Tardive dyskinesia

Common Name(s)

Tardive dyskinesia, Oral facial dyskinesia

Tardive dyskinesia is a neurological movement disorder that is caused by the long-term use of a certain type of medications called neuroleptics. Neuroleptic drugs are usually prescribed for psychiatric conditions, although they may be used to treat gastrointestinal or neurological conditions in some cases. Tardive dyskinesia is primarily characterized by repetitive involuntary movements of the jaw, lips and tongue such as grimacing; sticking out the tongue; and smacking, puckering and pursing the lips. Some affected people may also experience involuntary rapid, jerking movements (chorea) or slow, writhing movements (athetosis) of the arms and/or legs. It is unclear why some people who take neuroleptic medications develop these symptoms while others do not. Treatment for this condition varies but may include stopping or minimizing the use of neuroleptic drugs and/or taking additional medications to to reduce the severity of the symptoms
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Tardive dyskinesia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Tardive dyskinesia" returned 111 free, full-text research articles on human participants. First 3 results:

Two New Drugs for Tardive Dyskinesia Hit the Market.
 

Author(s): Thomas Morrow

Journal: Manag Care. 2018 01;27(1):35-36.

 

Ingrezza and Austedo were approved last year. ICER calculations raise questions about their price.

Last Updated: 31 Dec 1969

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MSBIS: A Multi-Step Biomedical Informatics Screening Approach for Identifying Medications that Mitigate the Risks of Metoclopramide-Induced Tardive Dyskinesia.
 

Author(s): Dong Xu, Alexandrea G Ham, Rickey D Tivis, Matthew L Caylor, Aoxiang Tao, Steve T Flynn, Peter J Economen, Hung K Dang, Royal W Johnson, Vaughn L Culbertson

Journal: EBioMedicine. 2017 Dec;26():132-137.

 

In 2009 the U.S. Food and Drug Administration (FDA) placed a black box warning on metoclopramide (MCP) due to the increased risks and prevalence of tardive dyskinesia (TD). In this study, we developed a multi-step biomedical informatics screening (MSBIS) approach leveraging publicly ...

Last Updated: 31 Dec 1969

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Successful Treatment of Severe Tardive Dyskinesia with Valbenazine, Including a Patient's Perspective.
 

Author(s): Richard C Josiassen, Dawn M Filmyer, Jack Gillean, Syed Sikandar Shah, Tyler E Dietterich, Rita A Shaughnessy

Journal:

 

BACKGROUND Tardive dyskinesia (TD) is a chronic involuntary movement disorder frequently induced by dopamine receptor blockers, particularly first-generation antipsychotics. Until recently, management of TD was restricted to lowering the dose of the current medication, switching to ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Tardive dyskinesia" returned 23 free, full-text review articles on human participants. First 3 results:

Epidemiology, Prevention, and Assessment of Tardive Dyskinesia and Advances in Treatment.
 

Author(s): Christoph U Correll, John M Kane, Leslie L Citrome

Journal: J Clin Psychiatry. ;78(8):1136-1147.

 

​​ Tardive dyskinesia (TD) is a disorder characterized by involuntary movements, typically of the orofacial muscles and also of the extremities and other muscle groups. The condition is associated with exposure to dopamine receptor blocking agents, including antipsychotics. Because ...

Last Updated: 31 Dec 1969

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Systematic review of interventions for treating or preventing antipsychotic-induced tardive dyskinesia.
 

Author(s): Hanna Bergman, Dawn-Marie Walker, Adriani Nikolakopoulou, Karla Soares-Weiser, Clive E Adams

Journal: Health Technol Assess. 2017 08;21(43):1-218.

 

Antipsychotic medication can cause tardive dyskinesia (TD) - late-onset, involuntary, repetitive movements, often involving the face and tongue. TD occurs in > 20% of adults taking antipsychotic medication (first-generation antipsychotics for > 3 months), with this proportion ...

Last Updated: 31 Dec 1969

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Tardive dyskinesia (syndrome): Current concept and modern approaches to its management.
 

Author(s): Paul P Lerner, Chanoch Miodownik, Vladimir Lerner

Journal: Psychiatry Clin. Neurosci.. 2015 Jun;69(6):321-34.

 

Tardive dyskinesia is a serious, disabling and potentially permanent, neurological hyperkinetic movement disorder that occurs after months or years of taking psychotropic drugs. The pathophysiology of tardive dyskinesia is complex, multifactorial and still not fully understood. A ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Repetitive Transcranial Magnetic Stimulation for the Treatment of the Tardive Dyskinesia.
 

Status: Recruiting

Condition Summary: Tardive Dyskinesia

 

Last Updated: 22 Feb 2018

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Safety and Efficacy of Propranolol in the Treatment of Tardive Dyskinesia
 

Status: Recruiting

Condition Summary: Tardive Dyskinesia

 

Last Updated: 21 Sep 2017

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Efficacy and Safety of MT-5199 in Subjects With Tardive Dyskinesia
 

Status: Recruiting

Condition Summary: Tardive Dyskinesia

 

Last Updated: 11 Sep 2018

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