Werner syndrome

Common Name(s)

Werner syndrome, Werner's syndrome

Werner syndrome is a rare genetic condition that causes accelerated aging. Affected individuals usually display normal growth and development during childhood but then lack a normal growth spurt at puberty. As a result, they are typically short in height. Those with the condition also typically have unique facial features that include a beaked nose and prominent eyes.

Individuals with Werner syndrome usually notice the first signs of rapid aging during their twenties. These first symptoms may include graying or loss of hair, a hoarse voice, and the development of thinner, rougher skin. In the individual’s thirties, more advanced signs of aging will likely begin. These include cloudy eye lenses (cataracts), sores or open wounds on the skin (ulcers), type II diabetes, thinning of bones (osteoporosis), various types of cancer, and a decrease or loss of fertility and other genital functioning (hypogonadism). Most affected individuals pass away in their late forties to early fifties from conditions such as cancer and atherosclerosis (hardening of the arteries).

There is a specific gene, called "WRN," that is associated with this condition. A functional WRN gene instructs the body to produce a protein that is responsible for protecting a person’s DNA from damage and keeping the DNA in its proper shape. If the WRN gene is changed (mutated), the individual’s DNA becomes more prone to damage and leads to the various physical signs of Werner syndrome. This condition is inherited in an autosomal recessive pattern, which means a person must have a mutation in both copies of their WRN gene in order to develop the condition. Contacting a genetic counselor or specialist may be helpful to further explain the genetics and inheritance pattern of this condition.

Unfortunately there is no cure for Werner syndrome at this time. If you or a loved one has been diagnosed with Werner syndrome, contact your doctor to discuss current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Werner syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Werner syndrome" returned 193 free, full-text research articles on human participants. First 3 results:

A case report on Herlyn-Werner-Wunderlich syndrome with spontaneous abortion.
 

Author(s): Guifeng Jia, Wei Chai, Miao Cui, Yan Wen, Lifeng Cui, Fengyan Gong

Journal: Medicine (Baltimore). 2018 Sep;97(36):e12004.

 

Herlyn-Werner-Wunderlich syndrome (HWWS) is a rare congenital abnormality of the urogenital tract characterized by uterus didelphys, obstructed hemivagina, and ipsilateral renal agenesis. It is usually diagnosed after menarche, with a clinical presentation of dysmenorrhea, recurrent ...

Last Updated: 31 Dec 1969

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Management of cataract in Werner syndrome.
 

Author(s): Rakhi Kusumesh, Bibhuti Prassan Sinha, Anita Ambastha, Santosh Kumar Thakur

Journal: Indian J Ophthalmol. 2018 09;66(9):1337-1339.

 

Werner syndrome (WS) is a rare progressive disorder. It is characterized by the appearance of unusually accelerated aging (progeria) including bilateral senile cataract. Here, we report a successful management of hypermature cataract in WS.

Last Updated: 31 Dec 1969

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Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome.
 

Author(s): T Guastafierro, M G Bacalini, A Marcoccia, D Gentilini, S Pisoni, A M Di Blasio, A Corsi, C Franceschi, D Raimondo, A Spanò, P Garagnani, F Bondanini

Journal:

 

Werner syndrome is a progeroid disorder characterized by premature age-related phenotypes. Although it is well established that autosomal recessive mutations in the WRN gene is responsible for Werner syndrome, the molecular alterations that lead to disease phenotype remain still unidentified.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Werner syndrome" returned 11 free, full-text review articles on human participants. First 3 results:

Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions.
 

Author(s): Junko Oshima, Julia M Sidorova, Raymond J Monnat

Journal: Ageing Res. Rev.. 2017 Jan;33():105-114.

 

Werner syndrome (WS) is a prototypical segmental progeroid syndrome characterized by multiple features consistent with accelerated aging. It is caused by null mutations of the WRN gene, which encodes a member of the RECQ family of DNA helicases. A unique feature of the WRN helicase ...

Last Updated: 31 Dec 1969

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Scoliosis in Herlyn-Werner-Wunderlich syndrome: a case report and literature review.
 

Author(s): Zheng Li, Xin Yu, Jianxiong Shen, Jinqian Liang

Journal: Medicine (Baltimore). 2014 Dec;93(28):e185.

 

Herlyn-Werner-Wunderlich syndrome (HWWS) is a congenital Müllerian duct anomaly characterized by uterine didelphys, obstructed hemivagina, and ipsilateral renal agenesis. Little is reported about spinal deformity associated with this syndrome. This study presents a case of scoliosis ...

Last Updated: 31 Dec 1969

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Search and insights into novel genetic alterations leading to classical and atypical Werner syndrome.
 

Author(s): Junko Oshima, Fuki M Hisama

Journal: Gerontology. 2014 ;60(3):239-46.

 

Segmental progeroid syndromes are a group of disorders with multiple features resembling accelerated aging. Adult-onset Werner syndrome (WS) and childhood-onset Hutchinson-Gilford progeria syndrome are the best known examples. The discovery of genes responsible for such syndromes ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.