Wernicke's encephalopathy

Common Name(s)

Wernicke's encephalopathy

Wernicke’s encephalopathy refers to the presence of neurological symptoms (affecting the brain, spinal cord, or nerves) brought on by a thiamine deficiency. A thiamine (vitamin B1) deficiency is often associated with alcoholism but can also be due to bariatric surgery (operations performed to reduce the size of the stomach so an individual can lose weight), prolonged starvation, or HIV/AIDS.

Symptoms of this condition may include uncontrolled or unintentional muscle movements, confusion, and eye abnormalities. Chronic thiamine deficiency could lead to Korsakoff syndrome (please also see Wernicke-Korsakoff syndrome). Taking thiamine supplements can improve the patient’s condition when treated early, but late-stage Wernicke encephalopathy can be significantly disabling. Patients who have been treated for Wernicke's encephalopathy should avoid alcohol consumption and other behaviors that may make them more susceptible to thiamine deficiency. Talk with your doctor if you or a family member has been diagnosed with Wernicke’s encephalopathy to discuss treatment and care plan options. Support groups are also a good source of support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Wernicke's encephalopathy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Wernicke's encephalopathy" returned 86 free, full-text research articles on human participants. First 3 results:

Are Psychiatric Inpatients at Risk of Developing Wernicke's Encephalopathy Being Identified and Adequately Treated?
 

Author(s): Medhat Guirguis, Stephen Manning, Marina Chavez, Jessica Nelson, Regina Baronia, Sailatha Bobba, Jafreen Ahmed, Ijeoma Ajufo

Journal:

 

Wernicke's encephalopathy is caused by thiamine deficiency and occurs predominantly in alcohol-dependent individuals but also develops in those who are malnourished due to other reasons including medical and psychiatric disorders. This study examined the frequency rate and management ...

Last Updated: 31 Dec 1969

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Nystagmus from Wernicke's Encephalopathy.
 

Author(s): Pria Anand, Daniel R Gold

Journal: N. Engl. J. Med.. 2017 Jul;377(4):e5.

 

Last Updated: 31 Dec 1969

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Wernicke's Encephalopathy Presenting with Bilateral Complete Horizontal and Downward Gaze Palsy in a Malnourished Patient.
 

Author(s): Won Jae Kim, Myung Mi Kim

Journal: Korean J Ophthalmol. 2017 08;31(4):372-374.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Wernicke's encephalopathy" returned 7 free, full-text review articles on human participants. First 3 results:

High-dose Parenteral Thiamine in Treatment of Wernicke's Encephalopathy: Case Series and Review of the Literature.
 

Author(s): Andrew Nishimoto, Justin Usery, John C Winton, Jennifer Twilla

Journal: In Vivo. 2017 01;31(1):121-124.

 

Thiamine deficiency can lead to Wernicke's encephalopathy (WE), an acute and potentially life-threatening neurological disorder. Even though the main treatment modality for WE consists of thiamine replacement, evidence supporting an optimal dosing strategy and duration is unclear.

Last Updated: 31 Dec 1969

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Palliative treatment of thiamine-related encephalopathy (Wernicke's encephalopathy) in cancer: A case series and review of the literature.
 

Author(s): Elie Isenberg-Grzeda, Alan John Hsu, Vaios Hatzoglou, Christian Nelso, William Breitbart

Journal: Palliat Support Care. 2015 Oct;13(5):1241-9.

 

Thiamine-related encephalopathy (Wernicke's encephalopathy) is a neuropsychiatric syndrome caused by a vitamin B1 (thiamine) deficiency often associated with alcoholism. Cancer predisposes patients to thiamine deficiency unrelated to alcoholism, though many cases are missed clinically. ...

Last Updated: 31 Dec 1969

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MR imaging findings in alcoholic and nonalcoholic acute Wernicke's encephalopathy: a review.
 

Author(s): Gaetana Manzo, Angela De Gennaro, Attilio Cozzolino, Antonietta Serino, Giacomo Fenza, Andrea Manto

Journal: Biomed Res Int. 2014 ;2014():503596.

 

Wernicke's encephalopathy (WE) is a severe neurological syndrome caused by thiamine (vitamin B1) deficiency and clinically characterized by the sudden onset of mental status changes, ocular abnormalities, and ataxia. Apart from chronic alcoholism, the most common cause of WE, a lot ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Optimum Thiamine Intervention (OpTIn) Trial
 

Status: Recruiting

Condition Summary: Wernicke-Korsakoff Syndrome

 

Last Updated: 12 Nov 2017

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Alcohol: Thiamine and or Magnesium 1
 

Status: Recruiting

Condition Summary: Alcohol Withdrawal; Lactic Acidosis; Vitamin B1 Deficiency; Magnesium Deficiency; Wernicke Encephalopathy

 

Last Updated: 15 Mar 2018

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Modeling Treated Recovery From Aphasia
 

Status: Recruiting

Condition Summary: Aphasia; Stroke; Stroke, Ischemic; Aphasia, Broca; Aphasia, Global; Aphasia, Mixed; Aphasia, Jargon; Aphasia, Expressive; Aphasia, Conduction; Aphasia, Fluent; Aphasia, Anomic

 

Last Updated: 30 Jan 2018

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