SAPHO syndrome

Common Name(s)

SAPHO syndrome, Synovitis acne pustulosis hyperostosis osteitis

SAPHO syndrome involves any combination of: Synovitis (inflammation of the joints), Acne, Pustulosis (thick yellow blisters containing pus) often on the palms and soles, Hyperostosis (increase in bone substance) and Osteitis (inflammation of the bones). The cause of SAPHO syndrome is unknown and treatment is focused on managing symptoms.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "SAPHO syndrome" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

Last Updated: 24 Jul 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "SAPHO syndrome" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

http://www.autoinflammatory.org

Last Updated: 24 Jul 2015

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General Support Organizations

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General Resources

Healthier Ever After (injection tips book & program)

This child-friendly book is for patients and their families to learn how to manage their injectable medications, and has a program to help children to discuss and make a plan of care, and goals with rewards to chart on a reusable white board page.

Updated 6 May 2015

Open Doc
 
 
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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "SAPHO syndrome" returned 63 free, full-text research articles on human participants. First 3 results:

Diagnostic value of ultrasonography in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome: A case report.
 

Author(s): Tomoyuki Asano, Makiko Yashiro Furuya, Yuya Fujita, Naoki Matsuoka, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Aki Honda, Kiyoshi Migita

Journal: Medicine (Baltimore). 2018 Oct;97(41):e12725.

 

Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is a rare condition that affects the skin, bones, and joints. Diagnosis of SAPHO syndrome is established based on clinical manifestations and imaging features on radiography or magnetic resonance imaging.

Last Updated: 31 Dec 1969

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Case report: successful treatment of refractory SAPHO syndrome with the JAK inhibitor tofacitinib.
 

Author(s): Qiao Yang, Yumo Zhao, Chen Li, Yaping Luo, Weixin Hao, Wen Zhang

Journal: Medicine (Baltimore). 2018 Jun;97(25):e11149.

 

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is an autoinflammatory disorder without standardized treatment. Janus kinase (JAK) inhibitors can block a range of cytokines and might possess significant anti-inflammatory activity. Here, we report the first ...

Last Updated: 31 Dec 1969

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F-18 FDG PET/CT in 26 patients with SAPHO syndrome: a new vision of clinical and bone scintigraphy correlation.
 

Author(s): Xiaochuan Sun, Chen Li, Yihan Cao, Ximin Shi, Li Li, Weihong Zhang, Xia Wu, Nan Wu, Hongli Jing, Wen Zhang

Journal:

 

Whole-body bone scintigraphy (WBBS) and MRI are widely used in assessment of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. However, the value of F-18 fluorodeoxyglucose-positron emission tomography/computed tomography (F-FDG PET/CT) in SAPHO ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "SAPHO syndrome" returned 6 free, full-text review articles on human participants. First 3 results:

SAPHO Syndrome: Current Developments and Approaches to Clinical Treatment.
 

Author(s): Davide Firinu, Vanessa Garcia-Larsen, Paolo Emilio Manconi, Stefano R Del Giacco

Journal: Curr Rheumatol Rep. 2016 Jun;18(6):35.

 

SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare autoimmune disease which, due to its clinical presentation and symptoms, is often misdiagnosed and unrecognized. Its main features are prominent inflammatory cutaneous and articular manifestations. ...

Last Updated: 31 Dec 1969

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Thrombotic manifestations in SAPHO syndrome. Review of the literature.
 

Author(s): Tatiana Elizabeth Carranco-Medina, Cristina Hidalgo-Calleja, Ismael Calero-Paniagua, María Dolores Sánchez-González, Alba Quesada-Moreno, Ricardo Usategui-Martín, Laura Pérez-Garrido, Susana Gómez-Castro, Carlos Alberto Montilla-Morales, Olga Martínez-González, Javier Del Pino-Montes

Journal: Reumatol Clin. ;11(2):108-11.

 

SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a cluster of osteo-cutaneous manifestations that can lead to serious complications such as thrombosis of the subclavian vein or superior vena cava, mainly in patients with significant inflammatory involvement ...

Last Updated: 31 Dec 1969

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The SAPHO syndrome.
 

Author(s): Minhchau Thi Nguyen, Andrea Borchers, Carlo Selmi, Stanley M Naguwa, Gurtej Cheema, M Eric Gershwin

Journal: Semin. Arthritis Rheum.. 2012 Dec;42(3):254-65.

 

To review the epidemiology, presentation, diagnosis, treatment, pathogenesis, and genetics of the syndrome known under the acronym of SAPHO for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis to heighten awareness of this entity.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.