SAPHO syndrome

Common Name(s)

SAPHO syndrome, Synovitis acne pustulosis hyperostosis osteitis

SAPHO syndrome involves any combination of: Synovitis (inflammation of the joints), Acne, Pustulosis (thick yellow blisters containing pus) often on the palms and soles, Hyperostosis (increase in bone substance) and Osteitis (inflammation of the bones). The cause of SAPHO syndrome is unknown and treatment is focused on managing symptoms.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "SAPHO syndrome" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

Last Updated: 24 Jul 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "SAPHO syndrome" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

http://www.autoinflammatory.org

Last Updated: 24 Jul 2015

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General Support Organizations

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General Resources

Healthier Ever After (injection tips book & program)

This child-friendly book is for patients and their families to learn how to manage their injectable medications, and has a program to help children to discuss and make a plan of care, and goals with rewards to chart on a reusable white board page.

Updated 6 May 2015

Open Doc
 
 
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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "SAPHO syndrome" returned 52 free, full-text research articles on human participants. First 3 results:

The coexistence of SAPHO syndrome and rheumatoid arthritis: A case report.
 

Author(s): Wenrui Xu, Chen Li, Weihong Zhang

Journal: Medicine (Baltimore). 2017 Jan;96(1):e5724.

 

SAPHO (Synovitis-Acne-Pustulosis-Hyperstosis-Osteitis) syndrome is a rare disease featured by its dermatological and osteoarthritic disorders, the latter of which mainly affecting the anterior chest wall, spine, and sacroiliac joint. However, rheumatoid arthritis (RA) is a chronic ...

Last Updated: 10 Jan 2017

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Serum Interleukin-18, Fetuin-A, Soluble Intercellular Adhesion Molecule-1, and Endothelin-1 in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome.
 

Author(s): Hanna Przepiera-Będzak, Katarzyna Fischer, Marek Brzosko

Journal:

 

To examine serum interleukin 18 (IL-18), fetuin-A, soluble intercellular adhesion molecule-1 (sICAM-1), and endothelin-1 (ET-1) levels in ankylosing spondylitis (AS), psoriatic arthritis (PsA), and Synovitis Acne Pustulosis Hyperostosis Osteitis syndrome (SAPHO). We studied 81 AS, ...

Last Updated: 16 Aug 2016

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A case report of severely damaged hip joint caused by SAPHO syndrome treated with 2-stage total hip arthroplasty.
 

Author(s): Ingwon Yeo, Hoon-Suk Cha, Young Cheol Yoon, Youn-Soo Park, Seung-Jae Lim

Journal: Medicine (Baltimore). 2016 Jul;95(27):e4168.

 

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is an increasingly recognized entity. The hip joint is known as a less frequently affected site in SAPHO syndrome, and there has been limited reports about hip joint diseases caused by SAPHO syndrome, and as ...

Last Updated: 12 Jul 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "SAPHO syndrome" returned 5 free, full-text review articles on human participants. First 3 results:

Thrombotic manifestations in SAPHO syndrome. Review of the literature.
 

Author(s): Tatiana Elizabeth Carranco-Medina, Cristina Hidalgo-Calleja, Ismael Calero-Paniagua, María Dolores Sánchez-González, Alba Quesada-Moreno, Ricardo Usategui-Martín, Laura Pérez-Garrido, Susana Gómez-Castro, Carlos Alberto Montilla-Morales, Olga Martínez-González, Javier Del Pino-Montes

Journal: Reumatol Clin. ;11(2):108-11.

 

SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a cluster of osteo-cutaneous manifestations that can lead to serious complications such as thrombosis of the subclavian vein or superior vena cava, mainly in patients with significant inflammatory involvement ...

Last Updated: 2 Mar 2015

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The SAPHO syndrome.
 

Author(s): Minhchau Thi Nguyen, Andrea Borchers, Carlo Selmi, Stanley M Naguwa, Gurtej Cheema, M Eric Gershwin

Journal: Semin. Arthritis Rheum.. 2012 Dec;42(3):254-65.

 

To review the epidemiology, presentation, diagnosis, treatment, pathogenesis, and genetics of the syndrome known under the acronym of SAPHO for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis to heighten awareness of this entity.

Last Updated: 16 Nov 2012

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SAPHO syndrome--a pictorial assay.
 

Author(s): Lokesh Khanna, Georges Y El-Khoury

Journal: Iowa Orthop J. 2012 ;32():189-95.

 

SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a distinct clinical entity representing involvement of the musculoskeletal and dermatologic systems. It is well known to rheumatologists because of characteristic skin manifestations and polyarthropathy. However, ...

Last Updated: 11 Apr 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Chronic Non-bacterial Osteomyelitis Treated With Pamidronate
 

Status: Recruiting

Condition Summary: Immune System Disease; Musculoskeletal Disease

 

Last Updated: 15 Nov 2016

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