Thoracic aortic aneurysm

Common Name(s)

Thoracic aortic aneurysm

A thoracic aortic aneurysm is a weakening of a portion of the upper aorta, the body's largest artery (a type of blood vessel that delivers blood to the organs). The aorta is a long, thick vessel that extends from the lower torso to the upper chest. An aneurysm in the chest area is called a "thoracic aneurysm." An aneurysm in the lower torso is called an "abdominal aneurysm." The aorta can be weakened by a variety of factors, including high blood pressure, atherosclerosis (blood vessel hardening), older age, and a family history for aneurysm (genetic factors). An aneurysm forms when a weakened portion of the aorta losses stiffness, causing a portion of the aortic wall (the casing of aorta) to bulge outwards. If the aneurysm bursts, it can be lethal. But once identified, there are many ways aneurysms can be managed and treated to prevent bursting. Most aneurysms do not have any symptoms, so physicians will usually conduct investigative screens for those at risk for the condition via ultrasound, MRI or CT-scan. Treatment for an aortic aneurysm depends on the size and growth of the aneurysm and the health of the patient. For small, stable cases, the condition is usually managed with medication, healthy eating habits, and frequent observation. For large and/or growing cases, surgery may be required to repair the aneurysm site. A burst aortic aneurysm causes extreme pain and bleeding and causes death within minutes to hours if left untreated. Having an aneurysm increases the risk of blood clots and stroke (clots are more likely to form in the ballooned aortic wall). The risk of clots can be lowered with physical activity, avoiding long periods of inactivity, and certain medicines.

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Condition Specific Organizations

Following organizations serve the condition "Thoracic aortic aneurysm" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Thoracic aortic aneurysm" returned 224 free, full-text research articles on human participants. First 3 results:

An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm.
 

Author(s): Christian L Lino Cardenas, Chase W Kessinger, Yisha Cheng, Carolyn MacDonald, Thomas MacGillivray, Brian Ghoshhajra, Luai Huleihel, Saifar Nuri, Ashish S Yeri, Farouc A Jaffer, Naftali Kaminski, Patrick Ellinor, Neal L Weintraub, Rajeev Malhotra, Eric M Isselbacher, Mark E Lindsay

Journal:

 

Thoracic aortic aneurysm (TAA) has been associated with mutations affecting members of the TGF-β signaling pathway, or components and regulators of the vascular smooth muscle cell (VSMC) actomyosin cytoskeleton. Although both clinical groups present similar phenotypes, the existence ...

Last Updated: 31 Dec 1969

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Detection of Pathological Changes in the Aorta during Thoracic Aortic Aneurysm Progression on Molecular Level.
 

Author(s): Miroslava Rabajdová, Peter Urban, Ivana Špaková, Artemiou Panagiotis, Michaela Ferenčáková, Dušan Rybár, Nikita Bobrov, František Sabol, Mária Mareková

Journal: Dis. Markers. 2017 ;2017():9185934.

 

The progression of thoracic aortic aneurysm depends on regulation of aortic wall homeostasis and on changes in the structural components of the extracellular matrix, which are affected by multiple molecular signalling pathways. We decided to correlate the diameter of ascending thoracic ...

Last Updated: 31 Dec 1969

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Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation.
 

Author(s): Xiang Li, Qin Fang, Xiaohong Tian, Xiaohong Wang, Qiang Ao, Weijian Hou, Hao Tong, Jun Fan, Shuling Bai

Journal: Mol Med Rep. 2017 Oct;16(4):4455-4462.

 

Angiogenesis is an important process in the pathogenesis of aortic aneurysm. The aim of the present study was to investigate the angiogenic balance and the expression of vascular endothelial growth factor (VEGF) in thoracic aortic aneurysm (TAA). A previous study demonstrated that ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Thoracic aortic aneurysm" returned 21 free, full-text review articles on human participants. First 3 results:

Varying Evidence on Deep Hypothermic Circulatory Arrest in Thoracic Aortic Aneurysm Surgery.
 

Author(s): Prity Gupta, Amer Harky, Saleem Jahangeer, Benjamin Adams, Mohamad Bashir

Journal:

 

Cardiovascular surgeons have long debated the safe duration of deep hypothermic circulatory arrest during thoracic aortic aneurysm surgery. The rationale for using adjunctive cerebral perfusion (or not) is to achieve the best technical aortic repair with the lowest risk of morbidity ...

Last Updated: 31 Dec 1969

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Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease.
 

Author(s): Calogera Pisano, Carmela Rita Balistreri, Alessandro Ricasoli, Giovanni Ruvolo

Journal: Mediators Inflamm.. 2017 ;2017():1274034.

 

Medial degeneration associated with thoracic aortic aneurysm and acute aortic dissection was originally described by Erdheim as a noninflammatory lesion related to the loss of smooth muscle cells and elastic fibre fragmentation in the media. Recent evidences propose the strong role ...

Last Updated: 31 Dec 1969

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Spinal cord injury after thoracic endovascular aortic aneurysm repair.
 

Author(s): Hamdy Awad, Mohamed Ehab Ramadan, Hosam F El Sayed, Daniel A Tolpin, Esmerina Tili, Charles D Collard

Journal: Can J Anaesth. 2017 Dec;64(12):1218-1235.

 

Thoracic endovascular aortic aneurysm repair (TEVAR) has become a mainstay of therapy for aneurysms and other disorders of the thoracic aorta. The purpose of this narrative review article is to summarize the current literature on the risk factors for and pathophysiology of spinal ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effective Treatments for Thoracic Aortic Aneurysms (ETTAA Study): A Prospective Cohort Study
 

Status: Recruiting

Condition Summary: Thoracic Aortic Aneurysm

 

Last Updated: 5 May 2016

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Obstructive Sleep Apnoea in Adolescents With Thoracic Aortic Aneurysm
 

Status: Recruiting

Condition Summary: Thoracic Aortic Aneurysm Without Rupture; Obstructive Sleep Apnea

 

Last Updated: 9 Jan 2018

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Biomechanical and Microstructural Properties of Ascending Aortic Aneurysms
 

Status: Recruiting

Condition Summary: Thoracic Aortic Aneurysms

 

Last Updated: 2 May 2017

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