Uterine sarcoma

Common Name(s)

Uterine sarcoma

Uterine sarcoma is a type of cancer that affects the uterine muscle and the surrounding tissue. The uterus is a female organ in the lower abdomen where the development of a fetus occurs. The lower end of the uterus, called the cervix, leads to the vagina. The upper end is known as the body or corpus of the uterus and is made of three layers. Cancers form when a mutation in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow. This process is known as metastasis. Factors that increase the risk for uterine sarcoma are exposure to pelvic radiation, being of African American race, and having an abnormal copy of the Rb gene.

Endometrial stromal sarcomas are a type of uterine sarcoma that start in the connective tissue of the endometrium, the inner layer of the body of the uterus. These cancers grow slowly. Undifferentiated sarcomas are another type that are fast growing and more aggressive. Uterine leiomyosarcomas are another type that begin in the muscle layer of the body of the uterus known as the myometrium. Symptoms of uterine sarcoma are vaginal bleeding or spotting, pelvic pain, a feeling of pelvic heaviness, and abnormal vaginal discharge. However, these may also be symptoms of other, non-cancerous conditions.

Diagnosis of uterine sarcoma is made through a combination of a pelvic exam, taking a biopsy or tissue sample, and imaging techniques such as an ultrasound, PET, and MRI. Treatment for uterine sarcoma can include surgery, chemotherapy, radiation therapy, and hormone therapy. If you have been diagnosed with uterine sarcoma, talk to your doctor or a gynecologic oncologist about the most current treatment options. Support groups are available for more information and to connect you to other women with uterine sarcoma.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Uterine sarcoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Uterine sarcoma" returned 62 free, full-text research articles on human participants. First 3 results:

Expression and prognostic value of lactate dehydrogenase-A and -D subunits in human uterine myoma and uterine sarcoma.
 

Author(s): Ke-Juan Song, Xiao-Ni Yu, Teng Lv, Yu-Long Chen, Yu-Chao Diao, Su-Li Liu, Yan-Kui Wang, Qin Yao

Journal: Medicine (Baltimore). 2018 Apr;97(14):e0268.

 

This study aimed to determine the expression of lactate dehydrogenase (LDH)-A and LDH-D in patients with uterine myoma, cellular leiomyoma (CLM), and uterine sarcoma and to evaluate their prognostic significance.

Last Updated: 31 Dec 1969

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Clinical Characteristics Differentiating Uterine Sarcoma and Fibroids.
 

Author(s): Innie Chen, Bianca Firth, Laura Hopkins, Olga Bougie, Ri-Hua Xie, Sukhbir Singh

Journal: JSLS. ;22(1):.

 

Uterine fibroids are a common indication for laparoscopy. Unsuspected sarcoma can pose a serious risk if morcellation is used in the procedure. We sought to determine the clinical factors associated with uterine sarcoma compared with uterine fibroids.

Last Updated: 31 Dec 1969

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RNA-sequencing identifies novel GREB1-NCOA2 fusion gene in a uterine sarcoma with the chromosomal translocation t(2;8)(p25;q13).
 

Author(s): Marta Brunetti, Ioannis Panagopoulos, Ludmila Gorunova, Ben Davidson, Sverre Heim, Francesca Micci

Journal: Genes Chromosomes Cancer. 2018 04;57(4):176-181.

 

Sarcomas account for 3% of all uterine malignancies and many of them are characterized by acquired, specific fusion genes whose detection has increased pathogenetic knowledge and diagnostic precision. We describe a novel fusion gene, GREB1-NCOA2, detected by transcriptome sequencing ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Uterine sarcoma" returned 13 free, full-text review articles on human participants. First 3 results:

Molecular biomarkers for uterine leiomyosarcoma and endometrial stromal sarcoma.
 

Author(s): Hideaki Tsuyoshi, Yoshio Yoshida

Journal: Cancer Sci.. 2018 Jun;109(6):1743-1752.

 

Uterine leiomyosarcoma (u-LMS) and endometrial stromal sarcoma (ESS) are among the most frequent soft tissue sarcomas, which, in adults, lead to fatal lung metastases and patients have an extremely poor prognosis. Due to their rarity and heterogeneity, there are no suitable biomarkers ...

Last Updated: 31 Dec 1969

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Endometrial stromal sarcoma: An aggressive uterine malignancy.
 

Author(s): Chaitra P Adiga, Manju Gyanchandani, Lakshmikantha N Goolahally, Rishikesh M Itagi, Kiran V Kalenahalli

Journal:

 

Endometrial stromal sarcoma (ESS) is an aggressive uterine sarcoma. We report a case of a large endometrial stromal sarcoma in a 42 year nulliparous woman with chronic kidney disease presenting with acute urinary retention and irregular per vaginal bleeding. Ultrasound and Doppler ...

Last Updated: 31 Dec 1969

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Uterine sarcoma part III-Targeted therapy: The Taiwan Association of Gynecology (TAG) systematic review.
 

Author(s): Ming-Shyen Yen, Jen-Ruei Chen, Peng-Hui Wang, Kuo-Chang Wen, Yi-Jen Chen, Heung-Tat Ng,

Journal: Taiwan J Obstet Gynecol. 2016 Oct;55(5):625-634.

 

Uterine sarcoma is a very aggressive and highly lethal disease. Even after a comprehensive staging surgery or en block cytoreduction surgery followed by multimodality therapy (often chemotherapy and/or radiation therapy), many patients relapse or present with distant metastases, and ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

IRCI Gynae Sarcomas, High Grade Uterine Sarcoma
 

Status: Recruiting

Condition Summary: Uterine Sarcoma

 

Last Updated: 11 Oct 2016

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Vorinostat (SAHA) in Uterine Sarcoma
 

Status: Recruiting

Condition Summary: Leiomyosarcoma; Endometrial Stromal Tumors; Carcinosarcomas Uterine

 

Last Updated: 16 Apr 2018

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Last Updated: 2 Apr 2018

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