Melioidosis

Common Name(s)

Melioidosis, Whitmore's disease

Melioidosis is an infectious disease caused by a bacteria found in contaminated soil and water. It is a disease that is especially common in Thailand and northern Australia, but also problematic in tropical areas such as the South Pacific, Africa or India. The bacteria linked with melioidosis is found in soil, rice paddies, or still waters in these areas. A person may become infected by inhaling contaminated dust or water particles, by drinking contaminated water, or by having contaminated soil or water enter the body through an open wound or scratch. Person-to-person spread of the disease is rare.

Common symptoms of melioidosis may include shortness of breath, cough, and fever. Additionally, the condition may cause a variety of breathing illnesses from mild bronchitis, or more seriously, pneumonia. A skin infection may develop if an opening in the skin is contaminated. This area can then swell and form an ulcer (sore) or an abscess (pus buildup under the skin). In more severe cases of melioidosis, symptoms may also include weight loss, disorientation, or seizures. Melioidosis symptoms are usually noticed within two to four weeks after infection, but can show up as early as the day after to as late as many years after. Diagnosis is usually made by examining blood and urine samples.

Individuals with other preexisting conditions that weaken the immune system, such as diabetes or AIDS, are more likely to get infected. These individuals should avoid soil and water in tropical farm areas that may have been contaminated with the bacteria. If left untreated, melioidosis can be fatal. However, this disease is treatable with medication. Therefore, if you believe you have melioidosis, contact your doctor so you may begin treatment as soon as possible.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Melioidosis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Melioidosis" returned 338 free, full-text research articles on human participants. First 3 results:

Factors affecting clinical outcomes in the management of melioidosis in Singapore: a 16-year case series.
 

Author(s): Jaime Mei-Fong Chien, Seyed Ehsan Saffari, Ai-Ling Tan, Thuan-Tong Tan

Journal:

 

Burkholderia pseudomallei is a gram negative bacteria that causes a spectrum of human diseases in the tropics. Although melioidosis is endemic in Southeast Asia, large clinical case series were rarely reported from metropolitan Singapore.

Last Updated: 31 Dec 1969

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Relapse of chronic melioidosis in a paediatric cystic fibrosis patient: first case report from Malaysia.
 

Author(s): Vanitha Mariappan, Surendran Thavagnanam, Kumutha Malar Vellasamy, Cindy Ju Shuan Teh, Nadia Atiya, Sasheela Ponnampalavanar, Jamuna Vadivelu

Journal:

 

Burkholderia pseudomallei is the causative agent of melioidosis, which is a potentially life threatening disease endemic in Southeast Asian countries. In Malaysia, cystic fibrosis (CF) is an uncommon condition. The association between CF and B.pseudomallei infections has been reported ...

Last Updated: 31 Dec 1969

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First co-infection case of melioidosis and Japanese encephalitis in China.
 

Author(s): X Y Li, B X Ke, C N Chen, H L Xiao, M Z Liu, Y C Xiong, R Bai, J D Chen, C W Ke

Journal:

 

Melioidosis is endemic in Southeast Asia and northern Australia. Infection usually follows percutaneous inoculation or inhalation or ingestion of the causative bacterium, Burkholderia pseudomallei, which is present in soil and surface water in endemic regions. Japanese encephalitis ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Melioidosis" returned 29 free, full-text review articles on human participants. First 3 results:

Emergence of melioidosis in the Indian Ocean region: Two new cases and a literature review.
 

Author(s): Nicolas Allou, Olivier Martinet, Jérôme Allyn, Bruno Bouchet, Marie-Christine Jaffar-Bandjee, Thomas Galas, Nicolas Traversier, Olivier Belmonte

Journal:

 

Melioidosis is a disease caused by bacteria called B. pseudomallei. Infections can develop after contact with standing water. This disease can reach all the organs and especially the lungs. It is associated with a high mortality rate (up to 50%). Melioidosis is endemic in northern ...

Last Updated: 31 Dec 1969

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Type III Secretion in the Melioidosis Pathogen .
 

Author(s): Charles W Vander Broek, Joanne M Stevens

Journal:

 

is a Gram-negative intracellular pathogen and the causative agent of melioidosis, a severe disease of both humans and animals. Melioidosis is an emerging disease which is predicted to be vastly under-reported. Type III Secretion Systems (T3SSs) are critical virulence factors in Gram ...

Last Updated: 31 Dec 1969

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Melioidosis: Clinical impact and public health threat in the tropics.
 

Author(s): Ramar Perumal Samy, Bradley G Stiles, Gautam Sethi, Lina H K Lim

Journal:

 

This review briefly summarizes the geographical distribution and clinical impact of melioidosis, especially in the tropics. Burkholderia pseudomallei (a gram-negative bacterium) is the major causative agent for melioidosis, which is prevalent in Singapore, Malaysia, Thailand, Vietnam, ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Clinical Presentation of Melioidosis in Head and Neck Region
 

Status: Recruiting

Condition Summary: Melioidosis; Head and Neck Infection

 

Last Updated: 8 Feb 2017

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Adapting LFI for Melioidosis
 

Status: Recruiting

Condition Summary: Melioidosis

 

Last Updated: 3 Jul 2018

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