WISKOTT-ALDRICH SYNDROME 2

Common Name(s)

WISKOTT-ALDRICH SYNDROME 2

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "WISKOTT-ALDRICH SYNDROME 2" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "WISKOTT-ALDRICH SYNDROME 2" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "WISKOTT-ALDRICH SYNDROME 2" returned 9 free, full-text research articles on human participants. First 3 results:

IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo.
 

Author(s): Joanna S Kritikou, Carin I M Dahlberg, Marisa A P Baptista, Arnika K Wagner, Pinaki P Banerjee, Lavesh Amar Gwalani, Cecilia Poli, Sudeepta K Panda, Klas Kärre, Susan M Kaech, Fredrik Wermeling, John Andersson, Jordan S Orange, Hanna Brauner, Lisa S Westerberg

Journal:

 

To kill target cells, natural killer (NK) cells organize signaling from activating and inhibitory receptors to form a lytic synapse. Wiskott-Aldrich syndrome (WAS) patients have loss-of-function mutations in the actin regulator WASp and suffer from immunodeficiency with increased ...

Last Updated: 31 Dec 1969

Go To URL
WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site.
 

Author(s): Maor H Pauker, Barak Reicher, Noah Joseph, Inbal Wortzel, Shlomi Jakubowicz, Elad Noy, Orly Perl, Mira Barda-Saad

Journal: J. Biol. Chem.. 2014 Dec;289(50):34503-19.

 

T cell antigen receptor (TCR) engagement has been shown to activate pathways leading to actin cytoskeletal polymerization and reorganization, which are essential for lymphocyte activation and function. Several actin regulatory proteins were implicated in regulating the actin machinery, ...

Last Updated: 31 Dec 1969

Go To URL
A familial case of Wiskott-Aldrich Syndrome with a hotspot mutation in exon 2 of the WAS Gene.
 

Author(s): Sook Kyung Park, Chun Soo Kim, Dae Kyu Song, Joo Young Kim, In Jang Choi, Dae Kwang Kim

Journal: J. Korean Med. Sci.. 2007 Dec;22(6):998-1001.

 

The Wiskott-Aldrich syndrome (WAS) is a severe X-linked disorder characterized classically by thrombocytopenia, immunodeficiency, and eczema. The phenotype observed in this syndrome is caused by mutation in the WAS gene. Peripheral blood DNAs were isolated from an 18-month-old boy ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "WISKOTT-ALDRICH SYNDROME 2" returned 0 free, full-text review articles on human participants.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Participation in a Research Registry for Immune Disorders
 

Status: Recruiting

Condition Summary: Primary Immunodeficiencies; GATA2; CGD (Chronic Granulomatous Disease); Wiskott- Aldrich Syndrome; ADA-SCID/SCID All Forms

 

Last Updated: 13 Oct 2018

Go to URL