Takayasu arteritis

Common Name(s)

Takayasu arteritis, Takayasu's arteritis, TAK, Pulseless disease, Aortic arch syndrome

Takayasu’s arteritis is a rare form of blood vessel inflammation (vasculitis) that typically affects the large artery that carries blood from your heart to the rest of your body (the aorta), as well as the artery that carries blood from the heart to the lungs (pulmonary artery). Signs and symptoms of Takayasu’s arteritis often occur in two stages. The first stage (systemic stage) may include symptoms such general fatigue, fever, headache, fast and unintentional weight loss, joint pain and sore muscles. The second stage (occlusive stage) develops when inflammation causes the affected arteries to narrow. This narrowing can cause a decrease in blood flow along with a decrease in the amount of oxygen and nutrients that can reach tissues and organs. Symptoms of the second stage can include dizziness, visual problems, shortness of breath, chest or abdominal pain, weakness, change in limb color, fainting, stroke, seizure, or high blood pressure. Symptoms depend on which arteries are inflamed.

The exact cause of Takayasu’s arteritis is not known. The inflamed arteries are believed to be caused by an autoimmune disease, which means the body’s immune cells attack the tissue in the arteries, mistaking it for something foreign (from outside the body). To diagnose the condition, a doctor will collect a medical history, conduct a physical exam, perform blood tests and collect images of the heart, chest and arteries. In some cases, Takayasu’s arteritis can be managed by medication. However, if it becomes severe enough, surgery may be necessary. If you are diagnosed with Takayasu’s arteritis, talk with your doctor to discuss the right treatment plan for you.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Takayasu arteritis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Takayasu arteritis" returned 198 free, full-text research articles on human participants. First 3 results:

Abdominal pain as the presenting symptom of Takayasu arteritis in an adolescent male: A case report.
 

Author(s): Shaobo Yang, Kuiran Dong, Shan Zheng

Journal: Medicine (Baltimore). 2018 Jun;97(26):e11326.

 

Takayasu arteritis (TA) is a chronic granulomatous inflammation affecting the aorta and its main branches. The clinical symptoms are mainly due to arterial claudication and end-organ ischaemia. Abdominal pain is an uncommon manifestation of TA.

Last Updated: 31 Dec 1969

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Revascularization of Concurrent Renal and Cerebral Artery Stenosis in a 14-Year-Old Girl with Takayasu Arteritis and Moyamoya Syndrome.
 

Author(s): Meng Luen Lee, Ming Yuh Chang, Tung Ming Chang, Rei Cheng Yang, Ming Che Chang, Albert D Yang

Journal:

 

Concurrent involvement of bilateral renal and cerebral arteries, usually incurred as stenosis, is rare in childhood-onset Takayasu arteritis (c-TA). We report the case of a 14-year-old girl, with c-TA, presenting with transient ischemic attack after endovascular revascularization ...

Last Updated: 31 Dec 1969

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Takayasu arteritis-related photic and postprandial amaurosis.
 

Author(s): Sze H Wong, Roger E Turbin, Larry P Frohman

Journal:

 

We report the case of a 66-year-old man with Takayasu arteritis who developed photic and postprandial amaurosis occurring at a corticosteroid dose <40 mg per day, despite concurrent methotrexate. The amaurosis resolved with correction of anemia by packed red blood cell transfusion. ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Takayasu arteritis" returned 13 free, full-text review articles on human participants. First 3 results:

Takayasu arteritis presented with acute heart failure: case report and review of literature.
 

Author(s): Xuanqi An, Yechen Han, Bingqing Zhang, Lin Qiao, Yuxing Zhao, Xiaoxiao Guo, Ligang Fang, Wenling Zhu, Quan Fang, Zhujun Shen, Shuyang Zhang

Journal: ESC Heart Fail. 2017 11;4(4):649-654.

 

Acute heart failure due to myocarditis is not common in Takayasu arteritis, let alone in combination with thrombosis affecting both ventricles and pulmonary arteries. The concomitant infection of non-tuberculosis mycobacterium further complicates the clinical scenario and poses challenges ...

Last Updated: 31 Dec 1969

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Application of imaging techniques for Takayasu arteritis.
 

Author(s): Enrico Tombetti, Justin C Mason

Journal: Presse Med. ;46(7-8 Pt 2):e215-e223.

 

Arterial injury with subsequent remodelling and predisposition to arterial stenosis and/or dilation are the hallmarks of Takayasu arteritis. The degree of arterial damage closely aligns with prognosis and therefore its prevention is the predominant aim of therapy. Non-invasive imaging ...

Last Updated: 31 Dec 1969

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Endovascular balloon angioplasty versus stenting in patients with Takayasu arteritis: A meta-analysis.
 

Author(s): Han Saem Jeong, Jae Hyun Jung, Gwan Gyu Song, Sung Jae Choi, Soon Jun Hong

Journal: Medicine (Baltimore). 2017 Jul;96(29):e7558.

 

Symptomatic or significant vascular lesions of Takayasu arteritis (TA) need interventions. Although percutaneous transluminal angioplasty with balloon is a less invasive and safe method, stent implantation in TA can be an alternative option. However, superiority between balloon angioplasty ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

China Takayasu Arteritis Registry (CTA Registry)
 

Status: Recruiting

Condition Summary: TAKAYASU ARTERITIS

 

Last Updated: 13 Nov 2016

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Registration Study of Takayasu's Arteritis in China
 

Status: Recruiting

Condition Summary: Takayasu Arteritis

 

Last Updated: 26 Aug 2018

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Takayasu Arteritis Clinical Trial in China
 

Status: Recruiting

Condition Summary: Takayasu Arteritis

 

Last Updated: 14 Mar 2018

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