Wagner syndrome

Common Name(s)

Wagner syndrome

Wagner syndrome is a hereditary eye disease characterized by a central vitreous cavity which appears empty on slit-lamp examination. The condition was named after the Swiss ophthalmologist Hans Wagner, who described a family with this condition in 1938. Since then less than 50 families have been described. The first signs usually emerge during early adolescence, but onset may be as early as age 2. Wagner syndrome is caused by mutations in the VCAN gene.  It is inherited in an autosomal dominant manner.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Wagner syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Wagner syndrome" returned 11 free, full-text research articles on human participants. First 3 results:

Multimodal Imaging in Wagner Syndrome.
 

Author(s): Akshay S Thomas, Kari Branham, Russell N Van Gelder, Stephen P Daiger, Lori S Sullivan, Sara J Bowne, John R Heckenlively, Mark E Pennesi

Journal: Ophthalmic Surg Lasers Imaging Retina. 2016 Jun;47(6):574-9.

 

Wagner syndrome is a rare vitreoretinopathy described in a limited number of families. Here the authors describe four cases of suspected Wagner syndrome. All four cases had depressed rod and cone function on electroretinography, outer retinal disruption on spectral-domain optical ...

Last Updated: 22 Jun 2016

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A family with Wagner syndrome with uveitis and a new versican mutation.
 

Author(s): Pierre-Raphaël Rothschild, Antoine P Brézin, Brigitte Nedelec, Cyril Burin des Roziers, Tiffany Ghiotti, Lucie Orhant, Mathieu Boimard, Sophie Valleix

Journal:

 

To report the clinical and molecular findings of a kindred with Wagner syndrome (WS) revealed by intraocular inflammatory features.

Last Updated: 31 Oct 2013

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Mutation in collagen II alpha 1 isoforms delineates Stickler and Wagner syndrome phenotypes.
 

Author(s): Khanh-Nhat Tran-Viet, Vincent Soler, Valencia Quiette, Caldwell Powell, Tammy Yanovitch, Ravikanth Metlapally, Xiaoyan Luo, Nicholas Katsanis, Erica Nading, Terri L Young

Journal:

 

Stickler syndrome is an arthro-ophthalmopathy with phenotypic overlap with Wagner syndrome. The common Stickler syndrome type I is inherited as an autosomal dominant trait, with causal mutations in collagen type II alpha 1 (COL2A1). Wagner syndrome is associated with mutations in ...

Last Updated: 17 Apr 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Wagner syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

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