Systemic lupus erythematosus

Common Name(s)

Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by {93:Oishi et al., 2008}). Genetic Heterogeneity of Systemic Lupus Erythematosus An autosomal recessive form of systemic lupus erythematosus (SLEB16; {614420}) is caused by mutation in the DNASE1L3 gene ({602244}) on chromosome 3p14.3. See MAPPING and MOLECULAR GENETICS sections for a discussion of genetic heterogeneity of susceptibility to SLE.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Systemic lupus erythematosus" returned 4675 free, full-text research articles on human participants. First 3 results:

The incidence of cardiovascular events in Italian patients with systemic lupus erythematosus is lower than in North European and American cohorts: implication of disease-associated and traditional risk factors as emerged by a 16-year retrospective GIRRCS study: GIRRCS=Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale.
 

Author(s): Serena Fasano, Domenico Paolo Margiotta, Roberta Gualtierotti, Ada Corrado, Onorina Berardicurti, Daniela Iacono, Luciana Pierro, Antonella Riccardi, Roberto Giacomelli, Francesco Paolo Cantatore, Pier Luigi Meroni, Antonella Afeltra, Gabriele Valentini

Journal: Medicine (Baltimore). 2018 Apr;97(15):e0370.

 

Previous study from our group has pointed out a lower number of cardiovascular (CV) events in Italian patients with systemic lupus erythematosus (SLE) than in North European and American ones. This study aims to assess the incidence of the first CV event in a large, multicenter, Italian ...

Last Updated: 31 Dec 1969

Go To URL
Lupus erythematosus panniculitis in a 10-year-old female child with severe systemic lupus erythematosus: A case report.
 

Author(s): Ruolin Zhang, Xiqiang Dang, Lanjun Shuai, Qingnan He, Xiaojie He, Zhuwen Yi

Journal: Medicine (Baltimore). 2018 Jan;97(3):e9571.

 

Lupus erythematosus panniculitis (LEP) is a rare subset of lupus erythematosus. The incidence of LEP in systemic lupus erythematosus (SLE) ranges from 2% to 5%. In the previous literature, most LEP patients were women aged from 20 to 60 years, while pediatric cases were rare, all ...

Last Updated: 31 Dec 1969

Go To URL
[Lupus enteritis as initial manifestation of systemic lupus erythematosus. Report of one case].
 

Author(s): Manuel Barrera O, Rodrigo Barrera M, Matías de la Rivera V, Javier Vela U, Gustavo Mönckeberg F

Journal: Rev Med Chil. 2017 Oct;145(10):1349-1352.

 

Although gastrointestinal symptoms are not rare in Systemic lupus erythematosus, enteritis is an atypical manifestation of the disease. We report a 54 year-old woman who presented acute symptoms of diarrhea, fever and abdominal pain, receiving empiric antibiotic therapy for bacterial ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Systemic lupus erythematosus" returned 568 free, full-text review articles on human participants. First 3 results:

Concomitant systemic lupus erythematosus and HIV infection: A rare case report and literature review.
 

Author(s): Hong-Yan Liao, Chuan-Min Tao, Jun Su

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9337.

 

Coexisting systemic lupus erythematosus (SLE) and human immunodeficiency virus (HIV) infection cases are rare worldwide. Great challenges are posed on the diagnosis and treatment of such concurrent cases.

Last Updated: 31 Dec 1969

Go To URL
[Unmet needs in systemic lupus erythematosus].
 

Author(s): Kunihiro Ichinose

Journal: Nihon Rinsho Meneki Gakkai Kaishi. 2017 ;40(6):396-407.

 

  Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple lesions that cause inflammation and the production of autoantibodies. Lupus nephritis (LN) and neuropsychiatric SLE (NPSLE) are common organ-threatening manifestations of SLE and result in significant ...

Last Updated: 31 Dec 1969

Go To URL
Differences in clinical features observed between childhood-onset versus adult-onset systemic lupus erythematosus: A systematic review and meta-analysis.
 

Author(s): Pravesh Kumar Bundhun, Alka Kumari, Feng Huang

Journal: Medicine (Baltimore). 2017 Sep;96(37):e8086.

 

Systemic lupus erythematosus (SLE) affects people in childhood (childhood onset) or in adulthood (adult onset). Observational studies that have previously compared childhood-onset versus adult-onset SLE were often restricted to 1 ethnic group, or to a particular area, with a small ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Systemic Lupus Erythematosus (SLE) Prospective Observational Cohort Study (SPOCS)
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 13 Mar 2018

Go to URL
Exploratory Study of DHA in Systemic Lupus Erythematosus Patients
 

Status: Not yet recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 18 Jan 2018

Go to URL
Safety and Efficacy of AMG 592 in Subjects With Active Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 18 Apr 2018

Go to URL