Tropical spastic paraparesis

Common Name(s)

Tropical spastic paraparesis

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Tropical spastic paraparesis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Tropical spastic paraparesis" returned 111 free, full-text research articles on human participants. First 3 results:

Balance, functional mobility, and fall occurrence in patients with human T-cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis: a cross-sectional study.
 

Author(s): Erika Pedreira da Fonseca, Katia Nunes Sá, Rebeca Freitas Reis Nunes, Antônio Carlos Ribeiro Junior, Síntia Freitas Bastos Lira, Elen Beatriz Pinto

Journal: Rev. Soc. Bras. Med. Trop.. ;51(2):162-167.

 

Human T-cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) may lead to reduced functional mobility and balance. It is important to establish specific parameters that identify these changes and predict the risk of falls in these patients. The ...

Last Updated: 31 Dec 1969

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Temporal trends in Human T-Lymphotropic virus 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) incidence in Martinique over 25 years (1986-2010).
 

Author(s): Stephane Olindo, Severine Jeannin, Martine Saint-Vil, Aissatou Signate, Mireille Edimonana-Kaptue, Julien Joux, Harold Merle, Pascale Richard, Samuel Granjeaud, Philippe Cabre, Didier Smadja, Raymond Cesaire, Agnes Lezin

Journal:

 

Human T-lymphotropic virus type 1 (HTLV-1) has been discovered in 1980 and has been linked to tropical spastic paraparesis (HAM/TSP) in 1985 in Martinique. There is no data on HAM/TSP incidence trends. We report, in the present work, the temporal trends incidence of HAM/TSP in Martinique ...

Last Updated: 31 Dec 1969

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The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis.
 

Author(s): Mineki Saito, Hiroe Sejima, Tadasuke Naito, Hiroshi Ushirogawa, Toshio Matsuzaki, Eiji Matsuura, Yuetsu Tanaka, Tatsufumi Nakamura, Hiroshi Takashima

Journal:

 

Chemokine (C-C motif) ligand 1 (CCL1) is produced by activated monocytes/ macrophages and T-lymphocytes, and acts as a potent attractant for Th2 cells and a subset of T-regulatory (Treg) cells. Previous reports have indicated that CCL1 is overexpressed in adult T-cell leukemia cells, ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Tropical spastic paraparesis" returned 9 free, full-text review articles on human participants. First 3 results:

[Tropical spastic paraparesis: a report of a new case in Spain].
 

Author(s): Luciana Midaglia, Antonio Pato-Pato, Iria Rodriguez-Constenla, Eloísa Santos-Armentia, Iciar Cimas-Hernando, María Lopez-Fernandez, Delicias Munoz-Garcia, Candelas Valeiras-Munoz, José R Lorenzo-Gonzalez

Journal: Rev Neurol. 2014 Jun;58(12):573-5.

 

Last Updated: 31 Dec 1969

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HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP): the role of HTLV-I-infected Th1 cells in the pathogenesis, and therapeutic strategy.
 

Author(s): Tatsufumi Nakamura

Journal: Folia Neuropathol. 2009 ;47(2):182-94.

 

Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic progressive myelopathy characterized by bilateral pyramidal tract involvement with sphincteric disturbances. The primary neuropathological feature of HAM/TSP is chronic ...

Last Updated: 31 Dec 1969

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Treatment of HTLV-I-associated myelopathy/tropical spastic paraparesis: toward rational targeted therapy.
 

Author(s): Unsong Oh, Steven Jacobson

Journal: Neurol Clin. 2008 Aug;26(3):781-97, ix-x.

 

The treatment of HAM/TSP is a challenge. No agent has shown to significantly modify the long-term disability associated with HAM/TSP. Advances in our understanding of the pathogenesis of HAM/TSP have led to the identification of several biomarkers and therapeutic targets. Clinical ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 Infection
 

Status: Recruiting

Condition Summary: HTLV-I Infections; Tropical Spastic Paraparesis

 

Last Updated: 20 Nov 2017

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Evaluation of Patients With HAM/TSP
 

Status: Recruiting

Condition Summary: HTLV-I Infection; Tropical Spastic Paraparesis

 

Last Updated: 8 Aug 2018

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