Ulcerative colitis

Common Name(s)

Ulcerative colitis

Ulcerative colitis (UC) is a type of inflammatory bowel disease that affects the large intestine (colon) and rectum. The inner lining of the rectum and colon become red and swollen (inflamed). The condition also causes small sores (ulcers) to form inside the colon and rectum. UC is a long lasting condition, but affected individuals usually have periods with symptoms (flare ups) and periods without symptoms (remission). Symptoms include stomach pains, cramping, rectal bleeds, diarrhea or pain when passing stool. The cause of this condition is unknown, but some experts believe it is caused by an overreaction by the body’s immune system (autoimmune condition). Genetic and environmental factors are also involved. UC typically affects individuals between 15 and 30 years of age and, in the United States, 20% of UC cases occur under the age of 20 years.

Your doctor may suspect UC after ruling out other causes for your symptoms. To confirm the diagnosis, they may order blood tests to look for low blood count (anemia), x-rays and CT scans to image your colon, examine the inside of your colon using a camera (colonoscopy) or examine a stool sample. Although there is no cure, there are various treatment options to help manage the symptoms of this condition. Medications may be prescribed to reduce the inflammation or decrease the response from your immune system. Nutritional supplements may also help. If severe enough, surgery may be needed to remove part of your colon. If you have been diagnosed with UC, talk with your doctor to decide which treatment option is best for you. Support groups are also good resources for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ulcerative colitis" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

Last Updated: 8 Apr 2014

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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

Last Updated: 29 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ulcerative colitis" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

http://www.ccfa.org

Last Updated: 8 Apr 2014

View Details
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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

http://ddnc.org/

Last Updated: 29 Apr 2014

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ulcerative colitis" returned 2778 free, full-text research articles on human participants. First 3 results:

Ulcerative colitis in an adult patient mimicking Henoch-Schönlein purpura: A case report.
 

Author(s): Bin Lu, Li-Li Niu, Xi-Guang Xu, Shu-Lan Yao, Xing-You Tan

Journal: Medicine (Baltimore). 2018 Aug;97(35):e12036.

 

Ulcerative colitis (UC) is one of the chronic inflammatory diseases of the intestinal tract. UC being misdiagnosed as Henoch-Schönlein purpura (HSP) in the elderly has seldom been reported about.

Last Updated: 31 Dec 1969

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Effectiveness and safety of adalimumab to treat outpatient ulcerative colitis: A real-life multicenter, observational study in primary inflammatory bowel disease centers.
 

Author(s): Antonio Tursi, Walter Elisei, Roberto Faggiani, Leonardo Allegretta, Nicola Della Valle, Giacomo Forti, Marilisa Franceschi, Antonio Ferronato, Sara Gallina, Tiziana Larussa, Francesco Luzza, Roberto Lorenzetti, Giammarco Mocci, Antonio Penna, Stefano Rodino', Ladislava Sebkova, Antonio de Medici, Giuseppe Pranzo, Cristina Ricciardelli, Giuseppina Grasso, Stefano Scorza, Costantino Zampaletta, Marcello Picchio

Journal: Medicine (Baltimore). 2018 Aug;97(34):e11897.

 

Adalimumab (ADA) was approved in Italy for the treatment of ulcerative colitis (UC) unresponsive to standard treatments in 2014, but no data from real life are currently available. The aim of the present study was to assess the real-life efficacy and safety of ADA in managing UC outpatients ...

Last Updated: 31 Dec 1969

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Pyoderma Gangrenosum in Ulcerative Colitis.
 

Author(s): Giovanni Perricone, Marcello Vangeli

Journal: N. Engl. J. Med.. 2018 Jul;379(4):e7.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ulcerative colitis" returned 294 free, full-text review articles on human participants. First 3 results:

Pooled analysis of the comparative efficacy between tacrolimus and infliximab for ulcerative colitis.
 

Author(s): Yi-Juan Liu, Hua Fan, Wei-Wei Zhen, Xing Yu, Jin-Tong Chen, Cheng-Dang Wang

Journal: Medicine (Baltimore). 2018 Aug;97(32):e11440.

 

Acute moderate-to-severe steroid-refractory ulcerative colitis (UC) has a poor prognosis and requires optimal rescue therapy. A pooled analysis was conducted to assess tacrolimus and infliximab (IFX) as rescue agents in patients with moderate-to-severe and steroid-refractory UC.

Last Updated: 31 Dec 1969

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Efficacy and safety of Kangfuxin liquid combined with aminosalicylic acid for the treatment of ulcerative colitis: A systematic review and meta-analysis.
 

Author(s): Hui-Biao Li, Mu-Yuan Chen, Zhen-Wen Qiu, Qing-Qun Cai, De-Tang Li, Hong-Mei Tang, Xin-Lin Chen

Journal: Medicine (Baltimore). 2018 May;97(21):e10807.

 

To systematically evaluate the clinical efficacy and safety of Kangfuxin liquid (KFXL) combined with aminosalicylic acid (ASA) in treating ulcerative colitis (UC).

Last Updated: 31 Dec 1969

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[Prognostic factors of ulcerative colitis at the moment of diagnosis].
 

Author(s): Gonzalo Pizarro, Rodrigo Quera, Carolina Figueroa

Journal: Rev Med Chil. 2017 Oct;145(10):1319-1329.

 

The clinical presentation of ulcerative colitis at the moment of diagnosis is variable, and its clinical course is difficult to predict. It can range from a quiescent to a refractory chronic course that may require hospitalization and surgical procedures. It can also have complications ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Faecal Bacteriotherapy for Ulcerative Colitis
 

Status: Recruiting

Condition Summary: Ulcerative Colitis

 

Last Updated: 13 Mar 2018

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Multi-center Acute Severe Ulcerative Colitis Cohort Study (MASCC)
 

Status: Not yet recruiting

Condition Summary: Ulcerative Colitis

 

Last Updated: 11 Sep 2018

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