Syphilis

Common Name(s)

Syphilis

Syphilis is a bacterial infection most often spread by sexual contact. It begins as a painless sore typically on the genitals, rectum or mouth. It can also be transmitted or passed to another person by kissing an affected individual with an open or active sore or lesion. Syphilis occurs in stages but the symptoms vary and don't always occur in the same order. The sore is often in a hidden area so may not be noticed and usually heals itself within 6 weeks, this stage is called primary syphilis. Secondary syphilis occurs within a few weeks after the original sore heals. Symptoms often include a whole body rash which covers the palms of hands and soles of feet as well. It is usually not itchy and sometimes fever, sore throat and muscle aches occur as well. These symptoms may heal within a few weeks or come and go for up to a year. If a person is not treated for syphilis, the condition then goes into a latent (or hidden) phase which can last for many years. At this point, symptoms may never return or in 15-30% of untreated people, the disease will progress to the late stage (or tertiary stage). The disease can then damage the brain, heart, nerves, eyes, liver, bones and joints. Risk factors include having multiple sexual partners, being HIV positive, and recreational drug use. Syphilis can be detected through a blood test, fluid sample from the sore itself, or by spinal tap which takes a sample of fluid from the spinal cord. When diagnosed in the early stages, syphilis can easily be cured with the antibiotic, penicillin. As the disease progresses, other treatments may be needed. Since it is possible to be infected with syphilis and not know it, all pregnant women should be tested for the disease since it can be passed to an unborn child and can cause serious, even life-threatening problems at birth (please also visit: Congenital syphilis).

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Syphilis" for support, advocacy or research.

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The STD Project

Established in April of 2012 during STD Awareness Month, The STD Project is a multi-award-winning independent website and progressive movement eradicating STD stigma by facilitating and encouraging awareness, education, and acceptance through story-telling and resource recommendations. We are taking steps toward modern-day sexual health and prevention by advocating for conscientious and informed decisions.

Last Updated: 11 Jul 2016

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Syphilis" for support, advocacy or research.

Logo
The STD Project

Established in April of 2012 during STD Awareness Month, The STD Project is a multi-award-winning independent website and progressive movement eradicating STD stigma by facilitating and encouraging awareness, education, and acceptance through story-telling and resource recommendations. We are taking steps toward modern-day sexual health and prevention by advocating for conscientious and informed decisions.

http://www.thestdproject.com/

Last Updated: 11 Jul 2016

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Syphilis" returned 1871 free, full-text research articles on human participants. First 3 results:

HIV, syphilis and behavioral risk factors among men who have sex with men in a drug-using area of southwestern China: Results of 3 cross-sectional surveys from 2013 to 2015.
 

Author(s): Lan Guanghua, Chen Yi, Tang Shuai, Shen Zhiyong, Tang Zhenzhu, Ruan Yuhua, Mohammed Adnan Yousuf, Fan Wensheng

Journal: Medicine (Baltimore). 2018 Apr;97(16):e0404.

 

To assess human immunodeficiency virus (HIV), syphilis, and behavioral risk factors among men who have sex with men (MSM) in southwestern China, where HIV started as a drug-driven epidemic, and shifted to mainly heterosexual transmission.These cross-sectional studies were conducted ...

Last Updated: 31 Dec 1969

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Corymbiform syphilis associated with three other sexually transmitted infections.
 

Author(s): John Verrinder Veasey, Lyvia Almeida Nascimento Salem, Felipe Henrique Yazawa Santos

Journal: An Bras Dermatol. ;93(1):129-132.

 

Secondary syphilis can have different clinical presentations, with corymbiform rash as its rarest manifestation. The disease is characterized by a central papule surrounded by smaller ones. We report the case of a man who has sex with man with corymbiform syphilis. The patient was ...

Last Updated: 31 Dec 1969

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Increasing incidence of syphilis among patients engaged in HIV care in Alberta, Canada: a retrospective clinic-based cohort study.
 

Author(s): Raynell Lang, Ron Read, Hartmut B Krentz, Soheil Ramazani, Mingkai Peng, Jennifer Gratrix, M John Gill

Journal:

 

Syphilis is a global health concern disproportionately affecting HIV-infected populations. In Alberta, Canada, the incidence of syphilis in the general population has recently doubled with 25% of these infections occurring in HIV-infected patients. The Southern Alberta HIV Clinic ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Syphilis" returned 100 free, full-text review articles on human participants. First 3 results:

Syphilis of the lumbar spine: A case report and review of the literature.
 

Author(s): Ruofeng Yin, Liping Wang, Tinglong Zhang, Baolin Zhao

Journal: Medicine (Baltimore). 2017 Dec;96(50):e9098.

 

Tertiary syphilis can manifest as gummatous disease, but gumma of the spine has been extremely rarely reported.

Last Updated: 31 Dec 1969

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A systematic review and meta-analysis of studies evaluating the performance and operational characteristics of dual point-of-care tests for HIV and syphilis.
 

Author(s): Harriet D Gliddon, Rosanna W Peeling, Mary L Kamb, Igor Toskin, Teodora E Wi, Melanie M Taylor

Journal: Sex Transm Infect. 2017 12;93(S4):S3-S15.

 

Mother-to-child transmission (MTCT) of syphilis and HIV continue to be important yet preventable causes of perinatal and infant morbidity and mortality.

Last Updated: 31 Dec 1969

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Comparison of efficacy of treatments for early syphilis: A systematic review and network meta-analysis of randomized controlled trials and observational studies.
 

Author(s): Hong-Ye Liu, Yan Han, Xiang-Sheng Chen, Li Bai, Shu-Ping Guo, Li Li, Peng Wu, Yue-Ping Yin

Journal:

 

Parenteral penicillin is the first-line regimen for treating syphilis, but unsuitable for some patients due to penicillin allergy and lacking health resources. Unfortunately, the efficacy of penicillin alternatives remains poorly understood. This study aimed to assess the efficacy ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lumbar Puncture and Syphilis Outcome
 

Status: Recruiting

Condition Summary: Syphilis

 

Last Updated: 12 Dec 2017

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Last Updated: 18 Sep 2017

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Last Updated: 4 Aug 2016

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