Von Willebrand disease
is a bleeding disorder that slows the blood clotting process. People with this disoder often experience bruising, nosebleeds, and prolonged bleeding or oozing following an injury, surgery, or having a tooth pulled. In severe cases, heavy bleeding occurs after minor trauma or even in the absence of injury. Milder forms of Von Willebrand disease do not involve spontaneous bleeding, and the condition may become apparent only when abnormal bleeding occurs following surgery or a serious injury. Symptoms may change over time. Increased age, pregnancy, exercise, and stress may make bleeding symptoms become less frequent. This disorder is caused by mutations in the VWF gene and can have different inheritance patterns. Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.