treated by this treatment in our hospital.

Last Updated: 12 May 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Synovial sarcoma" returned 32 free, full-text review articles on human participants. First 3 results:

Current status of engineered T-cell therapy for synovial sarcoma.
 

Author(s): Matthew Dallos, William D Tap, Sandra P D'Angelo

Journal: Immunotherapy. 2016 Sep;8(9):1073-80.

 

Synovial sarcoma is a rare soft tissue sarcoma characterized by a t(X;18) translocation, which results in a SYT-SSX gene fusion. In the metastatic setting, chemotherapy has limited, durable efficacy prompting the necessity for new therapeutic modalities. One emerging new strategy ...

Last Updated: 3 Aug 2016

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Primary synovial sarcoma of the abdominal wall: a case report and literature review.
 

Author(s): Supika Kritsaneepaiboon, Surasak Sangkhathat, Winyou Mitarnun

Journal:

 

Synovial sarcoma (SS) is the fourth most common type of soft tissue sarcoma, following malignant fibrous histiocytoma, liposarcoma, and rhabdomyosarcoma. It usually occurs in the extremities near the large joints of middle-aged patients. We describe a case of synovial sarcoma of the ...

Last Updated: 2 Dec 2015

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Synovial sarcoma of the heart: A case report and literature review.
 

Author(s): Prasad Eswaran, Premkumar Devadoss, Lakshmi S Narasimhan, Kalaichelvi Kannan

Journal: J Cancer Res Ther. ;11(3):659.

 

Primary cardiac tumors are of rare presentation. We present a case of synovial sarcoma of the right atrium treated in our institution. An initial diagnosis of right atrial myxoma was made based on clinico-radiological features. Intra-operatively, an irregular mass was found. Histopathologically, ...

Last Updated: 13 Oct 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 12 Oct 2017

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Last Updated: 13 Oct 2017

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DHEA in Synovial Sarcoma Patients
 

Status: Recruiting

Condition Summary: Synovial Sarcoma; Sarcoma, Synovial

 

Last Updated: 31 Aug 2017

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