Thoracic aortic aneurysm

Common Name(s)

Thoracic aortic aneurysm

A thoracic aortic aneurysm is a weakening of a portion of the upper aorta, the body's largest artery (a type of blood vessel that delivers blood to the organs). The aorta is a long, thick vessel that extends from the lower torso to the upper chest. An aneurysm in the chest area is called a "thoracic aneurysm." An aneurysm in the lower torso is called an "abdominal aneurysm." The aorta can be weakened by a variety of factors, including high blood pressure, atherosclerosis (blood vessel hardening), older age, and a family history for aneurysm (genetic factors). An aneurysm forms when a weakened portion of the aorta losses stiffness, causing a portion of the aortic wall (the casing of aorta) to bulge outwards. If the aneurysm bursts, it can be lethal. But once identified, there are many ways aneurysms can be managed and treated to prevent bursting. Most aneurysms do not have any symptoms, so physicians will usually conduct investigative screens for those at risk for the condition via ultrasound, MRI or CT-scan. Treatment for an aortic aneurysm depends on the size and growth of the aneurysm and the health of the patient. For small, stable cases, the condition is usually managed with medication, healthy eating habits, and frequent observation. For large and/or growing cases, surgery may be required to repair the aneurysm site. A burst aortic aneurysm causes extreme pain and bleeding and causes death within minutes to hours if left untreated. Having an aneurysm increases the risk of blood clots and stroke (clots are more likely to form in the ballooned aortic wall). The risk of clots can be lowered with physical activity, avoiding long periods of inactivity, and certain medicines.

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Condition Specific Organizations

Following organizations serve the condition "Thoracic aortic aneurysm" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Thoracic aortic aneurysm" returned 227 free, full-text research articles on human participants. First 3 results:

An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm.
 

Author(s): Christian L Lino Cardenas, Chase W Kessinger, Yisha Cheng, Carolyn MacDonald, Thomas MacGillivray, Brian Ghoshhajra, Luai Huleihel, Saifar Nuri, Ashish S Yeri, Farouc A Jaffer, Naftali Kaminski, Patrick Ellinor, Neal L Weintraub, Rajeev Malhotra, Eric M Isselbacher, Mark E Lindsay

Journal:

 

Thoracic aortic aneurysm (TAA) has been associated with mutations affecting members of the TGF-β signaling pathway, or components and regulators of the vascular smooth muscle cell (VSMC) actomyosin cytoskeleton. Although both clinical groups present similar phenotypes, the existence ...

Last Updated: 31 Dec 1969

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Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation.
 

Author(s): Xiang Li, Qin Fang, Xiaohong Tian, Xiaohong Wang, Qiang Ao, Weijian Hou, Hao Tong, Jun Fan, Shuling Bai

Journal: Mol Med Rep. 2017 Oct;16(4):4455-4462.

 

Angiogenesis is an important process in the pathogenesis of aortic aneurysm. The aim of the present study was to investigate the angiogenic balance and the expression of vascular endothelial growth factor (VEGF) in thoracic aortic aneurysm (TAA). A previous study demonstrated that ...

Last Updated: 31 Dec 1969

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A Functional Variant of SMAD4 Enhances Thoracic Aortic Aneurysm and Dissection Risk through Promoting Smooth Muscle Cell Apoptosis and Proteoglycan Degradation.
 

Author(s): Ying Wang, Hao-Yue Huang, Guang-Liang Bian, Yun-Sheng Yu, Wen-Xue Ye, Fei Hua, Yi-Huan Chen, Zhen-Ya Shen

Journal: EBioMedicine. 2017 Jul;21():197-205.

 

Recent studies indicate important roles for SMAD4 in SMCs proliferation, extracellular matrix maintenance, and blood vessel remodeling. However, the genetic effects of SMAD4 in the pathogenesis of thoracic aortic aneurysm and dissection (TAAD) are still largely unknown. Here we identified ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Thoracic aortic aneurysm" returned 19 free, full-text review articles on human participants. First 3 results:

Behcet's disease with recurrent thoracic aortic aneurysm combined with femoral artery aneurysm: a case report and literature review.
 

Author(s): Shi-Huai Zhang, Fu-Xian Zhang

Journal:

 

Aneurysm or pseudoaneurysm is the main vascular complication of Behcet's disease. Most hospitals adopt endovascular treatment.

Last Updated: 31 Dec 1969

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Editor's Choice - Incidence of Stroke Following Thoracic Endovascular Aortic Repair for Descending Aortic Aneurysm: A Systematic Review of the Literature with Meta-analysis.
 

Author(s): R S von Allmen, B Gahl, J T Powell

Journal: Eur J Vasc Endovasc Surg. 2017 02;53(2):176-184.

 

Stroke is an increasingly recognised complication following thoracic endovascular aortic repair (TEVAR). The aim of this study was to systematically synthesise the published data on perioperative stroke incidence during TEVAR for patients with descending thoracic aneurysmal disease ...

Last Updated: 31 Dec 1969

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A Case Based Approach to Clinical Genetics of Thoracic Aortic Aneurysm/Dissection.
 

Author(s): Betti Giusti, Stefano Nistri, Elena Sticchi, Rosina De Cario, Rosanna Abbate, Gian Franco Gensini, Guglielmina Pepe

Journal: Biomed Res Int. 2016 ;2016():9579654.

 

Thoracic aortic aneurysm/dissection (TAAD) is a potential lethal condition with a rising incidence. This condition may occur sporadically; nevertheless, it displays familial clustering in >20% of the cases. Family history confers a six- to twentyfold increased risk of TAAD and has ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effective Treatments for Thoracic Aortic Aneurysms (ETTAA Study): A Prospective Cohort Study
 

Status: Recruiting

Condition Summary: Thoracic Aortic Aneurysm

 

Last Updated: 5 May 2016

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Obstructive Sleep Apnoea in Adolescents With Thoracic Aortic Aneurysm
 

Status: Recruiting

Condition Summary: Thoracic Aortic Aneurysm Without Rupture; Obstructive Sleep Apnea

 

Last Updated: 9 Jan 2018

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Biomechanical and Microstructural Properties of Ascending Aortic Aneurysms
 

Status: Recruiting

Condition Summary: Thoracic Aortic Aneurysms

 

Last Updated: 2 May 2017

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