Syphilis

Common Name(s)

Syphilis

Syphilis is a bacterial infection most often spread by sexual contact. It begins as a painless sore typically on the genitals, rectum or mouth. It can also be transmitted or passed to another person by kissing an affected individual with an open or active sore or lesion. Syphilis occurs in stages but the symptoms vary and don't always occur in the same order. The sore is often in a hidden area so may not be noticed and usually heals itself within 6 weeks, this stage is called primary syphilis. Secondary syphilis occurs within a few weeks after the original sore heals. Symptoms often include a whole body rash which covers the palms of hands and soles of feet as well. It is usually not itchy and sometimes fever, sore throat and muscle aches occur as well. These symptoms may heal within a few weeks or come and go for up to a year. If a person is not treated for syphilis, the condition then goes into a latent (or hidden) phase which can last for many years. At this point, symptoms may never return or in 15-30% of untreated people, the disease will progress to the late stage (or tertiary stage). The disease can then damage the brain, heart, nerves, eyes, liver, bones and joints. Risk factors include having multiple sexual partners, being HIV positive, and recreational drug use. Syphilis can be detected through a blood test, fluid sample from the sore itself, or by spinal tap which takes a sample of fluid from the spinal cord. When diagnosed in the early stages, syphilis can easily be cured with the antibiotic, penicillin. As the disease progresses, other treatments may be needed. Since it is possible to be infected with syphilis and not know it, all pregnant women should be tested for the disease since it can be passed to an unborn child and can cause serious, even life-threatening problems at birth (please also visit: Congenital syphilis).

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Syphilis" for support, advocacy or research.

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The STD Project

Established in April of 2012 during STD Awareness Month, The STD Project is a multi-award-winning independent website and progressive movement eradicating STD stigma by facilitating and encouraging awareness, education, and acceptance through story-telling and resource recommendations. We are taking steps toward modern-day sexual health and prevention by advocating for conscientious and informed decisions.

Last Updated: 11 Jul 2016

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Syphilis" for support, advocacy or research.

Logo
The STD Project

Established in April of 2012 during STD Awareness Month, The STD Project is a multi-award-winning independent website and progressive movement eradicating STD stigma by facilitating and encouraging awareness, education, and acceptance through story-telling and resource recommendations. We are taking steps toward modern-day sexual health and prevention by advocating for conscientious and informed decisions.

http://www.thestdproject.com/

Last Updated: 11 Jul 2016

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Syphilis" returned 1832 free, full-text research articles on human participants. First 3 results:

Prevalence of syphilis and HIV infection during pregnancy in incarcerated women and the incidence of congenital syphilis in births in prison in Brazil.
 

Author(s): Rosa Maria Soares Madeira Domingues, Maria do Carmo Leal, Ana Paula Esteves Pereira, Barbara Ayres, Alexandra Roma Sánchez, Bernard Larouzé

Journal:

 

This study aimed to estimate the prevalence of syphilis and HIV infection during pregnancy, the mother to child transmission of syphilis and the incidence of congenital syphilis in incarcerated women in Brazil; to compare these rates to those observed in pregnant women outside of ...

Last Updated: 31 Dec 1969

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Syphilis and HIV infections among pregnant women attending antenatal clinics in Republic of Congo.
 

Author(s): Roch Fabien Niama, Nadia Claricelle Loukabou Bongolo, Edith Sophie Bayonne Kombo, Ruth Yengo, Pembe Issamou Mayengue, Etoka-Beka Mandingha Kosso, Igor Louzolo, Lucette Macosso, Ghislain Dzeret, Angélie Serge Patrick Dzabatou Babeaux, Marie-Francke Puruehnce, Henri Joseph Parra

Journal:

 

HIV and syphilis during pregnancy remain a public health concern especially in developing countries. Pregnant women attending antenatal clinics sites for the first time between September and December 2011 and who accepted to participate in the study were enrolled. The objective was ...

Last Updated: 31 Dec 1969

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Comparison of seropositivity of human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and syphilis among Hospital Cornea Retrieval Programme-Donors versus voluntary cornea donors at a large eye bank in Eastern India.
 

Author(s): Soham Basak, Samar K Basak, Bani Biswas

Journal: Indian J Ophthalmol. 2017 Nov;65(11):1138-1142.

 

To compare the serology profile of donors from Hospital Cornea Retrieval Programme-donors (HCRP-D) and voluntary cornea donors (VC-D) from a large eye bank in Eastern India.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Syphilis" returned 95 free, full-text review articles on human participants. First 3 results:

Syphilis of the lumbar spine: A case report and review of the literature.
 

Author(s): Ruofeng Yin, Liping Wang, Tinglong Zhang, Baolin Zhao

Journal: Medicine (Baltimore). 2017 Dec;96(50):e9098.

 

Tertiary syphilis can manifest as gummatous disease, but gumma of the spine has been extremely rarely reported.

Last Updated: 31 Dec 1969

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Comparison of efficacy of treatments for early syphilis: A systematic review and network meta-analysis of randomized controlled trials and observational studies.
 

Author(s): Hong-Ye Liu, Yan Han, Xiang-Sheng Chen, Li Bai, Shu-Ping Guo, Li Li, Peng Wu, Yue-Ping Yin

Journal:

 

Parenteral penicillin is the first-line regimen for treating syphilis, but unsuitable for some patients due to penicillin allergy and lacking health resources. Unfortunately, the efficacy of penicillin alternatives remains poorly understood. This study aimed to assess the efficacy ...

Last Updated: 31 Dec 1969

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A double-edged sword: does highly active antiretroviral therapy contribute to syphilis incidence by impairing immunity to?
 

Author(s): Michael L Rekart, Wilfred Ndifon, Robert C Brunham, Jonathan Dushoff, Sang Woo Park, Sanjana Rawat, Caroline E Cameron

Journal: Sex Transm Infect. 2017 08;93(5):374-378.

 

Recently, the world has experienced a rapidly escalating outbreak of infectious syphilis primarily affecting men who have sex with men (MSM); many are taking highly active antiretroviral therapy (HAART) for HIV-1 infection. The prevailing hypothesis is that HAART availability and ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lumbar Puncture and Syphilis Outcome
 

Status: Recruiting

Condition Summary: Syphilis

 

Last Updated: 12 Dec 2017

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Last Updated: 18 Sep 2017

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Last Updated: 4 Aug 2016

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