Typhus

Common Name(s)

Typhus

Typhus is a general term for a group of diseases passed on by lice, flea, tick, and other insect bites. Types of typhus include epidemic typhus, scrub typhus, murine typhus. Common symptoms of most typhus cases include fever, headache, muscle aches, rapid breathing, and rash. Typhus is uncommon in the United States and can be prevented by avoiding contact with rats and keeping pets treated for ticks and fleas. Usually typhus can be cured with antibiotics.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Typhus" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Typhus" returned 394 free, full-text research articles on human participants. First 3 results:

Increased level and interferon-γ production of circulating natural killer cells in patients with scrub typhus.
 

Author(s): Seung-Ji Kang, Hye-Mi Jin, Young-Nan Cho, Seong Eun Kim, Uh Jin Kim, Kyung-Hwa Park, Hee-Chang Jang, Sook-In Jung, Seung-Jung Kee, Yong-Wook Park

Journal:

 

Natural killer (NK) cells are essential immune cells against several pathogens. Not much is known regarding the roll of NK cells in Orientia tsutsugamushi infection. Thus, this study aims to determine the level, function, and clinical relevance of NK cells in patients with scrub typhus.

Last Updated: 27 Jul 2017

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Seroprevalence of Scrub Typhus, Typhus, and Spotted Fever Among Rural and Urban Populations of Northern Vietnam.
 

Author(s): Nguyen Vu Trung, Le Thi Hoi, Nguyen Thi Hong Thuong, Tran Khanh Toan, Tran Thi Kieu Huong, Tran Mai Hoa, Annette Fox, Nguyen van Kinh, H Rogier van Doorn, Heiman F L Wertheim, Juliet E Bryant, Behzad Nadjm

Journal: Am. J. Trop. Med. Hyg.. 2017 May;96(5):1084-1087.

 

AbstractRickettsial infections are recognized as important causes of fever throughout southeast Asia. Herein, we determined the seroprevalence to rickettsioses within rural and urban populations of northern Vietnam. Prevalence of individuals with evidence of prior rickettsial infections ...

Last Updated: 13 May 2017

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Fatal Flea-Borne Typhus in Texas: A Retrospective Case Series, 1985-2015.
 

Author(s): Emily G Pieracci, Nicole Evert, Naomi A Drexler, Bonny Mayes, Inger Vilcins, Philip Huang, Jill Campbell, Casey Barton Behravesh, Christopher D Paddock

Journal: Am. J. Trop. Med. Hyg.. 2017 May;96(5):1088-1093.

 

AbstractFlea-borne (murine) typhus is a global rickettsiosis caused by Rickettsia typhi. Although flea-borne typhus is no longer nationally notifiable, cases are reported for surveillance purposes in a few U.S. states. The infection is typically self-limiting, but may be severe or ...

Last Updated: 13 May 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Typhus" returned 19 free, full-text review articles on human participants. First 3 results:

Comparative effectiveness of azithromycin for treating scrub typhus: A PRISMA-compliant systematic review and meta-analysis.
 

Author(s): Szu-Chia Lee, Yu-Jyun Cheng, Chao-Hsu Lin, Wei-Te Lei, Hung-Yang Chang, Ming-Dar Lee, Jui-Ming Liu, Ren-Jun Hsu, Nan-Chang Chiu, Hsin Chi, Chun-Chih Peng, Te-Lung Tsai, Chien-Yu Lin

Journal: Medicine (Baltimore). 2017 Sep;96(36):e7992.

 

Scrub typhus is a zoonotic disease that remains an important health threat in endemic areas. Appropriate anti-rickettsial treatment ensures a successful recovery. Doxycycline is a recommended drug, but it is contraindicated in pregnant women and young children. Azithromycin is a safer ...

Last Updated: 8 Sep 2017

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Successful Treatment of Scrub Typhus-Associated Hemophagocytic Lymphohistiocytosis With Chloramphenicol: Report of 3 Pediatric Cases and Literature Review.
 

Author(s): Yong-Hai Zhou, Fang-Qing Xia, Sven Van Poucke, Ming-Hua Zheng

Journal: Medicine (Baltimore). 2016 Feb;95(8):e2928.

 

Scrub typhus is caused by Orientia tsutsugamushi. Any delay in diagnosis can result in delayed treatment and severe complications, including secondary hemophagocytic lymphohistiocytosis, which is rare but potentially fatal.In this paper, the authors present 3 cases of secondary hemophagocytic ...

Last Updated: 4 Mar 2016

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A Spatiotemporal Database to Track Human Scrub Typhus Using the VectorMap Application.
 

Author(s): Daryl J Kelly, Desmond H Foley, Allen L Richards

Journal:

 

Scrub typhus is a potentially fatal mite-borne febrile illness, primarily of the Asia-Pacific Rim. With an endemic area greater than 13 million km2 and millions of people at risk, scrub typhus remains an underreported, often misdiagnosed febrile illness. A comprehensive, updatable ...

Last Updated: 18 Dec 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Scrub Typhus Antibiotic Resistance Trial
 

Status: Not yet recruiting

Condition Summary: Scrub Typhus

 

Last Updated: 8 May 2017

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Scrub Typhus Pediatric Immunology Study
 

Status: Recruiting

Condition Summary: Scrub Typhus

 

Last Updated: 31 Aug 2016

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Scrub Typhus RDT Study
 

Status: Not yet recruiting

Condition Summary: The Prevalence of Scrub Typhus

 

Last Updated: 29 Aug 2017

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