Systemic capillary leak syndrome

Common Name(s)

Systemic capillary leak syndrome

Systemic capillary leak syndrome is a condition in which fluid and proteins leak out of tiny blood vessels and flow into surrounding tissues, resulting in dangerously low blood pressure. Attacks frequently last for several days and require emergency care.  Most cases of capillary leak occur randomly in previously healthy adults.  Treatment involves preventing attacks using medications which may decrease capillary leakage and interfere with hormones that may cause future leakage. Once an attack is underway, treatment is aimed at controlling blood pressure to maintain blood flow to vital organs and prevention of swelling due to fluid accumulation.  Capillary leak syndrome may lead to multiple organ failure, shock and even death.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic capillary leak syndrome" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Systemic capillary leak syndrome" returned 41 free, full-text research articles on human participants. First 3 results:

A p190BRhoGAP mutation and prolonged RhoB activation in fatal systemic capillary leak syndrome.
 

Author(s): Richard W Pierce, Jonathan Merola, John Paul Lavik, Martin S Kluger, Anita Huttner, Mustafa K Khokha, Jordan S Pober

Journal: J. Exp. Med.. 2017 Dec;214(12):3497-3505.

 

We describe a fatal case of pediatric systemic capillary leak (Clarkson's disease) associated with a point mutation in p190BRhoGAP. Dermal microvascular endothelial cells (ECs) isolated from this patient form monolayers with similar levels and distribution of junctional proteins and ...

Last Updated: 31 Dec 1969

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Gemcitabine-induced chronic systemic capillary leak syndrome.
 

Author(s): Ravneet Bajwa, Jason Starr, Karen Daily

Journal:

 

A 56-year-old woman presented with anasarca, hypoalbuminaemia and hypotension following cycle 3 day 1 of adjuvant gemcitabine for stage II pancreatic cancer. Due to the temporal nature of presentation, suspicion for gemcitabine-induced capillary leak syndrome was included in the ...

Last Updated: 31 Dec 1969

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A Case of Refractory Systemic Capillary Leak Syndrome (Clarkson's Disease) during Pregnancy.
 

Author(s): Yukiko Hikasa, Masao Hayashi, Satoshi Suzuki, Hiroshi Morimatsu

Journal: Acta Med. Okayama. 2016 Dec;70(6):497-501.

 

A 32-year-old woman, pregnant with twins, presented with a chief complaint of general fatigue. Her general condition had rapidly deteriorated since her last visit to the primary obstetrician; the patient was then referred to our hospital because of suspected fetal death. She underwent ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Systemic capillary leak syndrome" returned 8 free, full-text review articles on human participants. First 3 results:

Raised Serum Levels of Syndecan-1 (CD138), in a Case of Acute Idiopathic Systemic Capillary Leak Syndrome (SCLS) (Clarkson's Disease).
 

Author(s): Ole Wilhelm Bøe, Kjell Sveen, Magne Børset, Kirk M Druey

Journal:

 

BACKGROUND Systemic capillary leak syndrome (SCLS) (Clarkson's disease) is a rare disorder of unknown etiology, characterized by transient episodes of hypotension, and the microvascular leak of fluids into the peripheral tissues, resulting in edema. Between 80-90% of patients with ...

Last Updated: 31 Dec 1969

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How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis?
 

Author(s): Aline Lopes Bressan, Daniele Pereira, Paula Mota Medeiros, Sueli Carneiro, Luna Azulay-Abulafia

Journal: An Bras Dermatol. ;92(6):826-829.

 

Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and ...

Last Updated: 31 Dec 1969

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Idiopathic systemic capillary leak syndrome (Clarkson disease).
 

Author(s): Kirk M Druey, Samir M Parikh

Journal: J. Allergy Clin. Immunol.. 2017 Sep;140(3):663-670.

 

In 1960, Dr Bayard Clarkson described a woman experiencing sporadic recurrent episodes of shock and anasarca. Plasma from an acute attack induced a shock-like syndrome when injected into rats. The enigmatic systemic capillary leak syndrome (SCLS) named for Dr Clarkson is characterized ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Studies in the Pathogenesis of Systemic Capillary Leak Syndrome
 

Status: Recruiting

Condition Summary: Systemic Capillary Leak Syndrome

 

Last Updated: 14 Sep 2018

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