Tarsal-carpal coalition syndrome

Common Name(s)

Tarsal-carpal coalition syndrome, NOG-related-symphalangism spectrum disorder

Tarsal-carpal coalition syndrome (TCDS) is a rare disorder in which certain bones in the hands and/or feet are abnormally fused. The fusion of two adjacent bones is sometimes referred to as a synostosis. In this disorder, the abnormally fused bones may be connected by bone, cartilage, or dense fibrous tissue. Affected individuals may have fusions in the joints of the fingers, toes, wrists, and/or ankles. Individuals affected by TCDS may experience symptoms of limited mobility in the affected joint and pain from early-onset arthritis.

TCDS may be caused by a mutation in the human noggin gene (NOG). When this gene is mutated, the bones do not properly divide into separate pieces during fetal development, and instead remain connected. Bones in the hands or feet may also fuse as a result of infection, trauma, or surgical fixation. However, TCDS usually refers to fusions caused by developmental abnormalities and are present at the time of birth.

Diagnosis of TCDS may be accomplished through a physical exam and medical imaging. Treatment may include physical therapy and exercises to improve motion, as well as surgery. Recovery depends on the amount and extent of the fusions that are present. If you or your child has been diagnosed with TCDS, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Tarsal-carpal coalition syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Tarsal-carpal coalition syndrome" returned 1 free, full-text research articles on human participants. First 3 results:

[Tarsal-carpal coalition syndrome: a familial case].
 

Author(s): S Caino, B Dello Ruso, V Fano, M G Obregón

Journal: An Pediatr (Barc). 2012 Jun;76(6):355-9.

 

Tarsal-carpal coalition syndrome (TCC, OMIM #186570) is an autosomal dominant disorder characterised by fusion of the carpals, tarsals, and phalanges, with the short first metacarpals causing brachydactyly and humeroradial fusion. Mutations in the NOG gene have been reported in many ...

Last Updated: 4 Jun 2012

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The terms "Tarsal-carpal coalition syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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