Thyrotoxic periodic paralysis

Common Name(s)

Thyrotoxic periodic paralysis

Thyrotoxic periodic paralysis is a sporadic muscle disorder characterized by episodic attacks of weakness associated with hypokalemia in individuals with hyperthyroidism. The paralysis resolves upon treatment of hyperthyroidism. The disorder is most common among males of Asian descent, including Chinese, Japanese, Vietnamese, Filipino, and Koreans, although it occurs less commonly in individuals of Caucasian background. Thyrotoxic periodic paralysis is clinically similar to hereditary hypokalemic periodic paralysis (HOKPP; {170400}), but the paralysis in TTPP occurs only in the presence of hyperthyroidism. TTPP can also be precipitated by factors that result in hypokalemia, such as carbohydrate ingestion and rest after exercise (review by {9:Kung, 2006}). Genetic Heterogeneity of Thyrotoxic Periodic Paralysis See also TTPP2 ({613239}), conferred by variation in the KCNJ18 gene ({613236}) on chromosome 17p11, and TTPP3 ({614834}), mapped to chromosome 17q24.
 

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Condition Specific Organizations

Following organizations serve the condition "Thyrotoxic periodic paralysis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Thyrotoxic periodic paralysis" returned 59 free, full-text research articles on human participants. First 3 results:

Thyrotoxic hypokalemic periodic paralysis in a Turkish patient presenting with a U wave on ECG.
 

Author(s): Emre Gezer, Banu Şarer Yurekli, Gokçen Unal Kocabas

Journal: Hormones (Athens). 2016 Jul;15(3):464-465.

 

Last Updated: 31 Dec 1969

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A case of thyrotoxic periodic paralysis with respiratory failure in an African American woman.
 

Author(s): Denise L Shields

Journal: Am. J. Crit. Care. 2015 May;24(3):264-7.

 

Thyrotoxic periodic paralysis is an acute endocrine emergency characterized by hyperthyroidism, profound muscle weakness and/or paralysis, and hypokalemia that is not due to potassium deficiency. Typically described in young males of Asian descent, it is becoming increasingly recognized ...

Last Updated: 31 Dec 1969

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The clinical and genetic features in a cohort of mainland Chinese patients with thyrotoxic periodic paralysis.
 

Author(s): Xiaobing Li, Sheng Yao, Yining Xiang, Xiaolei Zhang, Xiangbing Wu, Laimin Luo, Haihua Huang, Min Zhu, Hui Wan, Daojun Hong

Journal:

 

Thyrotoxic periodic paralysis (TPP) is a life-threatening channelopathy manifesting as recurrent episodes of hypokalemia and muscle weakness in the presence of hyperthyroidism. Recent findings indicate defects of inward rectifying K+ (Kir) channels are associated with some TPP patients. ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Thyrotoxic periodic paralysis" returned 5 free, full-text review articles on human participants. First 3 results:

Mechanism of thyrotoxic periodic paralysis.
 

Author(s): Shih-Hua Lin, Chou-Long Huang

Journal: J. Am. Soc. Nephrol.. 2012 Jun;23(6):985-8.

 

The pathogenesis of thyrotoxic periodic paralysis has long been thought related to increased Na(+)-K(+) ATPase activity stimulated by thyroid hormone and/or hyperadrenergic activity and hyperinsulinemia. This mechanism alone, however, cannot adequately explain how hypokalemia occurs ...

Last Updated: 31 Dec 1969

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Thyrotoxic periodic paralysis: a case report and literature review.
 

Author(s): M J Barahona, I Vinagre, L Sojo, J M Cubero, Antonio Pérez

Journal: Clin Med Res. 2009 Sep;7(3):96-8.

 

We describe a 37-year-old man with a 4-month history of episodic muscular weakness, involving mainly lower-limbs. Hypokalemia was documented in one episode and managed with intravenous potassium chloride. Hyperthyroidism was diagnosed 4 months after onset of attacks because of mild ...

Last Updated: 31 Dec 1969

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Thyrotoxic periodic paralysis: an overview.
 

Author(s): Chang-Hsun Hsieh, Shi-Wen Kuo, Dee Pei, Yi-Jen Hung, Sandra Chyi-Fan, Ling-I Wu, Chih-Tsueng He, Tsao-Chin Yang, Wei-Cheng Lian, Lee Chien-Hsing

Journal: Ann Saudi Med. ;24(6):418-22.

 

Thyrotoxic periodic paralysis (TPP) is a fairly common manifestation of hyperthyroidism in Asian populations, with an incidence of about 1.9% in thyrotoxic patients, but it is rarely diagnosed among Caucasians and blacks in the Western world. The diagnosis often can be made on the ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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