Vernal keratoconjunctivitis

Common Name(s)

Vernal keratoconjunctivitis

Vernal keratoconjunctivitis (VKC) is a chronic, severe allergy that affects the surfaces of the eyes. It most commonly occurs in boys living in warm, dry climates. Attacks associated with VKC are common in the spring (hence the name "vernal") and summer but often reoccur in the winter. Signs and symptoms usually begin before 10 years of age and may include hard, cobblestone-like bumps (papillae) on the upper eyelid; sensitivity to light; redness; sticky mucus discharge; and involuntary blinking or spasms of the eyelid (blepharospasm).  The condition usually subsides at the onset of puberty. It is caused by a hypersensitivity (allergic reaction) to airborne-allergens. Management focuses on preventing "flare ups" and relieving the symptoms of the condition.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Vernal keratoconjunctivitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Vernal keratoconjunctivitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Vernal keratoconjunctivitis" returned 69 free, full-text research articles on human participants. First 3 results:

Systematic approach to managing vernal keratoconjunctivitis in clinical practice: Severity grading system and a treatment algorithm.
 

Author(s): Nikhil S Gokhale

Journal: Indian J Ophthalmol. 2016 Feb;64(2):145-8.

 

Vernal keratoconjunctivitis is an ocular allergy that is common in the pediatric age group. It is often chronic, severe, and nonresponsive to the available treatment options. Management of these children is difficult and often a dilemma for the practitioner. There is a need to simplify ...

Last Updated: 7 Apr 2016

Go To URL
Quiescent and Active Tear Protein Profiles to Predict Vernal Keratoconjunctivitis Reactivation.
 

Author(s): Alessandra Micera, Antonio Di Zazzo, Graziana Esposito, Roberto Sgrulletta, Virginia L Calder, Stefano Bonini

Journal: Biomed Res Int. 2016 ;2016():9672082.

 

Vernal keratoconjunctivitis (VKC) is a chronic recurrent bilateral inflammation of the conjunctiva associated with atopy. Several inflammatory and tissue remodeling factors contribute to VKC disease. The aim is to provide a chip-based protein analysis in tears from patients suffering ...

Last Updated: 18 Mar 2016

Go To URL
Tacrolimus Ointment for Treatment of Vernal Keratoconjunctivitis.
 

Author(s): Abdulrahman M Al-Amri, Aleem Gulzar Mirza, Ahmed Mossa Al-Hakami

Journal: Middle East Afr J Ophthalmol. ;23(1):135-8.

 

To evaluate the safety and efficacy of tacrolimus 0.1% ointment for the treatment of refractory vernal keratoconjunctivitis (VKC).

Last Updated: 9 Mar 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Vernal keratoconjunctivitis" returned 2 free, full-text review articles on human participants. First 3 results:

Vernal keratoconjunctivitis: a major review.
 

Author(s): Sunil Kumar

Journal: Acta Ophthalmol. 2009 Mar;87(2):133-47.

 

Vernal keratoconjunctivitis (VKC) is a chronic, bilateral, at times asymmetrical, seasonally exacerbated, allergic inflammation of the ocular surface, involving tarsal and/or bulbar conjunctiva. Though the allergic nature of this entity has been accepted for a long time, the accumulation ...

Last Updated: 18 Mar 2009

Go To URL
Systematic review and meta-analysis of randomised clinical trials on topical treatments for vernal keratoconjunctivitis.
 

Author(s): F Mantelli, M S Santos, T Petitti, R Sgrulletta, M Cortes, A Lambiase, S Bonini

Journal: Br J Ophthalmol. 2007 Dec;91(12):1656-61.

 

The aim of this study was to assess the efficacy of currently available topical drugs for vernal keratoconjunctivitis (VKC) through a meta-analysis of randomised clinical trials (RCTs).

Last Updated: 20 Nov 2007

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Topical Tacrolimus in Vernal Keratoconjunctivitis
 

Status: Recruiting

Condition Summary: Vernal Keratoconjunctivitis

 

Last Updated: 22 Nov 2015

Go to URL