Thoracic aortic aneurysm

Common Name(s)

Thoracic aortic aneurysm

A thoracic aortic aneurysm is a weakening of a portion of the upper aorta, the body's largest artery (a type of blood vessel that delivers blood to the organs). The aorta is a long, thick vessel that extends from the lower torso to the upper chest. An aneurysm in the chest area is called a "thoracic aneurysm." An aneurysm in the lower torso is called an "abdominal aneurysm." The aorta can be weakened by a variety of factors, including high blood pressure, atherosclerosis (blood vessel hardening), older age, and a family history for aneurysm (genetic factors). An aneurysm forms when a weakened portion of the aorta losses stiffness, causing a portion of the aortic wall (the casing of aorta) to bulge outwards. If the aneurysm bursts, it can be lethal. But once identified, there are many ways aneurysms can be managed and treated to prevent bursting. Most aneurysms do not have any symptoms, so physicians will usually conduct investigative screens for those at risk for the condition via ultrasound, MRI or CT-scan. Treatment for an aortic aneurysm depends on the size and growth of the aneurysm and the health of the patient. For small, stable cases, the condition is usually managed with medication, healthy eating habits, and frequent observation. For large and/or growing cases, surgery may be required to repair the aneurysm site. A burst aortic aneurysm causes extreme pain and bleeding and causes death within minutes to hours if left untreated. Having an aneurysm increases the risk of blood clots and stroke (clots are more likely to form in the ballooned aortic wall). The risk of clots can be lowered with physical activity, avoiding long periods of inactivity, and certain medicines.

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Condition Specific Organizations

Following organizations serve the condition "Thoracic aortic aneurysm" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Thoracic aortic aneurysm" returned 221 free, full-text research articles on human participants. First 3 results:

ER stress dependent microparticles derived from smooth muscle cells promote endothelial dysfunction during thoracic aortic aneurysm and dissection.
 

Author(s): Li-Xin Jia, Wen-Mei Zhang, Tao-Tao Li, Yan Liu, Chun-Mei Piao, You-Cai Ma, Yu Lu, Yuan Wang, Ting-Ting Liu, Yong-Fen Qi, Jie Du

Journal:

 

The degeneration of vascular smooth muscle cell(s) (SMC) is one of the key features of thoracic aortic aneurysm and dissection (TAAD). We and others have shown that elevated endoplasmic reticulum (ER) stress causes SMC loss and TAAD formation, however, the mechanism of how SMC dysfunction ...

Last Updated: 31 Dec 1969

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Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms.
 

Author(s): Premakumari Venkatesh, Julie Phillippi, Sasanka Chukkapalli, Mercedes Rivera-Kweh, Irina Velsko, Thomas Gleason, Paul VanRyzin, Seyed Hossein Aalaei-Andabili, Ravi Kiran Ghanta, Thomas Beaver, Edward Kar Leung Chan, Lakshmyya Kesavalu

Journal:

 

Altered microRNA expression is implicated in cardiovascular diseases. Our objective was to determine microRNA signatures in thoracic aortic aneurysms (TAAs) and abdominal aortic aneurysms (AAAs) compared with control non-aneurysmal aortic specimens. We evaluated the expression of ...

Last Updated: 31 Dec 1969

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Simultaneous endovascular repairs of concomitant ruptured abdominal aortic aneurysm and huge silent thoracic aortic aneurysm.
 

Author(s): Ahmet Karabulut, Selim Aydın

Journal: Indian Heart J. 2016 Sep;68 Suppl 2():S66-S68.

 

Ruptured abdominal aortic aneurysm (rAAA) is an emergent condition that carries higher mortality rate. Although there had been development of interventional and surgical technique besides improved critical care, mortality rates were still varied between 35 and 53% in the reported ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Thoracic aortic aneurysm" returned 19 free, full-text review articles on human participants. First 3 results:

Behcet's disease with recurrent thoracic aortic aneurysm combined with femoral artery aneurysm: a case report and literature review.
 

Author(s): Shi-Huai Zhang, Fu-Xian Zhang

Journal:

 

Aneurysm or pseudoaneurysm is the main vascular complication of Behcet's disease. Most hospitals adopt endovascular treatment.

Last Updated: 31 Dec 1969

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Editor's Choice - Incidence of Stroke Following Thoracic Endovascular Aortic Repair for Descending Aortic Aneurysm: A Systematic Review of the Literature with Meta-analysis.
 

Author(s): R S von Allmen, B Gahl, J T Powell

Journal: Eur J Vasc Endovasc Surg. 2017 02;53(2):176-184.

 

Stroke is an increasingly recognised complication following thoracic endovascular aortic repair (TEVAR). The aim of this study was to systematically synthesise the published data on perioperative stroke incidence during TEVAR for patients with descending thoracic aneurysmal disease ...

Last Updated: 31 Dec 1969

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A Case Based Approach to Clinical Genetics of Thoracic Aortic Aneurysm/Dissection.
 

Author(s): Betti Giusti, Stefano Nistri, Elena Sticchi, Rosina De Cario, Rosanna Abbate, Gian Franco Gensini, Guglielmina Pepe

Journal: Biomed Res Int. 2016 ;2016():9579654.

 

Thoracic aortic aneurysm/dissection (TAAD) is a potential lethal condition with a rising incidence. This condition may occur sporadically; nevertheless, it displays familial clustering in >20% of the cases. Family history confers a six- to twentyfold increased risk of TAAD and has ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effective Treatments for Thoracic Aortic Aneurysms (ETTAA Study): A Prospective Cohort Study
 

Status: Recruiting

Condition Summary: Thoracic Aortic Aneurysm

 

Last Updated: 5 May 2016

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Obstructive Sleep Apnoea in Adolescents With Thoracic Aortic Aneurysm
 

Status: Recruiting

Condition Summary: Thoracic Aortic Aneurysm Without Rupture; Obstructive Sleep Apnea

 

Last Updated: 9 Jan 2018

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Biomechanical and Microstructural Properties of Ascending Aortic Aneurysms
 

Status: Recruiting

Condition Summary: Thoracic Aortic Aneurysms

 

Last Updated: 2 May 2017

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