Temporal lobe seizures

Common Name(s)

Temporal lobe seizures

Temporal lobe seizures are a result of abnormal electrical activity in the temporal lobe. The temporal lobe is located right above the ear and allows individuals to understand speech. It also plays a role in the personality, memory, and behavior of a person. Experiencing déjà vu (the illusion of already experiencing a first time event), a sudden sense of fear, memories, and hallucinations (seeing things that are not real) are a few symptoms of these seizures. Temporal lobe seizures can either be really mild or complex. In a mild seizure a person may not even know he/she is experiencing one. During a complex seizure one may become unresponsive, make repetitive motions with the hands and lips, or lose consciousness.

Experts do not know the exact cause of these seizures. They may be a result of scar tissue in the temporal lobe, head trauma, infections, injuries during birth or childhood, or high fever. An individual can either experience a single seizure or multiple ones, and the timing can range from two seconds to three minutes. There are many types of medications available to treat this condition. If medication does not work, then a surgery called temporal lobectomy may be an option. Talk with your doctor to decide which treatment option is best for you. Support groups are also good resources for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Temporal lobe seizures" for support, advocacy or research.

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Epilepsy Foundation - Home Office

The mission of the Epilepsy Foundation is to stop seizures and SUDEP, find a cure and overcome the challenges created by epilepsy through efforts including education, advocacy and research to accelerate ideas into therapies.

Last Updated: 28 Apr 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Temporal lobe seizures" for support, advocacy or research.

Logo
Epilepsy Foundation - Home Office

The mission of the Epilepsy Foundation is to stop seizures and SUDEP, find a cure and overcome the challenges created by epilepsy through efforts including education, advocacy and research to accelerate ideas into therapies.

http://www.epilepsy.com

Last Updated: 28 Apr 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Temporal lobe seizures" returned 82 free, full-text research articles on human participants. First 3 results:

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy.
 

Author(s): Alba Jimenez-Pacheco, Miguel Diaz-Hernandez, Marina Arribas-Blázquez, Amaya Sanz-Rodriguez, Luis A Olivos-Oré, Antonio R Artalejo, Mariana Alves, Michael Letavic, M Teresa Miras-Portugal, Ronan M Conroy, Norman Delanty, Michael A Farrell, Donncha F O'Brien, Anindya Bhattacharya, Tobias Engel, David C Henshall

Journal: J. Neurosci.. 2016 Jun;36(22):5920-32.

 

Neuroinflammation is thought to contribute to the pathogenesis and maintenance of temporal lobe epilepsy, but the underlying cell and molecular mechanisms are not fully understood. The P2X7 receptor is an ionotropic receptor predominantly expressed on the surface of microglia, although ...

Last Updated: 2 Jun 2016

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The temporal relation between seizure onset and arousal-awakening in temporal lobe seizures.
 

Author(s): Sadiye Gumusyayla, Abidin Erdal, F Irsel Tezer, Serap Saygi

Journal: Seizure. 2016 Jul;39():24-27.

 

Our main aim was to determine the time interval between the seizure onsets and arousal-awakening related to these seizures in patients with temporal lobe epilepsy (TLE) and to discuss the role of lateralization on arousal-awakening mechanisms.

Last Updated: 25 Jun 2016

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Community structure analysis of transcriptional networks reveals distinct molecular pathways for early- and late-onset temporal lobe epilepsy with childhood febrile seizures.
 

Author(s): Carlos Alberto Moreira-Filho, Silvia Yumi Bando, Fernanda Bernardi Bertonha, Priscila Iamashita, Filipi Nascimento Silva, Luciano da Fontoura Costa, Alexandre Valotta Silva, Luiz Henrique Martins Castro, Hung-Tzu Wen

Journal:

 

Age at epilepsy onset has a broad impact on brain plasticity and epilepsy pathomechanisms. Prolonged febrile seizures in early childhood (FS) constitute an initial precipitating insult (IPI) commonly associated with mesial temporal lobe epilepsy (MTLE). FS-MTLE patients may have early ...

Last Updated: 27 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Temporal lobe seizures" returned 3 free, full-text review articles on human participants. First 3 results:

Epilepsy surgery in patients with bilateral temporal lobe seizures: a systematic review.
 

Author(s): Yahya Aghakhani, Xiaorong Liu, Nathalie Jette, Samuel Wiebe

Journal: Epilepsia. 2014 Dec;55(12):1892-901.

 

We explored the association between magnetic resonance imaging (MRI) lesion, degree of seizure laterality on intracranial electroencephalography (iEEG), and seizure outcome in patients with ambiguous or presumed bilateral temporal lobe epilepsy (BiTLE) on scalp EEG. We systematically ...

Last Updated: 5 Jan 2015

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Origins of temporal lobe epilepsy: febrile seizures and febrile status epilepticus.
 

Author(s): Katelin P Patterson, Tallie Z Baram, Shlomo Shinnar

Journal: Neurotherapeutics. 2014 Apr;11(2):242-50.

 

Temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS) commonly arise following early-life long seizures, and especially febrile status epilepticus (FSE). However, there are major gaps in our knowledge regarding the causal relationships of FSE, TLE, HS and cognitive disturbances ...

Last Updated: 23 Apr 2014

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Temporal lobe epilepsy: where do the seizures really begin?
 

Author(s): Edward H Bertram

Journal: Epilepsy Behav. 2009 Jan;14 Suppl 1():32-7.

 

Defining precisely the site of seizure onset has important implications for our understanding of the pathophysiology of temporal lobe epilepsy, as well as for the surgical treatment of the disorder. Removal of the limbic areas of the medial temporal lobe has led to a high rate of ...

Last Updated: 17 Nov 2008

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Stereotactic Laser Ablation for Temporal Lobe Epilepsy
 

Status: Recruiting

Condition Summary: Temporal Lobe Epilepsy

 

Last Updated: 13 Jul 2017

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Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE)
 

Status: Recruiting

Condition Summary: Mesial Temporal Lobe Epilepsy

 

Last Updated: 16 Feb 2017

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Low Frequency TMS for Depression in Epilepsy
 

Status: Recruiting

Condition Summary: Temporal Lobe Epilepsy; Depressions, Refractory

 

Last Updated: 3 Apr 2017

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