Systemic lupus erythematosus

Common Name(s)

Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by {93:Oishi et al., 2008}). Genetic Heterogeneity of Systemic Lupus Erythematosus An autosomal recessive form of systemic lupus erythematosus (SLEB16; {614420}) is caused by mutation in the DNASE1L3 gene ({602244}) on chromosome 3p14.3. See MAPPING and MOLECULAR GENETICS sections for a discussion of genetic heterogeneity of susceptibility to SLE.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Systemic lupus erythematosus" returned 4857 free, full-text research articles on human participants. First 3 results:

Diagnosis of systemic lupus erythematosus by presence of Hargraves cells in eosinophilic pleural effusion: Case report.
 

Author(s): Alexia D'Andréa, Damien L Peillet, Christine Serratrice, Pierre-Augute Petignat, Virginie Prendki, Jean-Luc Reny, Jacques Serratrice

Journal: Medicine (Baltimore). 2018 Oct;97(42):e12871.

 

Eosinophilic pleural effusion in elderly patients is most commonly due to malignancies and infections.

Last Updated: 31 Dec 1969

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Slicc damage index score in systemic lupus erythematosus patients and its associated factors.
 

Author(s): Wan Syamimee Wan Ghazali, Saidatul Manera Mohd Daud, Nurashikin Mohammad, Kah Keng Wong

Journal: Medicine (Baltimore). 2018 Oct;97(42):e12787.

 

The aims of this study were to determine damage index in systemic lupus erythematosus (SLE) patients based on Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (SDI) and to determine the laboratory and clinico-demographic ...

Last Updated: 31 Dec 1969

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Red blood cell distribution width-to-platelet ratio as a disease activity-associated factor in systemic lupus erythematosus.
 

Author(s): Siyan Xie, Xuejie Chen

Journal: Medicine (Baltimore). 2018 Sep;97(39):e12342.

 

Although different clinical and experimental parameters have been used to estimate disease activity in systemic lupus erythematosus (SLE) patients, the relationship between red blood cell distribution width-to-platelet ratio (RPR) and disease activity in SLE has not been previously ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Systemic lupus erythematosus" returned 603 free, full-text review articles on human participants. First 3 results:

DNA Damage and Deficiencies in the Mechanisms of Its Repair: Implications in the Pathogenesis of Systemic Lupus Erythematosus.
 

Author(s): Martha Paola Mireles-Canales, Susana Aideé González-Chávez, Celia Maria Quiñonez-Flores, Ever Adán León-López, César Pacheco-Tena

Journal:

 

Systemic lupus erythematosus (SLE) is a perplexing and potentially severe disease, the pathogenesis of which is yet to be understood. SLE is considered to be a multifactorial disease, in which genetic factors, immune dysregulation, and environmental factors, such as ultraviolet radiation, ...

Last Updated: 31 Dec 1969

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The Impact of Vitamin D on the Immunopathophysiology, Disease Activity, and Extra-Musculoskeletal Manifestations of Systemic Lupus Erythematosus.
 

Author(s): Anselm Mak

Journal:

 

Over the past two decades it has been increasingly recognized that vitamin D, aside from its crucial involvement in calcium and phosphate homeostasis and the dynamics of the musculoskeletal system, exerts its influential impact on the immune system. The mechanistic roles that vitamin ...

Last Updated: 31 Dec 1969

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Wilson's disease combined with systemic lupus erythematosus: a case report and literature review.
 

Author(s): Yun Zhang, Dongmei Wang, Wei Wei, Xuejun Zeng

Journal:

 

Wilson's disease (WD) is an inherited disorder in which defective biliary excretion of copper leads to its accumulation, particularly in the liver and brain. Systemic lupus erythematosus (SLE) is a multi-system disorder that can manifest in any system. Cases with concomitant WD and ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Systemic Lupus Erythematosus (SLE) Prospective Observational Cohort Study (SPOCS)
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 13 Nov 2018

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Exploratory Study of DHA in Systemic Lupus Erythematosus Patients
 

Status: Not yet recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 18 Jan 2018

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Safety and Efficacy of AMG 592 in Subjects With Active Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 23 Oct 2018

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